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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Parlodel.
SAFE IF PRESCRIBED
Parlodel is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
CONSULT YOUR DOCTOR
Parlodel is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Parlodel is usually not used during breastfeeding because it suppresses lactation.
CAUTION
Parlodel may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Parlodel is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Parlodel may not be needed in these patients. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Parlodel in patients with liver disease. Please consult your doctor.
However, a cautious use of this medicine is advised in these patients.
Medicine Overview of Parlodel 2.5mg Tablet
Introduction
Parlodel is a dopamine agonists and prolactin inhibitors. It is used in the treatment of medical condition occurs as of high level of prolactin such as infertility, or abnormal production of breast milk. Parlodel should be taken with food, but take it at the same time every day for better results. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for...
... Show moreUses of Parlodel
- High levels of prolactin
- Female infertility
- Acromegaly
Side effects of Parlodel
Common
- Nausea
- Vomiting
- Headache
- Dizziness
- Fatigue
How to use Parlodel
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Parlodel is to be taken with food.
How Parlodel works
Parlodel is a dopamine receptor agonist. It decreases the release of prolactin (milk hormone) in the body. Overproduction of this hormone is associated with abnormal production of breast milk as well as suppression of the sexual glands which can cause infertility. Reducing prolactin levels with Parlodel can therefore improve these conditions. In acromegaly, it works by lowering the amount of growth hormone in the body.
Quick Tips
- Parlodel is used to treat conditions caused by excess production of a natural hormone called prolactin such as infertility, or abnormal production of breast milk (galactorrhoea).
- It should be taken with or after food to avoid side effects such as nausea or indigestion.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Use caution while driving or doing anything that requires concentration as Parlodel can cause dizziness and sleepiness.
- Do not take Parlodel if you are breastfeeding.
- Monitoring of blood pressure may be advised regularly during treatment with Parlodel.
Brief Description
Indication
Parkinson's disease, Galactorrhoea, Hypogonadism, Infertility, acromegaly, Lactation suppression, benign breast and menstrual disorders, Amenorrhea, hyperprolactinaemia
.
Administration
Should be taken with food.
Adult Dose
Adult: PO Parkinson's disease As adjunct to levodopa: 1st wk: 1-1.25 mg at night, 2nd wk: 2-2.5 mg at night; 3rd wk: 2.5 mg twice daily; 4th wk: 2.5 mg 3 times/day, then increase as needed. Maintenance: 10-40 mg/day. Hyperprolactinemia Initial: 1.25-2.5 mg PO qDay May increase by 2.5 mg/day q2-7Days Usual therapeutic dosage 5-7.5 mg/day, ranges from 2.5-15 mg/day Up to 30 mg/day has been used in some patients with amenorrhea &/or galactorrhea Acromegaly (Parlodel) 1.25-2.5 mg PO qHS for 3 days May increase by 1.25-2.5 mg/day at q3-7Days Not to exceed 100 mg/day Adjunct to surgery and radiotherapy...
... Show moreChild Dose
Hyperprolactinemia
11-15 years: 1.25-2.5 mg PO qDay (initially)
Maintenance: 2.5-10 mg/day
Contraindication
Breast carcinoma, hypersensitivity to ergot alkaloids, uncontrolled hypertension, severe ischaemic heart disease. Pregnancy and lactation.
Mode of Action
Bromocriptine is a dopamine D2 and D3-agonist which works by activating postsynaptic dopamine receptors in the tuberoinfundibular and nigrostriatal pathways. It also inhibits the secretion of prolactin from the anterior pituitary and is used in the treatment of prolactinoma and in endocrinological disorders.
Precaution
Increased risk of conception, patients with peptic ulcer, diabetes, diabetic retinopathy, impaired hepatic or renal function, pleuropulmonary signs and symptoms, history of psychosis, CV disease, dementia or concurrent antihypertensive therapy, ability to drive vehicles or operating machinery may be impaired.
Lactation: should not be used during lactation
Side Effect
>10%
Nausea (49%),Hypotension (30%),Headache (19%),Dizziness (17%)
1-10%
Abdominal cramps,Anorexia,Constipation,Dyspepsia,Dysphagia,Epigastric pain,GI hemorrhage,Vomiting,Drowsiness,Fatigue,Faintness,Hallucinations Visual,Insomnia,Lightheadedness,Nighmares,Paranoia,Psychosis,Seizure,Vertigo,Arrhythmias,Bradycardia,Hypertension,MI,Mottled skin,Orthostasis,Vasospasm,Palpitations,Pericardial effusions,Raynaud's syndrome exacertabtion,Syncope,Blepharospasm,BUN increased,Burning discomfort of the eye,Diplopia,Facial pallor,Leg cramps,Nasal congestion,Rash,Urticaria
Pregnancy Category Note
Pregnancy Safety of Bromocriptine treatment during pregnancy to the mother and fetus has not been established If pregnancy occurs during Bromocriptine administration, careful observation of these patients is mandatory Prolactin-secreting adenomas may expand and compression of optic/other cranial nerves may occur, emergency pituitary surgery becoming necessary; in most cases, the compression resolves following delivery Reinitiation of Bromocriptine treatment has been reported to produce improvement in the visual fields of patients in whom nerve compression has occurred during pregnancy In patients being treated for hyperprolactinemia, Bromocriptine should be withdrawn when pregnancy is diagnosed Acromegaly, prolactinoma, or Parkinson disease Patients who subsequently...
... Show moreInteraction
Bioavailability increased if given along with erythromycin. Alcohol reduces tolerance to bromocriptine and vice-versa. Effects of antihypertensives may be potentiated. Avoid concurrent psychotropics.
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