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Oral
Constipation
Adult: 15-30 mg (as total sennosides) 1-2 times daily.
Bowel evacuation
Adult: 105-157.5 mg of sennosides on the day before the procedure. May be given as a liquid preparation.
Child Dose
Oral
Constipation
Child: 2-6 yr: 3.75-7.5 mg once daily in the morning;
6-12 yr: 7.5-15 mg once daily at night or in the morning;
>12 yr: 15-30 mg at bedtime.
Contraindication
Nausea or vomiting, undiagnosed abdominal pain, intestinal obstruction.
Mode of Action
Sennosides A and B increase intestinal motility through release of active anthraquinones into the colon by colonic bacteria. Purified sennosides (sennosides A and B) are used similarly to senna.
Precaution
Inflammatory bowel disease. Avoid prolonged use.
Side Effect
Mild abdominal discomfort e.g. colic and cramps; diarrhoea, hypokalaemia and atonic non-functioning colon (prolonged use); reversible melanosis coli (chronic use). May colour the urine yellowish-brown at acidic pH or red at alkaline pH.
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