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Metglip DS 5/500
Pacific Pharmaceuticals Ltd.
Generic: Glipizide + Metformin Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Metglip DS 5/500.
CONSULT YOUR DOCTOR
Metglip DS 5/500 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Metglip DS 5/500 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
CAUTION
Metglip DS 5/500 should be used with caution in patients with kidney disease. Dose adjustment of Metglip DS 5/500 may be needed. Please consult your doctor.
Use of Metglip DS 5/500 is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
CAUTION
Metglip DS 5/500 should be used with caution in patients with liver disease. Dose adjustment of Metglip DS 5/500 may be needed. Please consult your doctor.
Metglip DS 5/500 is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.
Medicine Overview of Metglip DS 5/500 5mg+500mg Tablet
Introduction
Metglip DS 5/500 belongs to a category of medicines known as anti-diabetic drugs. It is a combination of two medicines used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels in people with diabetes. Metglip DS 5/500 should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working according to your blood sugar levels. Keep taking this medicine, even if you feel well...
... Show moreUses of Metglip DS 5/500
- Type 2 diabetes mellitus
Side effects of Metglip DS 5/500
Common
- Hypoglycemia (low blood glucose level)
- Taste change
- Nausea
- Stomach pain
- Diarrhea
- Headache
- Upper respiratory tract infection
How to use Metglip DS 5/500
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Metglip DS 5/500 is to be taken with food.
How Metglip DS 5/500 works
Metglip DS 5/500 is a combination of two antidiabetic medicines: Glipizide and Metformin. Glipizide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin.
Quick Tips
- Monitor your blood sugar level regularly while you are taking this medicine.
- It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
- Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Metglip DS 5/500 may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
- Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Brief Description
Indication
Type 2 DM
Administration
Should be taken with food.
Adult Dose
Type 2 Diabetes Mellitus
Initial treatment: start at 2.5 mg/250 mg (glipizide/metformin) PO qDay with food
If fasting plasma glucose = 280-320 mg/dL: 2.5/500 mg PO q12hr
May adjust daily dose in increments of 1 tab every 2 wk.
Max: Glipizide 10 mg and metformin 2,000 mg daily.
Type 2 DM Inadequately Controlled on Sulfonylurea &/or Metformin
2nd-line treatment: Start at 2.5/500 mg or 5/500 mg PO q12hr with food
May adjust daily dose in increments of not more than 5 mg/500 mg.
Max: Glipizide 20 mg and metformin 2,000 mg daily.
Hepatic impairment: Contraindicated.
Renal Dose
Renal impairment: Serum creatinine (SCr) >1.5 mg/dL (males) or >1.4 mg/dL (females)
Obtain eGFR before starting metformin
eGFR <30 mL/min/1.73 m²: Contraindicated
eGFR 30-45 mL/min/1.73 m²: Not recommended to initiate treatment
Monitor eGFR at least annually or more often for those at risk for renal impairment (eg, elderly)
If eGFR falls below 45mL/min/1.73 m² while taking metformin, risks and benefits of continuing therapy should be evaluated
If eGFR falls below 30 mL/min/1.73 m²: while taking metformin, discontinue the drug
Contraindication
Hypersensitivity. Type 2 diabetes mellitus; ketoacidosis; severe renal or hepatic insufficiency, diabetic coma, cardiac failure, recent MI, CHF. IDDM; severe infection; acute or chronic metabolic acidosis with or without coma; stress, trauma; severe impairment of thyroid function; dehydration, acute or chronic alcoholism. Pregnancy, lactation.
Mode of Action
Glipizide stimulates insulin release from pancreatic beta-cells and reduces gluconeogenesis in liver cells. It also increases insulin sensitivity at target sites. Metformin decreases hepatic gluconeogenesis, decreases intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilisation).
Precaution
Hypoglycaemia, stress, elderly. Thyroid impairment, monitor blood-glucose conc and renal function regularly.
Lactation: enters breast milk; not recommended
Side Effect
Glipizide: GI upsets, diarrhoea, nausea; allergic skin reactions, leucopaenia, thrombocytopaenia, agranulocytosis, hyponatraemia; jaundice; haemolytic anaemia, pancytopaenia.
Metformin: Anorexia, nausea, vomiting, diarrhoea, wt loss, flatulence, occasional metallic taste; weakness; hypoglycaemia; rash, malabsorption of Vitamin
Potentially Fatal: Glipizide: Hypoglycaemia in presence of renal or hepatic damage and alcohol. Metformin: Lactic acidosis in presence of renal failure and alcoholism.
Interaction
Glipizide: Decreased effect with beta-blockers, cholestyramine, hydantoins, thiazide diuretics and urinary alkalinizers.
Metformin: Additive effect with sulphonylureas. Antagonistic effects with diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, Ca channel blockers and isoniazid.
Potentially Fatal: Glipizide: Increased glipizide levels and effects with fluconazole, gemfibrozil, ketoconazole, NSAIDs, pioglitazone and sulfonamides. Increased hypoglycaemic effects with H2 antagonists, anticoagulants, androgens, cimetidine, salicylates, tricyclic antidepressants, probenecid, MAOIs, methyldopa, digitalis glycosides and urinary acidifiers.
Metformin: Lactic acidosis with alcohol and potentiation of hypoglycaemic effect. Cimetidine and furosemide may increase plasma-metformin levels. Drugs eliminated via renal tubular secretion may increase metformin levels.
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