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Mitomycin-C

Tablet
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Rainbow Traders

Generic: Mitomycin

1 Tablet
৳ 0

Medicine Overview of Mitomycin-C Tablet

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Introduction

Mitomycin-C is used in the treatment of certain kinds of cancer of pancreas, breast, lung, and stomach. It can be used alone or in combination with some medicines as part of combination chemotherapy. It works by interfering with the growth of cancer cells, which are eventually destroyed. Mitomycin-C is given as an injection into vein under the supervision of a doctor and should not be self-administered. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include anemia (low number of red blood cells), decreased white blood cell count, increased bleeding tendency, loss of appetite, nausea, and vomiting. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Before taking this medicine, inform your doctor if you have medical conditions involving blood, kidney, and liver or if you are suffering from any breathing disorder. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Mitomycin-C

  • Pancreatic cancer
  • Breast cancer
  • Non-small cell lung cancer
  • Stomach cancer

Side effects of Mitomycin-C

Common
  • Anemia (low number of red blood cells)
  • Decreased white blood cell count
  • Increased bleeding tendency
  • Loss of appetite
  • Nausea
  • Vomiting
  • Feeling of discomfort
  • Low blood platelets
  • Weight loss
  • Rash

How to use Mitomycin-C

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Mitomycin-C works

Mitomycin-C is an anti-cancer medication. It works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.

Quick Tips

  • Inform your doctor if you have any of the following medical conditions: kidney disease; heart disease; or asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder.
  • Before you take mitomycin, inform your doctor if have /are being treated for kidney disease, bleeding disorder or blood disorder.
  • Take precautions as mitomycin can lower the ability of your body to fight infections and the ability of your blood to clot. You may get an infection or bleed more easily.
  • Seek immediate medical attention if you notice any redness, sores, oozing, or other skin changes during or after your treatment with mitomycin. Skin changes can occur several weeks or months after a mitomycin injection.
  • Do not drive or operate machinery as mitomycin may cause weakness and lethargy.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Brief Description

Indication

Solid tumours, non-invasive bladder cancer, stomach cancer, pancreas cancer, metastatic breast cancer, advanced cervical cancer, anal carcinoma

Administration

IV Preparation Reconstitute with SWI to a concentration of 0.5 mg/mL IV Administration Administer slow IV push by central line only Flush with 5-10 mL of IV solution before & after drug administration

Adult Dose

Intravenous Solid tumours The usual dose is in the range of 4-10 mg (0.06-0.15 mg/kg) given at 1-6 weekly intervals depending on whether other drugs are given in combination and on bone marrow recovery. In a number of combination schedules, the dose is 10 mg/m2 of body surface area, the course being repeated at intervals for as long as required. A course ranging from 40-80 mg (0.58-1.2 mg/kg) is often required for a satisfactory response when used alone or in combination. A higher dosage course may be given when used alone or as part of a particular combination schedule and total cumulative doses exceeding 2 mg/kg have been given. Intravesical Superficial bladder tumours In the treatment of superficial bladder tumours the usual dose is 20-40 mg dissolved in 20-40 ml of diluent, instilled into the bladder through a urethral catheter, weekly or three times a week for a total of 20 doses. The dose should be retained by the patient for a minimum of one hour. During this one-hour period the patient should be rotated every 15 minutes to ensure that the Mitomycin-C comes into contact with all areas of the bladder urothelium. When the bladder is emptied in the voiding process, care must be taken to ensure that no contamination occurs locally in the groin and genitalia areas. In the prevention of recurrent superficial bladder tumours, various doses have been used. These include 20 mg in 20 ml of diluent every two weeks and 40 mg in 40 ml of diluent monthly or three monthly. The dose is instilled into the bladder through a urethral catheter. In both cases, the dose should be adjusted in accordance with the age and condition of the patient.

Child Dose

Safety and efficacy not established

Renal Dose

Renal Impairment Serum creatinine >1.7 mg/dL: Avoid use CrCl <10 mL/min: Decrease dose by 25% CAPD: Decrease dose by 25%

Contraindication

Hypersensitivity. Patient w/ platelet counts <100,000/mm3, leukocyte counts <4,000/mm3 or serum creatinine concentration >1.7 mg/dL. Patient w/ substantial prolongation of prothrombin time or bleeding time, coagulation disorders, increased bleeding tendency. Pregnancy and lactation.

Mode of Action

Mitomycin is an antineoplastic antibiotic which is enzymatically reduced to its active metabolite w/in susceptible cells. The active metabolite appears to cause cross-linking of DNA (primarily w/ guanine and cytosine pairs). It is also active against gm+ve bacteria and some viruses.

Precaution

Patient w/ bone marrow depression, infections including varicella infection. Hepatic or renal impairment. Patient Counselling This drug may cause generalised weakness and lethargy, if affected, do not drive or operate machinery. Monitoring Parameters Repeated haematologic studies (platelet count, leukocyte count, differential, prothrombin time, bleeding time and Hb determinations) are necessary during therapy and for at least 7 wk following discontinuance of the drug. Carefully monitor LFTs and renal function test. Lactation: Not known if excreted in breast milk, do not nurse

Side Effect

>10% Hemolytic uremic syndrome (≤15%),Myelosuppression (64%),Nausea/vomiting (14%),Fever (14%) 1-10% Stomatitis (4%),Increased serum creatinine (2%),Mucous membrane toxicity (4%) Frequency Not Defined Fatigue,Pulmonary toxicity,Dyspnea,Cystitis,Interstitial fibrosis,Nephrotoxicity,Amenorrhea,Alopecia Potentially Fatal: Myelosuppression, haemolytic-uraemic syndrome.

Interaction

Increased incidence of cardiotoxicity w/ doxorubicin. Potentially Fatal: Increased risk of intravascular haemolysis and renal failure w/ fluorouracil. Increased risk of haemolytic uraemic syndrome w/ tamoxifen. Acute pulmonary toxicity w/ vinca alkaloids (e.g. vinblastine, vinorelbine). Increased bone marrow depressant effects of aclarubicin.

Buy Mitomycin-C from Arogga

In Bangladesh, you can get the original Mitomycin-C. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Mitomycin-C in Bangladesh?

The latest price of Mitomycin-C in Bangladesh is 0৳. You can buy Mitomycin-C at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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UNSAFE
Mitomycin-C may cause excessive drowsiness with alcohol.
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UNSAFE
Mitomycin-C is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
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CAUTION
Mitomycin-C should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
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UNSAFE
Mitomycin-C may cause side effects which could affect your ability to drive. Mitomycin-C may cause nausea and vomiting and thereby reduce your reaction times to such an extent that the ability to drive a motor vehicle is impaired.
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CAUTION
Mitomycin-C should be used with caution in patients with kidney disease. Dose adjustment of Mitomycin-C may be needed. Please consult your doctor. Use of Mitomycin-C is not recommended in patients with end-stage kidney disease.
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CAUTION
Mitomycin-C should be used with caution in patients with liver disease. Dose adjustment of Mitomycin-C may be needed. Please consult your doctor. Use of Mitomycin-C may not be recommended in some patients with liver disease.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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