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Ameloss 5
Incepta Pharmaceuticals Ltd.
Generic: Donepezil Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Ameloss 5.
CONSULT YOUR DOCTOR
Ameloss 5 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Ameloss 5 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Ameloss 5 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Ameloss 5 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Ameloss 5 may not be needed in these patients. Please consult your doctor.
CAUTION
Ameloss 5 should be used with caution in patients with liver disease. Dose adjustment of Ameloss 5 may be needed. Please consult your doctor.
Medicine Overview of Ameloss 5mg Tablet
Introduction
Ameloss 5 is used to treat mild to moderate dementia in Alzheimer’s disease, a progressive illness which gradually affects memory and thinking. It does not cure this illnesses but may help improve memory, awareness and other symptoms. Your doctor will explain how to take Ameloss 5 and give you the one most suitable for you. Follow the instructions carefully to get the most benefit. The dose may change from time to time to suit your individual needs. You may take it with food, preferably at night before going to bed. It can take up to few weeks for symptoms to...
... Show moreUses of Ameloss 5
- Alzheimer's disease
Side effects of Ameloss 5
Common
- Nausea
- Vomiting
- Diarrhea
How to use Ameloss 5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ameloss 5 may be taken with or without food, but it is better to take it at a fixed time.
How Ameloss 5 works
Memory loss in Alzheimer’s disease occurs due to disturbances of signal transmission in the brain. Ameloss 5 is a cholinesterase inhibitor. It works by increasing the levels of a chemical messenger (acetylcholine) involved in transmmission of nerve signals. This improves memory and thinking.
What if you forget to take Ameloss 5?
If you miss a dose of Ameloss 5, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- You have been prescribed Ameloss 5 to slow down the progression of Alzheimer's disease.
- It does not cure Alzheimer's disease but may help improve brain function and ability to do daily activities.
- Take it with or without food, preferably at night before going to bed.
- It may cause diarrhea, nausea, and vomiting. Drink plenty of fluids to keep yourself hydrated while taking Ameloss 5.
- Monitor your body weight regularly as both Ameloss 5 and Alzheimer's disease can cause weight loss.
- Do not drive or do anything that requires mental focus until you know how Ameloss 5 affects you.
- Be cautious while taking this medicine if you suffer from peptic ulcer as it may cause vomiting, stomach bleeding, stomach pain, or discomfort.
- Inform your doctor if you develop muscle tremors, especially if you have Parkinson’s disease.
- Inform your doctor if you experience seizures or convulsions while taking this medicine.
Brief Description
Indication
Mild to moderately, severe dementia in Alzheimer's disease.
Administration
May be taken with or without food.
Adult Dose
Oral
Mild to moderately severe dementia in Alzheimer's disease
Adult: Initially, 5 mg daily at bedtime, increase if necessary up to 10 mg once daily at bedtime after 4-6 wk.
Elderly: Initially, 5 mg daily at bedtime, increase if necessary up to 10 mg once daily at bedtime after 4-6 wk.
Hepatic impairment: A similar dose schedule can be followed for patients with mild to moderate hepatic impairment as clearance of donepezil hydrochloride is not affected by these conditions.
Renal Dose
Renal impairment: A similar dose schedule can be followed for patients with renal impairment as clearance of donepezil hydrochloride is not affected by these conditions.
Contraindication
Donepezil is contraindicated in patients with known hypersensitivity to donepezil hydrochloride or to piperidine derivatives.
Mode of Action
Donepezil reversibly and noncompetitively inhibits centrally-active acetylcholinesterase. It is used for the symptomatic treatment of Alzheimer's disease.
Precaution
Caution when used in patients with sick sinus syndrome or cardiac conduction abnormalities. May increase secretion of gastric acid; caution when used in patients at risk of ulcer disease. Patients with COPD, asthma, history of epilepsy, bladder obstruction, prostatic hypertrophy. May cause dose-related diarrhoea, nausea and/or vomiting which usually resolves after 1-3 wk. Safety and efficacy have not been established in children. Pregnancy, lactation.
Side Effect
Nausea, vomiting, anorexia, wt loss, diarrhoea, insomnia, fatigue, muscle cramps; headache and dizziness; syncope, bradycardia; convulsions; increased liver transaminases; sinoatrial and atrioventricular block; hallucinations, agitation and aggressive behavior; minor increases in plasma creatine kinase; potentially bladder outflow obstruction.
Pregnancy Category Note
Pregnancy
There are no adequate data on developmental risks associated with use in pregnant women
Lactation
There are no data on presence of donepezil or metabolites in human milk, effects on breastfed infant, or on milk production; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed infant from drug or from underlying maternal condition
Interaction
May increase the neurotoxic effect of antipsychotics. Concurrent use with systemic corticosteroids may increase the adverse effects of donepezil. May increase the neuromuscular-blocking effect of succinylcholine. May increase the adverse effects of cholinergic agonists. May increase the bradycardic effect of beta-blockers.
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