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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Fresofol 1%.
SAFE IF PRESCRIBED
Fresofol 1% is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Fresofol 1% is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Fresofol 1% may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Fresofol 1% is safe to use in patients with kidney disease. No dose adjustment of Fresofol 1% is recommended.
However, talk to your doctor if you have any underlying kidney disease. Use of Fresofol 1% can cause green discoloration of urine.
SAFE IF PRESCRIBED
Fresofol 1% is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Fresofol 1% may not be needed in these patients. Please consult your doctor.
Medicine Overview of Fresofol 1% 10mg/ml Injection
Introduction
Fresofol 1% is a general anesthetic. It is used in major surgical procedures. It allows the procedures to be carried out without pain and distress. This injection is used in a hospital setting only. Fresofol 1% is used in general anesthesia. It causes loss of consciousness which is reversible. It is administered under the supervision of a healthcare professional. The most common side effects include headache, vomiting, and nausea. This Fresofol 1% is safe to use in pregnancy, breastfeeding mothers, patients of liver and kidney disease. Inform your doctor if you are on any medications or have any known allergy...
... Show moreUses of Fresofol 1%
- General Anaesthesia
Side effects of Fresofol 1%
Common
- Nausea
- Headache
- Vomiting
- Local site pain
- Slow heart rate
- Decreased blood pressure
How to use Fresofol 1%
Your doctor or nurse will give you this medicine. Kindly do not self-administer.
How Fresofol 1% works
Fresofol 1% is a general anaesthetic. It works by causing reversible loss of consciousness. This allows surgical procedures to be carried out without pain and distress.
Quick Tips
- Fresofol 1% helps induce unconsciousness (sleep) so that surgical operations or other procedures can be performed.
- It is given to you as an injection by your doctor.
- After use, you may still feel sleepy for some time. Do not drive or do anything that requires focus until you are sure the effects have subsided.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
Brief Description
Indication
General anaesthesia, Sedation
Adult Dose
Intravenous Induction and maintenance of general anaesthesia Adult: Induction: 40 mg by inj or infusion every 10 sec. Usual dose: 1.5-2.5 mg/kg. Maintenance: 4-12 mg/kg/hr or intermittent bolus inj of 20-50 mg. Elderly: Including neurosurgical and debilitated patients: Infuse at a rate of 20 mg every 10 sec. Maintenance: 3-6 mg/kg/hr. Usual dose needed: 1-1.5 mg/kg. Sedation Adult: In diagnostic and surgical procedures: Initially, 6-9 mg/kg/hr by infusion given for 3-5 minutes or an alternative dose of 0.5-1 mg/kg by slow inj over 1-5 minutes. Maintenance: 1.5-4.5 mg/kg/hr infusion. Reduce maintenance dose by 20% for high-risk patients needing sedation. For...
... Show moreChild Dose
Intravenous
Anesthesia
Induction
3-16 years: 2.5-3.5 mg/kg IVP over 20-30 sec
Maintenance
2 months to 16 years: 0.125-0.3 mg/kg/min IV
Contraindication
Electroconvulsive therapy, obstetrics. Sedation in children <16 yr. Pregnancy, lactation.
Mode of Action
Short-acting, lipophilic sedative/hypnotic; causes global CNS depression, presumably through agonist actions on GABAa receptors.
Precaution
Paediatrics, elderly, hypovolaemia, epilepsy, lipid disorders, patients with increased intracranial pressure. Avoid rapid bolus doses in high risk patients. Emulsion formulation of propofol 2% should only be used in children >3 yr.
Lactation: Excreted in breast milk; effect on nursing infant not known
Side Effect
>10%
Hypotension (peds 17%; adults 3-26%),Apnea lasting 30-60 sec (peds 10%; adults 24%),Apnea lasting >60 sec (peds 5%; adults 12%),Movement (peds 17%; adults 3-10%),Injection site burning/stinging/pain (peds 10%; adults 18%)
1-10%
Respiratory acidosis during weaning (3-10%),Hypertriglyceridemia (3-10%),Hypertension (peds 8%),Rash (peds 5%; adults 1-3%),Pruritus (1-3%),Arrhythmia (1-3%),Bradycardia (1-3%),Cardiac output decreased (1-3%; concurrent opioid use increases incidence).Tachycardia (1-3%)
<1%
Arterial hypotension,Anaphylaxis,Asystole,Bronchospasm,Cardiac arrest,Seizures,Opisthotic rxn,Pancreatitis,Pulmonary edema,Phlebitis,Thrombosis,Renal tubular toxicity
Potentially Fatal: Apnoea, bradycardia, hypotension, convulsions; anaphylaxis.
Interaction
Reduce dose if given with nitrous oxide or halogenated anaesthetics. Increased sedative, anaesthetic and cardiorespiratory effects when used with other CNS depressants.
