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Centradol ER
Incepta Pharmaceuticals Ltd.
Generic: Tapentadol
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Centradol ER.
CONSULT YOUR DOCTOR
Centradol ER may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Centradol ER is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Centradol ER may cause side effects which could affect your ability to drive.
If you feel drowsy, dizzy, have blurred vision or a slow reaction time while taking Centradol ER, then do not drive.
CAUTION
Centradol ER should be used with caution in patients with kidney disease. Dose adjustment of Centradol ER may be needed. Please consult your doctor.
CAUTION
Centradol ER should be used with caution in patients with severe liver disease. Dose adjustment of Centradol ER may be needed. Please consult your doctor.
Use of Centradol ER is not recommended in patients with severe kidney disease.
Medicine Overview of Centradol ER 100mg Tablet
Introduction
Centradol ER is a medicine used to treat moderate to severe acute pain in adults. It is used to treat many conditions such as headache, fever, period pain, toothache, and colds. It effectively alleviates pain when other treatments fail to relieve your pain. Centradol ER may be prescribed alone or in combination with another medicine. You should take it regularly as advised by your doctor. It can be taken with or without food. Your doctor may change the dose and time between doses according to your pain level and your needs. Do not take more or use it for longer...
... Show moreUses of Centradol ER
- Moderate to severe pain
Side effects of Centradol ER
Common
- Nausea
- Sleepiness
- Vomiting
- Dizziness
How to use Centradol ER
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Centradol ER may be taken with or without food, but it is better to take it at a fixed time.
How Centradol ER works
Centradol ER decreases the perception of pain by blocking the transmission of pain signals to the brain.
What if you forget to take Centradol ER?
If you miss a dose of Centradol ER, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Centradol ER is a strong painkiller which is used in the treatment of moderate to severe pain when other treatments do not treat your pain well enough or you cannot tolerate them.
- The addiction / habit-forming potential of Centradol ER is very high. Take exactly as prescribed by your doctor.
- Use caution while driving or doing anything that requires concentration as Centradol ER can cause dizziness and sleepiness.
- While taking this medication, avoid alcohol in all forms including beer, wine, aftershave lotions, mouthwash, vinegar, certain desserts, colognes, and liquid medications.
- Inform your doctor if you have asthma, liver, kidney or pancreatic disease, or are severely constipated.
Brief Description
Indication
Acute Moderate-to-Severe Pain, Musculoskeletal pain, Diabetic Peripheral Neuropathy
Administration
May be taken with or without food.
Adult Dose
Oral
Moderate to severe acute pain
Adult: Initially, 50 mg, 75 mg or 100 mg 4-6 hrly, depending on pain intensity.
On day 1, a 2nd dose may be given 1 hr after the initial dose if pain relief is inadequate; subsequent dose may be given 4-6 hrly, adjust according to response.
Max: 700 mg on day 1, 600 mg daily on subsequent days.
Elderly: Initiate dosage at lower end of range
Hepatic impairment
Mild: Dosage adjustment not required
Moderate: 50 mg q8hr initially; dosing frequency not to exceed 3 times daily;
Severe: Not recommended
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment
CrCl >30 mL/min : Dosage adjustment not required
CrCl <30 mL/min: Not recommended
Contraindication
Significant resp depression (in unmonitored settings or absence of resuscitative equipment), acute or severe bronchial asthma or hypercapnia, known or suspected paralytic ileus; acute intoxication w/ alcohol, hypnotics, centrally acting analgesics or psychotropic active substances. Concurrent or recent (w/in 2 wk) therapy w/ MAOIs.
Mode of Action
Mu-opioid agonist; inhibits ascending pain pathways, thus altering response to pain; produces analgesia, respiratory depression, and sedation; also inhibits reuptake of norepinephrine, which also affects ascending pain pathways.
Precaution
Tapentadol should be administered with caution to patients with conditions accompanied by hypoxia, hypercapnia, respiratory problems such as: asthma, chronic obstructive pulmonary disease etc. Besides this, in case of patient with sleep apnea syndrome, myxedema, kyphoscoliosis, central nervous system (CNS) depression should have to be cautious prior administration of Tapentadol. Patients receiving other µ-opioid agonist analgesics, general anesthetics, phenothiazines, other tranquilizers, sedatives, hypnotics, or other CNS depressants (including alcohol) concomitantly with Tapentadol may exhibit additive CNS depression.
Side Effect
>10%
Nausea (30%),Dizziness (24%),Vomiting (18%),Somnolence (15%)
1-10% (selected)
Constipation (8%),Pruritus (5%),Xerostomia (4%),Fatigue (3%),Hyperhidrosis (3%),Anorexia (2%),Dyspepsia (2%),Insomnia (2%)
Interaction
Potential severe adverse effects w/ MAOIs. CNS-active drugs; other serotonergic agents (including triptans, SSRIs, other SNRIs, lithium, sibutramine, fentanyl & its analogues, tramadol, dextromethorphan, tapentadol, meperidine, methadone, pentazocine or St. John's wort), drugs which impair serotonin (eg linezolid & methylene blue) or serotonin precursors (eg tryptophan supplements). Increased risk of QTc prolongation &/or ventricular arrhythmias w/ some antipsychotics & antibiotics. Decreased AUC & Cmax of indinavir. Increased AUC & Cmax of haloperidol. Increased plasma conc w/ ketoconazole. Increased plasma conc & reduced BP-lowering effect of metoprolol. Increased AUC of risperidone. Reduced metabolism w/ CYP2D6 inhibitors. Increased venlafaxine levels w/ CYP3A4...
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