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Combomax
Drug International Ltd.
Generic: Tamsulosin + Dutasteride
Safety Advices
বাংলা
English
UNSAFE
Combomax may cause excessive drowsiness with alcohol.
UNSAFE
Combomax is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
Information regarding the use of Combomax during breastfeeding is not available. Please consult your doctor.
SAFE
Combomax does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Combomax is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Combomax may not be needed in these patients. Please consult your doctor.
CAUTION
Combomax should be used with caution in patients with liver disease. Dose adjustment of Combomax may be needed. Please consult your doctor.
Use of Combomax is not recommended in patients with severe liver disease.
Medicine Overview of Combomax 400mcg+500mcg Capsule
Introduction
Combomax is a combination of two medicines which work in different ways to treat men with an enlarged prostate gland. It helps to relieve symptoms such as difficulty urinating or needing to go to the toilet more often. It is not used to prevent prostate cancer. Combomax maybe taken with or without food but it should be taken at the same time each day. Your doctor will prescribe the dose most suitable for you. To gain the most benefit and to treat your symptoms effectively, you should not miss doses, even if you feel well. It may take up to...
... Show moreUses of Combomax
- Benign prostatic hyperplasia
Side effects of Combomax
Common
- Impotence
- Decreased libido
- Breast pain
- Ejaculation disorder
- Dizziness
How to use Combomax
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Combomax may be taken with or without food, but it is better to take it at a fixed time.
How Combomax works
Combomax is a combination of two medicines: Tamsulosin and Dutasteride, which relieves the symptoms of benign prostatic hyperplasia. Tamsulosin is an alpha-blocker. It works by relaxing the muscle around the bladder exit and prostate gland so as to allow easy passage of urine. Dutasteride is a 5-alpha-reductase inhibitor which helps in shrinking the prostate gland by decreasing the level of the hormone which helps the prostate gland grow.
What if you forget to take Combomax?
If you miss a dose of Combomax, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Urimax D Tablet MR to relieve the symptoms of benign prostatic hyperplasia (BPH).
- Take it approximately 30 minutes after the same meal each day.
- Urimax D Tablet MR may cause dizziness or blurring of vision. Do not drive or do anything requiring concentration until you know how it affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- If you are scheduled to undergo an eye surgery due to cataract or glaucoma, inform your eye doctor about the usage of Urimax D Tablet MR.
- It may cause difficulty achieving or maintaining an erection (impotence), decreased sex drive, and ejaculation disorders such as decreased amount of semen produced or decreased sperm count.
- Do not donate blood for 6 months after taking the last dose of Urimax D Tablet MR.
Brief Description
Indication
Benign prostatic hyperplasia
Adult Dose
Oral
Benign prostatic hyperplasia
Adult: 1 cap once daily.
Contraindication
Hypersensitivity, severe liver impairment. Pregnancy, lactation, child, adolescent.
Mode of Action
Tamsulosin is a selective alpha-1 adrenoceptor blocker. It blocks alpha-1 adrenoceptors, which are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck, resulting relaxation of these adrenoceptors in the bladder neck and prostate. Thus, there is an improvement in urine flow rate and reduction in symptoms of benign prostatic hypertrophy (BPH). Dutasteride inhibits 5 alpha-reductase, the enzyme responsible for conversion of testosterone to 5 alpha-dihydrotestosterone (DHT). DHT appears to be the principal androgen responsible for stimulation of prostatic growth.
Precaution
Excreted in semen therefore use of condom is recommended. Women of childbearing potential should avoid handling leaking capsules of dutasteride. Prostate carcinoma should be ruled out before starting the therapy. Blood donation to be avoided during and at least 6 mths after discontinuance of drug.
Side Effect
>10%
Orthostasis (16%)
1-10%
Ejaculation disorders (10%),Dizziness (2%),Breast enlargement/tenderness (3%),Impotence (8%),Decreased libido (4.5%),Breast disorders (1%)
<1%
Prostate cancer (high grade)
Interaction
Concomitant admin with moderate or strong inhibitors of CYP2D6 (eg. fluoxetine) or CYP34A (eg. ketoconazole, cimetidine) increases tamsulosin serum concentration; increase in blood concentrations of dutasteride in the presence of inhibitors of CYP3A4/5 such as ritonavir, ketoconazole, verapamil, diltiazem, cimetidine, troleandomycin, and ciprofloxacin.
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