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Propanthene
Gaco Pharmaceuticals(G.A Company Ltd)
Generic: Propantheline Bromide
Medicine Overview of Propanthene 15mg Tablet
বাংলা
English
Indication
Hyperhidrosis, Peptic ulcer, Urinary incontinence, GI tract spasm, Adult enuresis
Administration
Should be taken on an empty stomach. Take ½ hr before meals.
Adult Dose
Oral
Adjunct in peptic ulcer; Gastrointestinal tract spasm
Adult: 15 mg tid and 30 mg at bedtime. Doses up to 120 mg daily may be needed.
Elderly: 7.5 mg tid. May increase to a max of 30 mg tid.
Urinary incontinence; Adult enuresis; Hyperhidrosis
Adult: 15-30 mg bid/tid.
Child Dose
Oral
Adjunct in peptic ulcer; Gastrointestinal tract spasm
Child: For relief of GI spasm: 1 mth - 12 yr: 300 mcg/kg (max 15 mg), given 3-4 times daily.
Contraindication
Glaucoma, obstructive diseases of GI or urinary tract, severe ulcerative colitis or toxic megacolon, intestinal atony, hiatus hernia associated with reflux oesophagitis, unstable cardiovascular adjustment in acute bleeding, prostatic enlargement, myasthenia gravis, paralytic ileus, pyloric stenosis, angle-closure glaucoma.
Mode of Action
Propantheline bromide is a quarternary ammonium antimuscarinic with antisecretory and antispasmodic effects.
Precaution
Hyperthyroidism, congestive heart failure, coronary heart disease, cardiac arrhythmias, acute MI, cardiac insufficiency, hypertension. Pregnancy and lactation; elderly. Patients with fever, diarrhoea, GI reflux disease or ulcerative colitis. Hepatic or renal impairment. Increased risk of fever or heat stroke in patients exposed to high environmental temperature. Caution when used in patients with Down's syndrome.
Side Effect
>10%
Constipation,Dry mouth,Dry skin,Decreased sweating
Frequency Not Defined
Blurred vision,Sedation,Tachycardia,Dysphagia,Urinary retention
Potentially Fatal: Toxic megacolon due to preexisting ulcerative colitis.
Interaction
Additive anticholinergic effect with MAOIs, TCAs, phenothiazines, antihistamines and disopyramide. Delayed gastric emptying causes delayed absorption of other drugs. May antagonise the GI effects of domperidone, cisapride and metoclopramide. May reduce absorption of ketoconazole and levodopa. May increase absorption of nitrofurantoin. May increase serum levels of digoxin. May reduce effects of haloperidol and sublingual tablets of nitrates. May antagonise effects of parasympathomimetics.
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