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Bleocin

Injection-(15mg/vial)
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Rainbow Traders

Generic: Bleomycin

1 Injection
৳ 1019.68
৳ 1121.75
9% OFF

Medicine Overview of Bleocin 15mg/vial Injection

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Introduction

Bleocin is a medicine used for treatment of cancer in various parts of the body such as cervical, Cancer of the mouth, nasopharynx and paranasal sinuses, larynx, esophagus, and skin. It works by interfering with the growth of cancer cells, which are eventually destroyed. Bleocin may be used alone or with other medicines as part of combination therapy.It is given under the supervision of a healthcare professional and should not be self-administered. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid drinking alcohol as it may increase your risk of liver damage. The most common side effects of this medicine include fever, loss of appetite, loss of hair, weight loss, nausea, inflammation of the lungs (interstitial pneumonia), shortness of breath or cough. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Your doctor will advise you regular blood tests to check for these. Before taking it, tell your doctor if you have stomach, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Your doctor may perform several tests such as blood tests, X-rays and physical examinations both before and during treatment with this medicine.

Uses of Bleocin

  • Cervical cancer
  • Cancer of mouth, nasopharynx and paranasal sinuses, larynx, oesophagus
  • Skin cancer

Side effects of Bleocin

Common
  • Fever
  • Hair loss
  • Interstitial pneumonia
  • Loss of appetite
  • Low blood platelets
  • Nail discoloration
  • Nausea
  • Pulmonary fibrosis
  • Rigors
  • Scratch dermatitis
  • Skin pigmentation
  • Stomatitis (Inflammation of the mouth)
  • Vomiting
  • Weight loss

How to use Bleocin

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Bleocin works

Bleocin is an anti-cancer medication. It works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.

Quick Tips

  • Inform your doctor before taking bleomycin if you have severe heart disease, kidney problems, lung problems requiring use of oxygen, impaired liver function, and chicken pox or if you are about to undergo a surgery.
  • Inform your doctor before taking bleomycin if you are taking other anticancer/cytotoxic drugs such as vinca alkaloids or cisplatin, drugs such as clozapine or if you have received radiation in the chest area.
  • Seek immediate medical advice if you develop dry cough, breathlessness, rapid breathing or any other lung problems.
  • Do not drive or operate heavy machinery after taking this drug as it may make you feel weak or tired.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Brief Description

Indication

Lymphoma, Squamous cell or Testicular tumours, Malignant effusions

Administration

IV/IM Preparation IV: reconstitute 15 U vial in 5 mL & 30 U vial in 10 mL NS to yield 3 U/mL solution IM/SC: reconstitute 15 U vial in 1-5 mL & 30 U vial in 2-10 mL NS/SWI/BWI Do not use dextrose-containing diluents Although may be stable for longer periods, preferably use within 24 hr of reconstitution In lymphoma patients, give first 2 doses at 1-2 units to test for anaphylactoid reaction Limit lifetime dose to <400 units because of risk of pulmonary fibrosis Low ADRs w/intrapleural administration

Adult Dose

Squamous Cell Carcinoma, Testicular Carcinoma 0.25-0.5 unit/kg (10 to 20 unit/m²) IV/IM/SC q1-2Weeks Hodgkin's Disease, Non-Hodgkin's Lymphoma Administer test dose of 1-2 units of bleomycin before first 1-2 doses; monitor vital signs q15min; wait 1 hour minimum before administering remainder of dose; if no acute reaction observe, may administer regular dosage schedule 0.25 to 0.5 unit/kg (10 to 20 unit/m²) IV/IM/SC q1-2Weeks; reduce to maintenance dose of 1 unit qDay or 5 unit qWeek IV/IM after 50% response Hepatic Impairment: Dose adjustment not necessary

Child Dose

Not recommended

Renal Dose

Renal Impairment CrCl >50 mL/min: Dose adjustment not necessary CrCl 40-50 mL/min: 70% of normal dose CrCl 30-40 mL/min: 60% of normal dose CrCl 20-30 mL/min: 55% normal dose CrCl 10-20 mL/min: 45% normal dose CrCl 5-10 mL/min: 40% normal dose

Contraindication

Hypersensitivity. Severe pulmonary disease; pregnancy and lactation.

Mode of Action

Bleomycin causes breakage of single- and double- stranded DNA by binding to DNA and inhibiting DNA synthesis. To a lesser extent, it also inhibits RNA and protein synthesis. It causes very little bone marrow suppression.

Precaution

Pulmonary infection, preexisting pulmonary function impairment, renal impairment. Patients who received radiotherapy, particularly to the thorax. Regular chest x-rays should be done. Elderly. Discontinue treatment if chest x-rays show infiltrates or breathlessness occurs. Lactation: It is not known whether the drug is excreted in milk. Because of the potential for serious adverse reactions in nursing infants, it is recommended that nursing be discontinued by women receiving bleomycin therapy.

Side Effect

>10% Mucocutaneous toxicity including rash, erythema, hyperpigmentation, urticaria (>50%),Febrile reactions, acute (25-50%),Mucositis (30%),Stomatitis (30%),Interstitial pneumonitis (10%),Pulmonary fibrosis (10%),Anorexia,Weight loss,Rales,Tachypnea 1-10% Alopecia (1-10%),Fatal pulmonary fibrosis (1%),Confusion,Shivering,Anphylactoid rxns,Onycholysis,Pruritus,Skin thickening,Skleroderma <1% Nausea,Malaise,Myocardial infarction,Hypotension,Cerebral vascular accident,Raynaud's phenomenon,Fatal pulmonary fibrosis,Hepatotoxicity,Renal toxicity,Necrolysis,Hyperpigmentation Potentially Fatal: Pulmonary toxicity, interstitial pneumonitis, fibrosis, cardiorespiratory collapse in patients with lymphoma.

Pregnancy Category Note

Pregnancy Category: D Lactation: It is not known whether the drug is excreted in milk. Because of the potential for serious adverse reactions in nursing infants, it is recommended that nursing be discontinued by women receiving bleomycin therapy.

Interaction

Increased incidence and severity of lung toxicity w/ previous or concurrent radiotherapy to the chest. Combination w/ vinca alkaloids may result to a syndrome corresponding to morbus Raynaud, ischaemia which can lead to necrosis of peripheral parts of the body (fingers, toes, nose tip). May reduce the absorption of phenytoin. Increased risk of agranulocytosis w/ clozapine. Potentially Fatal: Increased pulmonary toxicity w/ oxygen, cisplatin or brentuximab.

Buy Bleocin from Arogga

In Bangladesh, you can get the original Bleocin. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Bleocin in Bangladesh?

The latest price of Bleocin in Bangladesh is 1019.68৳. You can buy Bleocin at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Bleocin. Please consult your doctor.
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CONSULT YOUR DOCTOR
Bleocin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
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CONSULT YOUR DOCTOR
Bleocin is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
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UNSAFE
Bleocin may cause side effects which could affect your ability to drive. As with $med_name, few people have reported that they feel tired or weak after the treatment so it may affect your driving ability.
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CAUTION
Bleocin should be used with caution in patients with kidney disease. Dose adjustment of Bleocin may be needed. Please consult your doctor.
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SAFE IF PRESCRIBED
Bleocin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Bleocin may not be needed in these patients. Please consult your doctor.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.