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Medicine Overview of HMG IM/SC Injection 75IU Vial Injection
বাংলা
English
Indication
Female infertility, Male infertility, In vitro fertilisation procedures or other assisted conception techniques
Adult Dose
Parenteral Female infertility Adult: 75-150 units of FSH daily via IM or SC inj; adjust gradually until adequate response is achieved. Treatment is stopped and followed after 1 or 2 days by single dose of chorionic gonadotrophin 5000-10,000 units. In menstruating patients, start within the 1st 7 days of menstrual cycle. Alternatively, 3 equal doses IM or SC, each providing 225-375 units of FSH on alternate days followed by chorionic gonadotrophin 1 wk after the 1st dose. Stop treatment if no response is seen in 3 wk. Course may be repeated twice more, if necessary. Male infertility Adult: Stimulate spermatogenesis...
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Contraindication
Ovarian cysts or enlargement not caused by polycystic ovarian syndrome; tumors of breast, uterus, ovaries, testes or prostate; vaginal bleeding of unknown cause; pregnancy and lactation.
Mode of Action
Human menopausal gonadotrophins possess both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activities.
Precaution
Hyperprolactinemia or tumors of the pituitary or hypothalamus. Ovarian enlargement at risk of rupture, care in pelvic examinations. Risk of multiple births.
Side Effect
Ovarian hyperstimulation, risk of multiple pregnancy and miscarriage, hypersensitivity and local reactions at Inj site, nausea, vomiting, joint pain, fever. In men, gynecomastia, acne, weight gain.
Potentially Fatal: Rupture of ovarian cysts and intraperitoneal haemorrhage.
Interaction
Drugs with luteinising hormone activity may increase risk of ovarian hyperstimulation syndrome.
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