Folate (6s-5-methyltetrahydrofolate) may show possible drug interactions. Anticonvulsant action of phenytoin is antagonized by Folic Acid. Folate deficiency may result from increased loss of folate, as in renal dialysis and/or interference with metabolism (e.g., Folic Acid antagonists such as Methotrex- ate); the administration of anticonvulsants, such as diphenylhydantoin, primidone, and barbiturates; alcohol consumption and, especially alcoholic cirrhosis; and the administration of pyrimethamine and, nitrofurantoin. Taking Folate (6s-5-methyltetrahydrofolate) along with amiodarone might increase the chances of sunburn, blistering, or rashes on areas of skin exposed to sunlight. Folate (6s-5-methyltetrahydrofolate) might increase breaks down of phenobarbital leading to decrease the effectiveness of...
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