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Mes-D

Injection-(400mg/4ml)
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Drug International Ltd.

Generic: Mesna Disulfide

1 Injection
৳ 176.55
৳ 190
7% OFF

Medicine Overview of Mes-D 400mg/4ml Injection

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Introduction

Mes-D is used to prevent ifosfamide-induced hemorrhagic cystitis. But, its not used to reduce the risk of blood in the urine due to other medical conditions. It only helps to reduce the risk of inflammation and bleeding in the bladder, who receive ifosfamide. Mes-D is given under the supervision of doctor. It is taken in a dose as advised by the doctor. The duration of treatment varies on the basis of your need and response to treatment. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Some common side effects of this medicine include nausea, headache, and lightheadedness. It is advised to drink at least 1 liter of fluid daily when you are on treatment with this medicine. You should seek immediate medical attention if you experience severe allergic reactions like rash, itching, breathing difficulty, chest tightness and swelling of the mouth, face, lips, or tongue while taking this medicine. Regular blood tests are required to check your blood cells along with kidney, liver, and blood uric acid levels. Before taking it, tell your doctor if you have autoimmune disorder, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Mes-D

  • Ifosfamide-induced hemorrhagic cystitis

Side effects of Mes-D

Common
  • Nausea
  • Headache
  • Lightheadedness
  • Lethargy
  • Abdominal pain
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Diarrhea
  • Rash
  • Fever
  • Flu-like symptoms

How to use Mes-D

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Mes-D works

Mes-D helps to reduce the risk of inflammation and bleeding in the bladder, who receive ifosfamide (a medicine used to treat cancer).

Quick Tips

  • Drink at least 1 litre of fluid daily while you are receiving mesna.
  • Seek immediate medical attention if you experience severe allergic reactions like rash, itching, breathing difficulty, chest tightness, and swelling of the mouth, face, lips, or tongue while taking mesna.
  • Do not drive or operate machinery as mesna may cause drowsiness, dizziness, blurred vision, or light headedness.
  • Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding.
  • You will be monitored for blood or protein in urine during the treatment of mesna.
  • Do not take if allergic to mesna or any of its ingredients (thiol containing compound)

Brief Description

Indication

Urothelial toxicity

Administration

IV Preparation Reconstitute w/ D5W, NS, dextrose/saline or LR to a final concentration of 20 mg/mL IV Administration IVP: bolus 15 min before ifosfamide Intermittent infusion over 15-30 min Continuous Infusion: may be added to ifosfamide/cyclophosphamide in infusion bag Additive compatibility w/ cyclophosphamide shown only in D5W & LR

Adult Dose

Intravenous Prophylaxis against urothelial toxicity With Ifosfamide 240 mg/sq.meter (if receiving 1.2 g/sq.meter ifosfamide dose) IVP 15 minutes before & 4 & 8 hours after ifosfamide admin OR 240 mg/sq.meter (if receiving 1.2 g/sq.meter ifosfamide dose) IVP 15 minutes before & 480 mg/sq.meter PO 2 & 6 hours after ifosfamide admin Adjust dose accordingly if ifosfamide dose changes Also given by alternative IVP regimens, intermittent infusion or continuous infusion-

Contraindication

Hypersensitivity to thiol-containing compounds.

Mode of Action

Mesna is used to prevent urothelial toxicity associated with oxazaphosphorine, ifosfamide or cyclophosphamide. It acts in the kidney; reacting with thiol groups of urotoxic metabolites (e.g. acrolein) of ifosfamide and cyclophosphamide. It is used as a mucolytic in the management of some respiratory tract conditions e.g. cystic fibrosis where other mucolytics have failed. It acts by reducing the viscosity of pulmonary secretions; the drug's free sulfhydryl group is thought to reduce disulfide linkages of mucoproteins.

Precaution

Protective effect applies only to the urinary tract; pregnancy, lactation. Patients with auto-immune disorders. IV formulation may contain benzyl alcohol as a preservative; avoid in neonates or infants. Instruct patients to seek medical attention if discolouration of urine occurs. During treatment, monitor urine for erythrocytes and haematuria. Maintain adequate hydration in all patients. Patients who vomit within 2 hr of oral dose should repeat dose or receive IV dose. Lactation: not known if excreted in breast milk, do not nurse

Side Effect

>10% Nausea (>50%),Vomiting (29%),Anorexia.Asthenia,Fatigue,Fever,Abdominal pain,Constipation,Anemia,Granulocytopenia,Leukopenia,Thrombocytopenia,Alopecia 1-10% Anxiety,Confusion,Dizziness,Headache,Insomnia,Pain,Somnolence,Chest pain,Edema,Flushing,Tachycardia,Cough,Dyspnea,Pneumonia,Diarrhea,Hematuria,Hypokalemia,Back pain,Dehydration,Injection site reaction,Pallor Potentially Fatal: May cause haemorrhagic cystitis, systemic anaphylactic reactions.

Interaction

Mesna is incompatible in vitro with cisplatin and nitrogen mustard.

Buy Mes-D from Arogga

In Bangladesh, you can get the original Mes-D. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Mes-D in Bangladesh?

The latest price of Mes-D in Bangladesh is 176.55৳. You can buy Mes-D at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Mes-D. Please consult your doctor.
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SAFE IF PRESCRIBED
Mes-D is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
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UNSAFE
Mes-D is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
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UNSAFE
Mes-D may cause side effects which could affect your ability to drive. As patients undergoing treatment with Mes-D may experience undesirable effects such as lightheadedness, lethargy, dizziness, and blurred vision which could affect the ability to drive.
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CONSULT YOUR DOCTOR
There is limited information available on the use of Mes-D in patients with kidney disease. Please consult your doctor.
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CONSULT YOUR DOCTOR
There is limited information available on the use of Mes-D in patients with liver disease. Please consult your doctor.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.