Epiruba-50 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Epiruba-50 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Epiruba-50 may cause side effects which could affect your ability to drive.
Epiruba-50 may cause episodes of nausea and vomiting, which can temporarily lead to an impairment of the ability to drive.
SAFE IF PRESCRIBED
Epiruba-50 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Epiruba-50 may not be needed in these patients. Please consult your doctor.
Lower doses may be considered in patients with serum creatinine > 5 mg/dL.
CAUTION
Epiruba-50 should be used with caution in patients with liver disease. Dose adjustment of Epiruba-50 may be needed. Please consult your doctor.
Use of Epiruba-50 is not recommended in patients with severe liver disease.
Medicine Overview of Epiruba-50 2mg/ml Injection
Introduction
Epiruba-50 is used in the treatment of various types of cancers of blood, breast, stomach, lung, ovaries and soft tissues. It also helps to prevent the recurrence of bladder cancer after surgery.
It is given as a drip or infusion vein with extreme c...
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Uses of Epiruba-50
Cancer
Side effects of Epiruba-50
Common
Low blood platelets
Nausea
Hair loss
Absence of menstrual periods
Fever
Anemia (low number of red blood cells)
Diarrhea
Weight loss
Decreased white blood cell count (neutrophils)
Hot flashes
Gastrointestinal inflammation
Rash
Low energy
Eye disorder
How to use Epiruba-50
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Epiruba-50 works
Epiruba-50 is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase II) involved in DNA multiplication of the breast cancer cells. It also forms harmful chemicals (free radicals) which cause DNA damage. This slow...
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Quick Tips
Epiruba-50 is used alone or in combination with other medicines for the treatment of various types of cancers.
It is given through a drip into a vein (intravenous infusion) by a doctor or nurse.
It may make you feel tired or sleepy. Do not drive or do anything that requires mental focus until you know how it affects you.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for 6 months after stopping treatment.
Your doctor may get regular blood tests done to monitor your blood cells, liver, and heart function during treatment with this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
Brief Description
Indication
Acute leukaemias; Lymphoma; Multiple myeloma, Breast cancer, Bladder carcinoma
Administration
IV Administration
Administer infuse into tubing of a freely flowing infusion (NS or D5W) over 3-5 min
Avoid extravasation, associated with severe ul...
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Adult Dose
Adjuvant Breast Cancer Treatment
Option 1 (Day 1 dose schedule)
Day 1: Epirubicin 100 mg/m² IV, AND 5-fluorouracil 500 mg/m² IV, AND cyclophosphamid...
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Child Dose
Safety & efficacy not established
Renal Dose
Renal Impairment
SCr >5 mg/dL [>442 micromoles/L]: Decrease dose by 50%; test cardiac ejection fraction via MUGA before starting treatment
Contraindication
Cardiac impairment, severe or recent MI; previous full cumulative doses of anthracyclines. Hypersensitivity; severe hepatic dysfunction. Not for intra...
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Mode of Action
Epirubicin, an anthracycline with cytotoxic properties. It inhibits DNA and RNA synthesis by steric obstruction after intercalating between DNA base p...
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Precaution
Previous extensive radiotherapy, bone infiltration by tumour, severe renal and hepatic dysfunction. May cause tumor lysis syndrome or radiation recall...
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Side Effect
>10%
Alopecia (96%),Nausea and vomiting (92%),Leukopenia or neutropenia (80%),Amenorrhea (72%),Anemia (72%),Mucositis (59%),Thrombocytopenia (49%),Le...
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Pregnancy Category Note
Pregnancy
Verify pregnancy status in female patients of reproductive potential prior to initiating
Based on findings from animal studies and mecha...
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Interaction
Paclitaxel and other anthracyclines. Cimetidine, heparin. Antineoplastic drugs, cardiotoxic drugs, radiation, hepatoactive drugs.
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.