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Leptal 300
Healthcare Pharmaceuticals Ltd.
Generic: Oxcarbazepine
Safety Advices
বাংলা
English
UNSAFE
Leptal 300 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Leptal 300 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Leptal 300 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Baby should be monitored for excessive sleepiness and weight gain.
UNSAFE
Leptal 300 may cause side effects which could affect your ability to drive.
Leptal 300 may make you feel sleepy or dizzy, or may cause blurred vision, lack of muscle coordination, especially when starting treatment or increasing the dose. This may affect your driving ability.
CAUTION
Leptal 300 should be used with caution in patients with kidney disease. Dose adjustment of Leptal 300 may be needed. Please consult your doctor.
CAUTION
Leptal 300 should be used with caution in patients with severe liver disease. Dose adjustment of Leptal 300 may be needed. Please consult your doctor.
Dose adjustment is not recommended in patients with mild to moderate liver disease.
Medicine Overview of Leptal 300mg Tablet
Introduction
Leptal 300 is a prescription medicine used to treat and prevent epilepsy (seizures). However, it cannot cure epilepsy and will only work to prevent seizures for as long as you continue to take the medicine. Leptal 300 may be used alone or in combination with other medicines. The dose and how often you need to take it will be decided by your doctor so that you get the right amount to control your symptoms. It may be increased gradually. You can take this medicine with or without food but take it at the same time each day to get the...
... Show moreUses of Leptal 300
- Epilepsy/Seizures
Side effects of Leptal 300
Common
- Headache
- Nausea
- Vomiting
- Double vision
- Fatigue
- Dizziness
- Impaired coordination
- Nystagmus (involuntary eye movement)
- Tremor
- Abnormal vision
- Altered walking
- Sleepiness
How to use Leptal 300
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Leptal 300 may be taken with or without food, but it is better to take it at a fixed time.
How Leptal 300 works
Leptal 300 is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.
What if you forget to take Leptal 300?
If you miss a dose of Leptal 300, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
- Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
- Some healthy tips to prevent seizures:
- It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
- It may increase the risk of low sodium levels in the blood. Inform your doctor if you develop difficulty concentrating, memory problems, confusion, weakness, and unsteadiness.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Brief Description
Indication
Partial seizures, Generalised tonic-clonic seizures
Administration
May be taken with or without food.
Adult Dose
Oral Partial seizures Adult: Adjunctive treatment 300 mg PO q12hr initially; may increase at weekly intervals by 600 mg/day up to 1200 mg/day Monotherapy (if converting from other AED) Initial: 300 mg PO q12hr; increase by 600 mg/day qWeek up to 2400 mg/day Reduce and withdraw concomitant antiepileptic drugs (AEDs) over 3-6 weeks while reaching maximum oxcarbazepine dose in 2-4 weeks Monotherapy (if AED naive) Initial: 300 mg PO q12hr; increase by 300 mg/day q3Day to 1200 mg/day divided q12hr Diabetic Neuropathy 150-300 mg/day PO initially; may increase to 900-1200 mg/day (general recommendation) Neuralgia/Neuropathy 300 mg PO q8-12hr initially; may...
... Show moreChild Dose
Partial Seizures (Adjunctive Treatment) (age 2-4 years) Initial: 8-10 mg/kg/day PO divided q12hr; not to exceed 600 mg/day 39 kg: 900 mg PO q12hr Partial Seizures (Monotherapy) (age 4-16 years) AED: Initial, 8-10 mg/kg/day PO divided q12hr; may increase qWeek by maximum increment of 10 mg/kg/day AED-naive: Initial 8-10 mg/kg/day PO divided q12hr; may increase q3Days by 5 mg/kg/day Target maintenance: Weight-based dosing may be as high as 2100 mg/day for >60 kg 20-24.99 kg: 600-900 mg/day 25-34.99 kg: 900-1200 mg/day 35-44.99 kg: 900-1500 mg/day 45-49.99 kg: 1200-1500 mg/day 50-59.99 kg: 1200-1800 mg/day 60-69.99 kg: 1200-2100 mg/day 70 kg: 1500-2100...
... Show moreRenal Dose
Renal impairment
CrCl <30 mL/min: Decrease initial dose by 50%, titrate up slowly
Contraindication
Hypersensitivity. Lactation.
Mode of Action
Oxcarbazepine blocks voltage-sensitive sodium channels, which inhibits repetitive firing, stabilises hyperexcited neuronal membranes and decreases release of synaptic impulses. These effects may prevent the spread of epileptic seizures.
Precaution
Patient carrying the HLA-B*1502 allele. Avoid abrupt withdrawal. Severe renal and hepatic impairment. Pregnancy. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor seizure frequency, serum Na, symptoms of CNS depression, hypersensitivity reactions, serum levels of concomitant antiepileptic drugs during titration; periodic thyroid function test and CBC. Lactation: Oxcarbazepine and its active metabolite (MHD) are excreted in human milk; milk-to-plasma concentration ratio of 0.5 was found for both Because of the potential for serious adverse reactions in nursing infants, a decision should be made as to whether a mother should discontinue nursing or whether she should...
... Show moreSide Effect
>10%
Dizziness (30-50%),Diplopia (30-50%),Headache (26-30%),Nausea/vomiting (26-30%),Nystagmus (26-30%),Somnolence (26-30%),Ataxia (10-30%),Abnormal gait (16-20%),Tremor (16-20%),Abdominal pain (11-15%),Fatigue (11-15%),Vertigo (11-15%),Vision abnormalities (11-15%)
1-10%
Dyspepsia (5-6%),Rash (4%),Insomnia (2-4%),Abnormal thinking (<4%),Hyponatremia (1-3%),Muscle weakness (1-2%),Hypotension (<2%),Speech disorder (1%),Asthenia
Interaction
Reduced serum levels with carbamazepine, phenobarbitone, phenytoin, valproic acid. May reduce levels/effects of CYP3A4 substrates (e.g. benzodiazepines, calcium channel blockers, clarithromycin, ciclosporin, erythromycin, oestrogens, mirtazapine, nateglinide, nefazodone, nevirapine, protease inhibitors, tacrolimus, venlafaxine). May reduce efficacy of oral contraceptives. May reduce levels/effects of maraviroc. May increase levels of phenobarbitone, phenytoin.
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