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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Briva 25.
CONSULT YOUR DOCTOR
Briva 25 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Briva 25 during breastfeeding is not available. Please consult your doctor.
UNSAFE
Briva 25 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Briva 25 is safe to use in patients with kidney disease. No dose adjustment of Briva 25 is recommended.
It is not recommended in end-stage renal disease due to a lack of clinical trial data.
CAUTION
Briva 25 should be used with caution in patients with liver disease. Dose adjustment of Briva 25 may be needed. Please consult your doctor.
Medicine Overview of Briva 25mg Tablet
Introduction
Briva 25 is an anti-epileptic medicine used to treat seizures (fits) in epilepsy. It can be used alone or along with other medicines. It helps to prevent seizures for as long as you continue to take it. Briva 25 suppresses the abnormal electrical activity in the brain. You can take it regularly with or without food but try to take it at the same time each day to get the most benefit. The dose and how often you need it will be decided by your doctor so that you get the right amount to control your seizures. It may be...
... Show moreUses of Briva 25
- Epilepsy/Seizures
Side effects of Briva 25
Common
- Dizziness
- Fatigue
- Nausea
- Sleepiness
- Vomiting
- Constipation
- Irritation
How to use Briva 25
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Briva 25 may be taken with or without food, but it is better to take it at a fixed time.
How Briva 25 works
Briva 25 is an antiepileptic medication. It works by attaching itself to specific sites (SV2A) on the surfaces of nerve cells. This suppresses the abnormal activity of the nerve cells in the brain and prevents the spread of electrical signals that cause seizures.
Quick Tips
- Briva 25 should be taken regularly as directed by your doctor as missing doses can trigger seizures.
- Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
- Some healthy tips to prevent seizures:
- It may cause sleepiness or drowsiness. If this happens to you, do not drive or use machinery.
- Inform your doctor if you have a history of liver disease, kidney disease or drug abuse.
- Do not stop using Briva 25 without talking to your doctor, even if you feel better.
Brief Description
Indication
Partial-Onset Seizures, Adjunctive therapy in treating partial-onset seizures w/ or w/o secondary generalisation in adults & adolescents ≥16 yr w/ epilepsy.
Adult Dose
Partial-Onset Seizures
Indicated for partial-onset seizures
50 mg PO/IV q12hr initially; based on individual patient tolerability and therapeutic response, adjust dose between to 25-100 mg PO/IV BID (50-200 mg/day)
Injection may be used for patients when oral administration is temporarily not feasible; clinical study experience with injection is limited to 4 consecutive days of treatment
Hepatic impairment
All stages: Decrease starting dose to 25 mg BID and do not exceed 75 mg BID (150 mg/day)
Child Dose
Partial Onset Seizures Tablets or oral solution Indicated for partial-onset seizures in children and adolescents ?4 years 16 years 50 mg PO BID (100 mg/day) initially; based on individual patient tolerability and therapeutic response, adjust dose between to 25-100 mg PO BID (50-200 mg/day) Injection Indicated for partial-onset seizures in adolescents ?16 years with epilepsy Injection may be used for patients when oral administration is temporarily not feasible 16 years: 50 mg IV q12hr initially; based on individual patient tolerability and therapeutic response, adjust dose between to 25-100 mg IV BID (50-200 mg/day) Clinical study experience with injection is limited...
... Show moreRenal Dose
Renal impairment
Mild-to-moderate: No dose adjustment required
ESRD undergoing dialysis: Not studied
Contraindication
Hypersensitivity; bronchospasms and angioedema have occurred
Mode of Action
Exact mechanism unknown
Displays a high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain, which may contribute to the anticonvulsant effect
Precaution
Monitor patients for signs of suicidal ideation & behaviours. Minor or moderate influence on the ability to drive & use machines. Hepatic impairment. Not recommended in end-stage renal disease patients undergoing dialysis. Women of childbearing potential. Pregnancy & lactation. Elderly ≥65 yr. Childn <16 yr. FC tab: Rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Oral soln: Rare hereditary problems of fructose intolerance. Contains methyl parahydroxybenzoate (E218). Oral soln & vial: Patients on controlled Na diet.
Side Effect
>10%
Somnolence and sedation (16%)
Dizziness (12%)
1-10%
Fatigue (9%)
Nausea and vomiting (5%)
Cerebellar coordination and balance disturbances (3%)
Irritability (3%)
Constipation (2%)
Pregnancy Category Note
Pregnancy
No adequate and well-controlled studies in pregnant women
In animal studies, brivaracetam produced evidence of developmental toxicity at plasma exposures greater than clinical exposure
Lactation
Unknown if distributed in human breast milk
Studies in rats have shown excretion in milk
Because many drugs are excreted into human milk, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Interaction
Doubled effect of alcohol on psychomotor function, attention & memory. Possible increase in plasma conc w/ strong CYP2C19 inhibitors (eg, fluconazole, fluvoxamine). Decreased plasma conc w/ strong enzyme inducers (eg, rifampicin; carbamazepine, phenobarb, phenytoin; St. John's wort). May increase plasma conc of CYP2C19-metabolised products (eg, lansoprazole, omeprazole, diazepam); OAT3-transported medicinal products. May decrease plasma conc of CYP2B6-metabolised products (eg, efavirenz). Increased conc of carbamazepine epoxide.
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