12-24 Hours
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Apidra Cartidge
Synovia Pharma PLC.
Generic: Insulin Glulisine
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Apidra Cartidge.
CONSULT YOUR DOCTOR
Apidra Cartidge may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Apidra Cartidge is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
CAUTION
Apidra Cartidge should be used with caution in patients with kidney disease. Dose adjustment of Apidra Cartidge may be needed. Please consult your doctor.
Regular monitoring of blood glucose levels is recommended for dose adjustment.
CAUTION
Apidra Cartidge should be used with caution in patients with liver disease. Dose adjustment of Apidra Cartidge may be needed. Please consult your doctor.
Frequent and regular monitoring of blood glucose levels is advised.
Medicine Overview of Apidra Cartidge 100IU/ml Injection
Introduction
Apidra Cartidge is used for the treatment of blood sugar control in people with type 1 and type 2 diabetes mellitus. It is a fast-acting type of insulin that helps to lower blood sugar levels after meals and reduce the chances of developing serious complications of diabetes. Apidra Cartidge is normally prescribed along with a long-acting type of insulin or other diabetes medicines. Your doctor or nurse will teach you the correct way of injecting it under the skin. It should be taken 15 minutes before a meal or within 20 minutes after starting a meal. Do not stop...
... Show moreUses of Apidra Cartidge
- Diabetes mellitus (Type 1 & Type 2)
Side effects of Apidra Cartidge
Common
- Hypoglycemia (low blood glucose level)
- Injection site allergic reaction
- Itching
- Rash
- Lipodystrophy (skin thickening or pits at the injection site)
How to use Apidra Cartidge
Your doctor or nurse will guide you how to use this medicine.
How Apidra Cartidge works
Apidra Cartidge is fast-acting insulin which starts working within 10-20 minutes after injecting. It works similar to the insulin produced by the body. Insulin facilitates reuptake of glucose in muscle and fat cells and also blocks the release of glucose from the liver.
What if you forget to take Apidra Cartidge?
If you have missed a dose of Apidra Cartidge, your blood sugar level may become too high (hyperglycemia). Check your blood sugar and then take the next dose accordingly.
Quick Tips
- Take it 15 minutes before a meal or within 20 minutes after starting a meal.
- Injection sites must be rotated to prevent hard lumps from developing at one site.
- Injection below the skin of the abdomen results in faster absorption than other injection sites.
- Do not use it if the preparation is no longer clear and colorless or if it contains particles.
- Hypoglycemia (low blood sugar level) is a common side effect. Monitor your blood sugar level regularly.
- Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremors, weakness, and anxiety.
- Opened vials/cartridges stay good at room temperature for up to 4 weeks, while unopened vials must be placed in the refrigerator (2°C–8°C).
Brief Description
Indication
Diabetes mellitus
Administration
SC injection Administer within 15 minutes before a meal or within 20 minutes after starting a meal When administered by SC injection, insulin glulisine should generally be used in regimens with an intermediate- or long-acting insulin Administered by SC injection in the abdominal wall, thigh, or upper arm Injection sites should be rotated within the same region (abdomen, thigh or upper arm) from one injection to the next to reduce the risk of lipodystrophy IV administration May be administered IV while under medical supervision for glycemic control with close monitoring of blood glucose and serum potassium to avoid hypoglycemia and...
... Show moreAdult Dose
Subcutaneous
Diabetes mellitus
Dose should be individualised and depends on patient's needs. Usual range: 0.5-1 u/kg/day.
Dosing considerations
Equipotent to regular human insulin (ie, elicits same glucose lowering effects on unit per unit basis) when administered IV
Insulin glulisine has a more rapid onset of action and a shorter duration of action than regular human insulin
Dosage must be individualized; blood glucose monitoring is essential in all patients receiving insulin therapy
Insulin requirements may be altered during stress, major illness, or with changes in exercise, meal patterns, or coadministered drugs
Hepatic impairment: Dose reduction may be needed.
Child Dose
Type 1 Diabetes Mellitus
Indicated to improve glycemic control in adults and children with diabetes mellitus
<4 years: Safety and efficacy not established
4-17 years: May require 0.8-1.2 units/kg/day SC during growth spurts; otherwise use adult dosing (0.5-1 unit/kg/day)
Renal Dose
Renal impairment: Dose reduction may be needed.
Contraindication
Hypoglycaemia.Hypersensitivity to any of the components.
Mode of Action
Insulin glulisine is a rapid acting human insulin analog produced by recombinant DNA technology using a non-pathogenic laboratory strain of Escherichia coli (K12). Insulin glulisine and insulin human are equipotent on a unit-for-unit basis. Insulin glulisine has a more rapid onset and shorter duration of action compared with insulin human after subcutaneous admin.
Precaution
Renal or hepatic impairment. Regular monitoring of blood glucose and HbA1c. Rotate Inj sites to reduce lipodystrophy . Pregnancy, lactation.
Lactation: Considered safe during breastfeeding
Side Effect
Hypoglycaemia, Inj site reactions, lipodystrophy, local and systemic hypersensitivity reactions.
Interaction
Possible absence of hypoglycaemic warning symptoms with beta-blockers. Decreased hypoglycaemic effect with corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, phenothiazine derivatives, somatropin, sympathomimetic agents, thyroid hormones, oestrogens, progestins (e.g. in oral contraceptives), protease inhibitors and atypical antipsychotics (e.g. olanzapine and clozapine). Increased hypoglycaemic effect with oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates and sulfonamide antibiotics. Decreased insulin resistance with octreotide and lanreotide. Increased risk of wt gain and peripheral oedema with pioglitazone, rosiglitazone. Decreased effect of sermorelin.
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