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Amipride 50
Beacon Pharmaceuticals PLC
Generic: Amisulpride
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Amipride 50.
CONSULT YOUR DOCTOR
Amipride 50 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Amipride 50 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Amipride 50 may cause side effects which could affect your ability to drive.
You may feel less alert, drowsy or sleepy while taking this medicine. This may affect your driving ability.
CAUTION
Amipride 50 should be used with caution in patients with kidney disease. Dose adjustment of Amipride 50 may be needed. Please consult your doctor.
Use of Amipride 50 is not recommended in patients with severe kidney disease.
SAFE IF PRESCRIBED
Amipride 50 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Amipride 50 may not be needed in these patients. Please consult your doctor.
Medicine Overview of Amipride 50mg Tablet
Introduction
Amipride 50 is a prescription medicine used in the treatment of schizophrenia, a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave. Amipride 50 may be taken with or without food, preferably before bedtime. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. Do not...
... Show moreUses of Amipride 50
- Schizophrenia
Side effects of Amipride 50
Common
- Nausea
- Vomiting
- Dryness in mouth
- Constipation
- Weight gain
- Decreased blood pressure
- Dystonia (involuntary muscle contractions)
- Akathisia (inability to stay still)
- Parkinsonism
- Increased prolactin level in blood
How to use Amipride 50
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Amipride 50 may be taken with or without food, but it is better to take it at a fixed time.
How Amipride 50 works
Amipride 50 is an atypical antipsychotic. It works by modulating the action of certain chemical messengers in the brain that affect thoughts.
Quick Tips
- Amipride 50 helps treat schizophrenia.
- Take it at bedtime to avoid feeling sleepy during the day.
- Use caution while driving or doing anything that requires concentration as Amipride 50 can cause dizziness and sleepiness.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Do not consume alcohol while on treatment with this medicine as it may worsen the side effects.
- It may cause increased weight, blood sugar, cholesterol, and triglycerides (fat) levels. Eat healthy and exercise regularly.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
- Do not stop taking Amipride 50 without talking to your doctor first as it may cause worsening of symptoms.
Brief Description
Indication
Acute and chronic schizophrenic disorders, in which positive symptoms (such as delusions, hallucinations, thought disorders) and/or negative symptoms (such as blunted affect, emotional and social withdrawal) are prominent, including patients characterised by predominant negative symptoms.
Adult Dose
Adult
Acute episodes, 400—800mg daily in two divided doses. Adjust according to response; max 1.2g daily.
Mixed positive and negative symptoms, adjust dose to control positive symptoms.
Predominant negative symptoms, 50—300mg once daily.
Elderly: Dose reduction may be required.
Hepatic Failure: Since the drug is weakly metabolised a dosage reduction should not be necessary.
Child Dose
Under 18 years, not recommended.
Renal Dose
Amisulpride is eliminated by the renal route. In renal insufficiency, the dose should be reduced to half in patients with creatinine clearance (CRCL) between 30-60 ml/min and to a third in patients with CRCL between 10-30 ml/min.
As there is no experience in patients with severe renal impairment (CRCL < 10 ml/min) particular care is recommended in these patients
Contraindication
Prolactin-dependent tumours, phaeochromocytoma. Lactation.
Mode of Action
Amisulpride binds selectively with a high affinity to human dopaminergic D2/D3 receptor subtypes whereas it is devoid of affinity for D1, D4 and D5 receptor subtypes.
Precaution
Cardiovascular disease, family history of QT prolongation, hypokalaemia, renal impairment (CrCl <60ml/min), epilepsy, Parkinson's disease, diabetes, risk factors for stroke or VTE, history or family history of breast cancer. Elderly. Withdraw gradually. Pregnancy; ensure contraception in women.
Lactation
It is not known whether amisulpride is excreted in breast milk, breast-feeding is therefore contra-indicated.
Side Effect
Nervous system disorders: Very common: Extrapyramidal symptoms may occur: tremor, rigidity, hypokinesia, hypersalivation, akathisia, dyskinesia. These symptoms are generally mild at optimal dosages and partially reversible without discontinuation of amisulpride upon administration of antiparkinsonian medication. The incidence of extrapyramidal symptoms which is dose related, remains very low in the treatment of patients with predominantly negative symptoms with doses of 50-300 mg/day. Common: Acute dystonia (spasm torticollis, oculogyric crisis, trismus) may appear. This is reversible without discontinuation of amisulpride upon treatment with an antiparkinsonian agent. Somnolence. Uncommon: Tardive dyskinesia characterized by rhythmic, involuntary movements primarily of the tongue and/or face have...
... Show moreInteraction
Other antipsychotics, drugs that prolong QT interval, levodopa, CNS depressants, alcohol, antihypertensives.
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