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Canaglif 100
Square Pharmaceuticals PLC.
Generic: Canagliflozin
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Canaglif 100.
CONSULT YOUR DOCTOR
Canaglif 100 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Canaglif 100 during breastfeeding is not available. Please consult your doctor.
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
UNSAFE
Canaglif 100 is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
CAUTION
Canaglif 100 should be used with caution in patients with severe liver disease. Dose adjustment of Canaglif 100 may be needed. Please consult your doctor.
Dose adjustment is not needed in patients with mild to moderate liver disease. Limited information is available on use of Canaglif 100 in severe liver disease.
Medicine Overview of Canaglif 100mg Tablet
Introduction
Canaglif 100 is used alone or in combination with other medicines to treat type 2 diabetes mellitus. It helps control the high blood sugar levels seen in diabetes. This reduces the chances of serious complications of diabetes and also helps prevent heart disease. Canaglif 100 can be taken with or without food at any time of day but you should try to take it at the same time every day. The dose will be decided by your doctor. Do not stop taking it without asking your doctor. If you do, your blood sugar levels may increase and put you at...
... Show moreUses of Canaglif 100
- Type 2 diabetes mellitus
Side effects of Canaglif 100
Common
- Frequent urge to urinate
- Urinary tract infection
- Increased thirst
- Nausea
How to use Canaglif 100
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Canaglif 100 is to be taken empty stomach.
How Canaglif 100 works
Canaglif 100 is an anti-diabetic medication. It works by removing excess sugar from your body through urine.
What if you forget to take Canaglif 100?
If you miss a dose of Canaglif 100, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Canaglif 100 is used alone or together with other diabetes medicines to control blood sugar and avoid long-term complications.
- It may cause your body to lose too much fluid (dehydration) or you may urinate more often. Drink plenty of water and stay hydrated.
- It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor and anxiety.
- It can cause genital fungal and/or urinary tract infections (UTIs) in both females and males, so practice good hygiene.
- Monitor your blood sugar regularly while taking this medicine.
- Inform your doctor immediately if you experience constant dizziness, joint pain, cold-like symptoms or unexplained nausea/vomiting.
Brief Description
Indication
Type 2 diabetes mellitus
Adult Dose
Adults >18 years: Recommended Dose: 100 mg PO once daily taken before the first meal of the day
May increase dose to 300 mg once daily in patients tolerating 100 mg/day who have an eGFR >60 mL/min/1.73 m² and require additional glycemic control.
Elderly: In patients >75 years, the starting dose is 100 mg once daily.
Renal Dose
Renal impairment
eGFR >60 mL/min/1.73 m²: No dosage adjustment required
eGFR 45 to <60 mL/min/1.73 m²: Do not exceed 100 mg/day
eGFR <45 mL/min/1.73 m²: Do not initiate canagliflozin
Discontinue if eGFR declines below 45 mL/min/1.73 m²
Contraindication
History of a serious hypersensitivity reaction and hypersensitivity to canagliflozin.
Severe renal impairment (eGFR <30 mL/min/1.73 m2), end stage renal disease or patients on dialysis.
Diabetic Ketoacidosis, Type-1 Diabetes.
Mode of Action
Sodium-glucose co-transporter 2 SGLT-2 inhibition lowers the renal glucose threshold (ie, the plasma glucose concentration which exceed the maximum glucose reabsorption capacity of the kidney); lowering the renal glucose threshold results in increased urinary glucose excretion.
Precaution
Causes intravascular volume contraction and symptomatic hypotension can occur, particularly if eGFR <60 mL/min/1.73 m²2, advance age, existing low systolic BP, or taking either diuretics or drugs that interfere with renin-angiotensin-aldosterone system (RAS) (eg, ACE inhibitors, ARBs). Drug increases serum creatinine and decreases eGFR, patients with hypovolemia are more susceptible to renal function impairment. Hyperkalemia reported; patients with moderate renal impairment who take potassium-sparing diuretics or drugs that alter RAS are more likely to develop hyperkalemia. Hypoglycemia risk increased with insulin and insulin secretagogues, adjust dose. Genital mycotic infections may occur, patients with history of genital mycotic infections and uncircumcised...
... Show moreSide Effect
>10%
Female genital mycotic infections (10.4-11.4%)
1-10%
Increased urination (4.6-5.3%),Male genital mycotic infections (3.7-4.2%),Vulvovaginal pruritus (1.6-3%),Thirst (2.3-2.8%),Constipation (1.8-2.3%),Nausea (2.2-2.3%),Abdominal pain (1.7-1.8%)
Volume depletion
Overall population (2.3-3.4%),Age >75 yr (4.9-8.7%),eGFR <60/mL/min/1.73 m³ (4.7-8.1%),Use of loop diuretic (3.2-8.8%)
Pregnancy Category Note
Pregnancy Based on animal data showing adverse renal effects, not recommended during the second and third trimesters of pregnancy Data are limited in pregnant women and are not sufficient to determine a drug associated risk for major birth defects or miscarriage Clinical considerations Poorly controlled diabetes in pregnancy increases maternal risk for diabetic ketoacidosis, preeclampsia, spontaneous abortions, preterm delivery, stillbirth, and delivery complications Poorly controlled diabetes increases fetal risk for major birth defects, stillbirth, and macrosomia related morbidity Lactation No information regarding distribution in human milk or effects on the breastfed infant or milk production Present in milk of lactating...
... Show moreInteraction
Decreased efficacy w/ rifampicin. Increase AUC & Cmax of digoxin (not clinically meaningful).
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