Introduction
Caprolex is used to treat bleeding. It helps to prevent bleeding after major heart surgery and it also controls bleeding in thrombocytopenia (accompanying aplastic anemia), liver cirrhosis, urinary bleeding and some types of cancer.
Caprolex works by preventing the breakdown of clots which leads to stoppage of bleeding. This injection must be administered under the supervision of a healthcare professional. You should not take it if you have any known allergy from this injection.
The most common side effects may be injection site reactions such as pain, swelling and redness or pain in the muscle, bone or joint. Inform your doctor if you have undergone any cardiac surgery or you are suffering from any liver disease.
This injection is safe to use in pregnant or breastfeeding mothers. It is also safe to use in patients suffering from kidney diseases. Caution is advised to drive after the administration of this injection.
Side effects of Caprolex
Common
- Nasal congestion (stuffy nose)
- Tiredness
- Musculoskeletal (bone, muscle or joint) pain
- Injection site reactions (pain, swelling, redness)
How to use Caprolex
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Caprolex works
Caprolex prevents the breakdown of clots and stops bleeding.
What if you forget to take Caprolex?
If you miss a dose of Caprolex, skip it and continue with your normal schedule. Do not double the dose.
Indication
Intravenous
Treatment and prophylaxis of haemorrhage
Adult: Initially, 4-5 g as a 2% solution over 1 hr followed by a 1 g/hr infusion continued for up to 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr.
Oral
Treatment and prophylaxis of haemorrhage
Adult: Initially, 4-5 g, followed by 1-1.25 g every hr for about 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr.
Patients with haemophilia undergoing dental extraction
Adult: Initially, 6 g immediately after the procedure, followed by 6 g every 6 hr for up to 10 days.
Administration
Increased risk of hypercoagulability with OC and oestrogens.
Adult Dose
Renal or cardiac disorders. Urinary tract bleeding, haematuria of upper urinary tract origin; veno-occlusive hepatic disease, skeletal myopathy, neonates. Monitor creatinine phosphokinase. Avoid admin with factor IX complex concentrates. Pregnancy and lactation.
Lactation: not known whether excreted in breast milk, use caution
Renal Dose
Aminocaproic acid inhibits the action of plasminogen activators and, to a lesser extent, it also has some antiplasmin activity.
Mode of Action
IV Administration
Initial 5 g in 250 mL over 1 hr, each subsequent gram in 50-100 mL at 1 g/hr
Rapid injection undiluted into a vein is not recommended
Continue for about 8 hr or until bleeding has been controlled
Oral
May be taken with or without food. May be taken w/ meals to prevent GI upset.
Precaution
Haemorrhage, Missed abortion, Hereditary hemorrhagic telangiectasia,Traumatic hyphema, Dental bleeding, Hemophilia A, Postoperative bleeding, Systemic hyperfibrinolysis
Side Effect
Renal impairment: Dosage reduction may be required.
Pregnancy Category Note
Oedema, headache, malaise, allergic and anaphylactic reactions, anaphylaxis, bradycardia, hypotension, peripheral ischaemia, thrombosis, abdominal pain, diarrhoea, nausea, vomiting, agranulocytosis, coagulation disorder, leukopaenia, thrombocytopaenia, increased CPK, muscle damage, myalgia, myopathy, myositis, rhabdomyolysis, confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope, dyspnoea, nasal congestion, pulmonary embolism, pruritus, rash, tinnitus, decreased vision, watery eyes, increased BUN, dry ejaculation.
Potentially Fatal: Cardiac and hepatic damage.
Interaction
Bleeding due to disseminated intravascular coagulation. Rapid IV administration.