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Dynase
Beximco Pharmaceuticals Ltd.
Generic: Azelastine + Fluticasone Propionate Nasal prep
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
Dynase may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Dynase is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Medicine Overview of Dynase 137mcg+50mcg/Spray Nasal Spray
Introduction
Dynase is a combination medicine used in the treatment of allergy symptoms such as runny nose, stuffy nose, sneezing, watery eyes and congestion or stuffiness. Dynase should be used as you have been advised by your doctor. Do not use it more often or for longer than recommended. Normally you should blow your nose gently before using it, keep one nostril closed while applying the medicine into the other and then sniff hard to make sure it reaches deep into the nose. Then repeat for the other nostril. It provides relief very quickly and can last for several hours. If...
... Show moreUses of Dynase
- Sneezing and runny nose due to allergies
Side effects of Dynase
Common
- Taste change
- Headache
- Nosebleeds
How to use Dynase
Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Insert the bottle tip into one nostril and close the other nostril. Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose. As you spray, breath gently and keep the head upright. Repeat the same process for the other nostrils.
How Dynase works
Dynase is a combination of two medicines: Fluticasone Propionate and Azelastine, which relieves sneezing and runny nose caused due to allergies (allergic rhinitis). Fluticasone Propionate is a steroid which works by blocking the release of certain chemical messengers that cause inflammation (swelling) and irritation in the nose. Azelastine is an antiallergic which relieves allergy symptoms like runny nose, watery eyes and sneezing.
Quick Tips
- The right way to use the nasal spray:
- Avoid deep breathing as it will cause medication to go back to the throat and make it less effective.
- Inform your doctor if you have an infection,injury or ulceration in the inside of the nose as Dynase can increase the risk of nose bleed and ulceration.
- Do not share the bottle with anyone else so that you do not spread germs.
Brief Description
Indication
Seasonal Allergic Rhinitis
Administration
Shake bottle gently prior to each use
Prime the bottle before initial use by releasing 6 sprays or more until a fine mist sprays
Reprime the bottle if unused for >14 days by spraying once or more until fine mist appears
Adult Dose
Nasal Spray
Seasonal allergic rhinitis
The recommended dosage is 1 spray each nostril twice daily.
Child Dose
Nasal Spray
Seasonal Allergic Rhinitis
6 years: 1 each nostril twice daily.
Contraindication
There is no known contraindication.
Mode of Action
Azelastine: Phthalazinones derivative; elicits histamine H1-receptor antagonist activity; major metabolite (desmethylazelastine) also exhibits histamine H1-receptor antagonist activity
Fluticasone: Corticosteroid possessing anti-inflammatory activity; exact mechanism of action unknown, but shown to exhibit anti-inflammatory effect on multiple cells (eg, neutrophils, eosinophils, macrophages, mast cells, lymphocytes) and mediators (eg, histamine, leukotrienes, cytokines and eicosanoids)
Precaution
Avoid spraying directly into eyes; if drug is sprayed into eyes, flush with water for a minimum of 10 minutes May cause somnolence; avoid operating heavy machinery or engaging in tasks that require mental alertness and coordination Do not use with history of recent nasal ulcers, nasal surgery, or any nasal trauma May cause glaucoma or cataracts As corticosteroids may cause immunosuppression, patients should notify healthcare providers if they experience any symptoms of tuberculosis, viral, bacterial, fungal or parasitic infections or ocular herpes simplex Due to the potential reduction in growth velocity in children, patients must be monitored routinely Lactation:...
... Show moreSide Effect
1-10%
Dysgeusia (4%),Headache (2%),Epistaxis (2%)
Frequency Not Defined
Somnolence,Nasal effects (eg, nasal ulceration, nasal septal perforation),Impaired wound healing,Candida albicans infection,Glaucoma,Cataracts,Immunosuppression,Hypothalamic-pituitary-adrenal (HPA) axis suppression
Pregnancy Category Note
Pregnancy Limited data from postmarketing experience over decades of use in pregnant women have not identified any drug associated risks of miscarriage, birth defects, or other adverse maternal or fetal outcomes Animal data Animal reproduction studies with combination product are not available; however, studies are available with its individual components, azelastine hydrochloride and fluticasone propionate In animal reproduction studies with azelastine, there was no evidence of fetal harm at oral doses approximately 5 times the clinical daily dose; oral administration to pregnant mice, rats, and rabbits, during the period of organogenesis, produced developmental toxicity that included structural abnormalities, decreased embryo-fetal...
... Show moreInteraction
Additive effects with CNS depressants and ethanol. Increased plasma concentration w/ potent CYP3A4 inhibitors (e.g. ritonavir).
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