12-24 Hours
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Cartilex D
ACI Limited
Generic: Diacerein + Glucosamine Sulphate
Medicine Overview of Cartilex D 50mg+750mg Tablet
বাংলা
English
Indication
Rheumatoid arthritis, Osteoarthritis, Chronic low back pain
Administration
Should be taken with food. Take w/ or immediately after meals.
Adult Dose
Oral
Osteoarthritis
Adults:
1 tablet twice daily
Child Dose
Oral
Osteoarthritis
Children over 12 years and older:
1 tablet twice daily
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<30 25 mg daily.
Contraindication
Absorption of Diacerein is reduced if taken with aluminium and/or magnesium hydroxide antacid. Diacerein also increases risk of diarrhea if taken with laxatives, antibiotics. Avoid co-administration with fibers and phytic acids. Diacerein has shown hypersensitivity to anthraquinone derivatives.
Mode of Action
Diacerein is an anthraquinone derivative that has been used in osteoarthritis. It is thought to act via inhibition of interleukin-1. Glucosamine stimulates the production of proteoglycans and increases sulfate uptake by articular cartilage.
Precaution
Caution should be practiced when administering Diacerein + Glucosamine Sulphate in those patients who are allergic to Glucosamine and/or Diacerein or to shellfish (e.g., shrimp, crab); who have diabetes, asthma, alcohol dependence or liver disease. Before taking Diacerein + Glucosamine Sulphate complete blood count, liver function and urinalysis should be monitored regularly.
Side Effect
Diarrhea, constipation, epigastric pain, heart burn, nausea, vomiting, headache, skin rashes, drowsiness, intense yellow coloring of urine.
Interaction
Diacerein: Decreased absorption with aluminium and/or magnesium hydroxide antacids. Increased risk of diarrhoea with laxatives, antibiotics. Avoid co-admin with fibres and phytates.
Glucosamine: May reduce effect of antidiabetic agents, doxorubicin, etoposide, tenoposide. May enhance anticoagulant activity of warfarin.
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