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Presart AM 5/40
General Pharmaceuticals Ltd.
Generic: Telmisartan + Amlodipine
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Presart AM 5/40.
CONSULT YOUR DOCTOR
Presart AM 5/40 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Presart AM 5/40 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Presart AM 5/40 may cause side effects which could affect your ability to drive.
It may cause dizziness, headaches, nausea or tiredness, all of which could affect your ability to concentrate and drive.
SAFE IF PRESCRIBED
Presart AM 5/40 is safe to use in patients with kidney disease. No dose adjustment of Presart AM 5/40 is recommended.
CAUTION
Presart AM 5/40 should be used with caution in patients with liver disease. Dose adjustment of Presart AM 5/40 may be needed. Please consult your doctor.
Medicine Overview of Presart AM 5/40 5mg+40mg Tablet
Introduction
Presart AM 5/40 contains two medicines, both of which help to control high blood pressure. It lowers the blood pressure by relaxing the blood vessels and making it easier for your heart to pump blood around your body. This will reduce your risk of having a heart attack or a stroke. Presart AM 5/40 may be taken on an empty stomach or along with food. However, it is better to take it regularly at a fixed time each day, as prescribed by your doctor. The dose will depend on your condition and how you respond to the medicine. It's important...
... Show moreUses of Presart AM 5/40
- Hypertension (high blood pressure)
Side effects of Presart AM 5/40
Common
- Sleepiness
- Ankle swelling
- Headache
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Dizziness
- Tiredness
- Palpitations
- Upset stomach
- Increased potassium level in blood
How to use Presart AM 5/40
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Presart AM 5/40 may be taken with or without food, but it is better to take it at a fixed time.
How Presart AM 5/40 works
Presart AM 5/40 is a combination of two medicines: Telmisartan and Amlodipine. Telmisartan is an angiotensin receptor blocker (ARB) and Amlodipine is a calcium channel blocker (CCB). They work by relaxing the blood vessels and making the heart more efficient at pumping blood throughout the body. Together, they lower blood pressure effectively.
Quick Tips
- Presart AM 5/40 is a combination of two medicines that provides better blood pressure control than either medicine alone.
- Presart AM 5/40 may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- It may cause you to feel lightheaded or weak especially when you stand up. Rise slowly if you have been sitting or lying down.
- Avoid consuming alcohol as it may enhance the blood pressure lowering effect of this medicine.
- It can cause ankle or foot swelling. Raise your legs while you are sitting down and talk to your doctor if it does not go away.
- Do not take Presart AM 5/40 if you are pregnant, planning to conceive or breastfeeding.
Brief Description
Indication
Hypertension Initial Therapy: Patient may be initiated on Telmisartan/Amlodipine tablets if it is unlikely that control of blood pressure would be achieved with a single agent. The usual starting dose is 40/5 mg once daily. Patients requiring larger blood pressure reductions may be started with 80/5 mg once daily. OR Substitute for individually titrated components May increase dose after at least 2 weeks, not to exceed 80 mg/10 mg qDay Dosage range: Telmisartan 20-80 mg/amlodipine 2.5-10 mg PO qDay Initial therapy with Telmisartan/Amlodipine is not recommended in patients ?75 years old or with hepatic impairment. Hepatic Impairment Severe impairment: Titrate...
... Show moreAdministration
Amlodipine relaxes peripheral and coronary vascular smooth muscle. It produces coronary vasodilation by inhibiting the entry of Ca ions into the slow channels or select voltage-sensitive channels of the vascular smooth muscle and myocardium during depolarisation. It also increases myocardial oxygen delivery in patients w/ vasospastic angina.
Adult Dose
May increase frequency and/or severity of angina during treatment initiation or dosage increments.
Heart failure or hepatic impairment.
Avoid fetal or neonatal exposure
Hypotension: Correct any volume or salt depletion before initiating therapy. Observe for signs and symptoms of hypotension.
Titrate slowly in patients with hepatic or severe renal impairment
Heart failure: Monitor for worsening
Avoid concomitant use of an ACE inhibitor and angiotensin receptor blocker
Myocardial infarction: Uncommonly, initiating a CCB in patients with severe obstructive coronary artery disease may precipitate myocardial infarction or increased angina
Lactation: Discontinue drug or do not breast feed
Child Dose
Pregnancy Category: C (1st trimester); D (2nd & 3rd trimesters)
Renal Dose
Telmisartan, a non-peptide angiotensin receptor blocker (ARB), is specific angiotensin II antagonist acting on the AT1 subtype. Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium, which leads to an increase in blood pressure (hypertension). Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Therefore, Telmisartan dilates blood vessels and reduces blood pressure without...
... Show moreMode of Action
May be taken with or without food.
Precaution
Treatment of hypertension, alone or with other anti-hypertensive agents. It may also be used as initial therapy in patients who are likely to need multiple drugs to achieve their blood pressure goals.
Side Effect
Mild to moderate impairment: Dose adjustment not recommended
Pregnancy Category Note
>10%
Peripheral edema (1-11%)
1-10%
Dizziness (3%),Orthostatic hypotension (6%),Syncope (2%),Back pain (2%)
Interaction
Known hypersensitivity to this product or any of its components. Pregnancy & lactation. Biliary obstructive disorders, severe hepatic impairment, hypotension, cardiogenic shock, left ventricle outflow tract obstruction.
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