Polyvalent cations
Baloxavir (active metabolite) may form a chelate with polyvalent cations, such as calcium, aluminum, or magnesium, in food or medications
Avoid coadministration with dairy products, calcium-fortified beverages, polyvalent cation-containing laxatives, antacids, or oral supplements (eg, calcium, iron, magnesium, selenium, zinc)
Vaccines
Concurrent use with intranasal live attenuated influenza vaccine (LAIV) not evaluated
Coadministration may inhibit viral replication of LAIV, resulting in decreased LAIV vaccine effectiveness