Out of stock
ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
Register
Medicine Overview of Temixil 10mg Tablet
বাংলা
English
Indication
Insomnia, Premedication in surgery
Administration
May be taken with or without food. Gradually taper after extended therapy; abrupt discontinuation should be avoided
Adult Dose
Oral
Short-term management of insomnia
Adult: 7.5-30 mg at bedtime for 7-10 days. Max: 40 mg.
Elderly: 5 mg at bedtime. May be increased to 10-20 mg in severe cases.
Hepatic impairment: 5 mg at bedtime. May be increased to 10-20 mg in severe cases.
Severe: Contraindicated.
Premedication in surgery
Adult: 20-40 mg, 30 min to 1 hr before the procedure.
Elderly: 10-20 mg, 1 hr before the procedure.
Hepatic impairment: Severe: Contraindicated.
Child Dose
Safety and efficacy not established
Renal Dose
Insomnia
Renal impairment: 5 mg at bedtime. May be increased to 10-20 mg in severe cases.
Contraindication
Acute pulmonary insufficiency, resp depression, sleep apnoea, obsessional states, myasthenia gravis, severe hepatic impairment. Pregnancy.
Mode of Action
Temazepam is a short-acting benzodiazepine w/ anxiolytic, hypnotic/sedative, muscle relaxant properties. It increases neuronal membrane permeability to Cl ions by binding to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS and enhancing the GABA inhibitory effects resulting in hyperpolarisation and stabilisation.
Precaution
Patient w/ severe depression, chronic pulmonary insufficiency, personality disorders, history of alcohol or drug addiction. Avoid abrupt withdrawal. Renal and hepatic impairment. Elderly or debilitated patient. Lactation. Patient Counselling May impair ability to perform tasks that require alertness (e.g. driving or operating machinery). Monitoring Parameters Monitor resp and CV status.
Lactation: Avoid if breastfeeding
Side Effect
1-10%
Drowsiness (9.1%),Dizziness (4.5%),Lethargy (4.5%),Hangover (2.5%),Diarrhea (1.7%),Euphoria (1.5%),Weakness (1.4%),Confusion (1.3%),Vertigo (1.2%)
< 1%
Amnesia,Angioedema,Blood dyscrasias,Sleep-related behavior (eg, sleep driving, sleep cooking, sleep eating),Ataxia
Interaction
May enhance CNS depressant effect w/ Na oxybate, antipsychotics, tranquilisers, neuroleptics, antidepressants, hypnotics, anaesth, analgesics, sedative antihistamines, barbiturates. Effect may be reduced w/ theophylline.
ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
Register