Introduction
Cefaking is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the lungs (eg. pneumonia), ear, urinary tract, skin and soft tissues, bones and joints, blood, and heart. It is also used to prevent infections during surgery.
Cefaking fights and stops the growth of many types of bacteria. This helps to improve your symptoms and cure the underlying infection. It is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare professional. Your doctor will decide the correct dose for you. You should use this medicine regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening.
The most common side effects of this medicine include diarrhea and changes in liver function tests and blood counts. Some people may develop temporary redness or pain at the site of injection. These side effects are usually mild but let your doctor know if they bother you or last more than a few days. Avoid consuming alcohol while taking this medicine as it may cause increased side effects.
Before using it, you should tell your doctor if you are allergic to any antibiotics, and if you have any liver or kidney problems. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine. Pregnant and breastfeeding mothers should consult their doctor before using it.
Side effects of Cefaking
Common
- Increased liver enzymes
- Allergic reaction
- Anemia (low number of red blood cells)
- Diarrhea
How to use Cefaking
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Cefaking works
Cefaking is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Cefaking?
If you miss a dose of Cefaking, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Indication
Respiratory Tract Infections, Peritonitis and Other Intra-abdominal Infections, Bacterial Septicemia, Infections of the Skin and Skin Structures, Pelvic Inflammatory Disease, Endometritis, and Other Infections of the Female Genital Tract, Urinary Tract Infections
Adult Dose
Parenteral
Susceptible infections
Adult: As sodium: 2-4 g daily in 2 divided doses, increased to 12 g daily in 2-4 divided doses for severe infections given as deep IM or IV infusion.
Hepatic impairment: Max for hepatic impairment or biliary obstruction: 4 g daily. W/ renal impairment: 1-2 g daily.
Renal Dose
Renal impairment: W/ hepatic impairment: 1-2 g daily.
Contraindication
Hypersensitivity to cephalosporin.
Mode of Action
Cefoperazone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Precaution
History of penicillin allergy; renal or hepatic impairment; pregnancy, lactation; cystic fibrosis.
Side Effect
Skin rash, urticaria; eosinophilia, diarrhoea, nausea, vomiting; phloebitis; hypoprothrombinaemia; superinfection.
Potentially Fatal: Neuromuscular hypersensitivity; nephrotoxicity.
Interaction
Disulfiram-like reaction with alcohol. Potentiates anticoagulants.
Potentially Fatal: Enhances nephrotoxicity by aminoglycosides and furosemide.