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Mariprist
Renata Limited
Generic: Mifepristone + Misoprostol
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Mariprist.
UNSAFE
Mariprist is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
UNSAFE
Mariprist is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Mariprist may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CONSULT YOUR DOCTOR
There is limited information available on the use of Mariprist in patients with kidney disease. Please consult your doctor.
SAFE IF PRESCRIBED
Mariprist is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Mariprist may not be needed in these patients. Please consult your doctor.
Medicine Overview of Mariprist 200mg+200mcg Tablet
Introduction
Mariprist is a combination of two medicines, which is used for medical abortion (terminating a pregnancy). This medicine blocks the action of progesterone, a female hormone required to maintain pregnancy and induce contractions in the uterus, which further helps in abortion. Mariprist should be taken with food or as your doctor's advice. You must start with dose of Mifepristone. It should be taken orally, by swallow the tablets whole with a drink of water. If you experience vomiting within 30 minutes of tablet intake, inform your doctor or take another tablet. The medicine may take 24- 48 hours to show...
... Show moreUses of Mariprist
- Medical abortion
Side effects of Mariprist
Common
- Nausea
- Vomiting
- Diarrhea
- Stomach cramp
- Uterine contractions
- Menorrhagia (heavy menstrual bleeding)
How to use Mariprist
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Mariprist is to be taken with food.
How Mariprist works
Mariprist is a combination of two medicines: Mifepristone and Misoprostol, which causes abortion. Mifepristone blocks the effects of progesterone, a natural female hormone which is needed for the pregnancy to sustain. Without this hormone, the lining of the uterus (womb) breaks down as it does during a menstrual period and stops the growth of the pregnancy. Mifepristone increases contractions of the uterus to cause abortion.
Quick Tips
- Mariprist helps terminate a pregnancy.
- Use caution while driving or doing anything that requires concentration as it can cause dizziness and sleepiness.
- It does not affect fertility. Use contraception to avoid pregnancy.
- For pregnancy termination:
Brief Description
Indication
Termination of pregnancy upto 9th week(63 days) of gestation, Early menstrual regulation.
Adult Dose
Day 1 (First visit): Mifepristone administration Day 1 One tablet of Mifepristone (200 mg) is taken in a single oral dose under the supervision of a qualified medical professional in a clinic, medical office or hospital. Day 2 (second visit): Misoprostol administration 24-48 hours after ingesting of Mifepristone tablet, the patient takes 4 tablets of 200 microgram (800 micrograms) of Misoprostol buccally. Misoprostol tablets can be administered by the patient herself (place two tablets on each side of cheek & gum). She should wait for 30 minutes. During the period immediately following the administration of Misoprostol, the patients may need...
... Show moreContraindication
Confirmed or suspected ectopic pregnancy, chronic adrenal failure, concurrent long-term corticosteroid therapy, history of allergy to mifepristone, misoprostol or other prostaglandin, haemorrhagic disorders or concurrent anticoagulant therapy, porphyria, hepatic or renal impairment; pregnancy and lactation; IUD in place; undiagnosed adnexal mass.
Mode of Action
Mifepristone is a progesterone antagonist with antiglucocorticoid activity. It binds to the intracellular progesterone receptor where it competitively inhibits progesterone attachment. It is also a partial progesterone agonist.
Misoprostol, a synthetic prostaglandin E1 analogue, exerts its antisecretory activity by directly acting on specific prostaglandin receptors found on the surface of gastric parietal cells. It exerts its protective effects on the mucosa by replacing the prostaglandins consumed during prostaglandin-inhibiting therapies e.g. NSAIDs.
Precaution
Mifepristone + Misoprostol must not be administered if there is doubt as to the existence or age of the pregnancy or if an extra-uterine pregnancy is suspected. An ultrasound scan and/or measurement of Beta-hCG must be performed before administration. For first trimester abortions, Mifepristone is contraindicated if the pregnancy is beyond 49 days of amenorrhoea when used with Misoprostol. Mifepristone + Misoprostol should never be prescribed in patients with chronic adrenal failure, known allergy to Mifepristone or to any component of the product, severe asthma uncontrolled by corticosteroid therapy, porphyrias and renal failure, liver failure or malnutrition, or during breast...
... Show moreSide Effect
Mifepristone: The treatment is designed to induce the vaginal bleeding and uterine cramping necessary for menstrual Regulation (MR). Commonly reported side effects were nausea, vomiting and diarrhea, pelvic pain, fainting, headache, dizziness and asthenia occurred rarely.
Misoprostol: Gastro-intestinal side effects like diarrhea, abdominal pain, nausea, flatulence, dyspepsia, headache, vomiting and constipation, shivering, hyperthermia, dizziness, pain due to uterine contractions, severe vaginal bleeding, shock, pelvic pain, uterine rupture (requiring surgical repair, hysterectomy and/or salpingo-oophorectomy).
Interaction
Decreased efficacy with aspirin and NSAIDs. Efficacy of corticosteroids (including inhaled) decreased, monitor patients during co-admin and for several days afterwards.
May increase effects of oxytocin. Increased risk of misoprostol-induced diarrhoea with magnesium-containing antacids.
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