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Vorifast
Healthcare Pharmaceuticals Ltd.
Generic: Voriconazole
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Vorifast.
CONSULT YOUR DOCTOR
Vorifast is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Vorifast is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Vorifast may cause side effects which could affect your ability to drive.
Vorifast may cause blurring of vision or uncomfortable sensitivity to light and this may impair your ability to drive.
SAFE IF PRESCRIBED
Vorifast is safe to use in patients with kidney disease. No dose adjustment of Vorifast is recommended.
CAUTION
Vorifast should be used with caution in patients with liver disease. Dose adjustment of Vorifast may be needed. Please consult your doctor.
Regular monitoring of liver function tests is advised while you are taking this medicine.
Medicine Overview of Vorifast 200mg Injection
Introduction
Vorifast belongs to a group of medicines called antifungals. It works by stopping the growth of fungus and is used to treat a wide range of fungal infection. It kills fungi by destroying the fungal cell membrane. Vorifast should be taken in the dose and duration as prescribed by your doctor. It should be swallowed whole. It should be taken one hour before or one hour after a meal. The dosage and length of treatment will depend on the condition you are being treated for. Sometimes this will be in cycles of use and non-use. To get the most benefit,...
... Show moreUses of Vorifast
- Severe fungal infections
Side effects of Vorifast
Common
- Abnormal liver function tests
- Hallucination
- Slow heart rate
- Altered vision
- Headache
- Nausea
- Rash
- Vomiting
How to use Vorifast
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Vorifast is to be taken empty stomach.
How Vorifast works
Vorifast is an antifungal medication. It kills and stops the growth of the fungi by destroying its cell membrane, thereby treating your skin infection.
Quick Tips
- Your doctor has prescribed Vorifast to cure your infection and improve symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better.
- It should be taken one hour before or one hour after a meal.
- Do not take indigestion remedies (antacids) within two hours of taking Vorifast.
- Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Candidemia, Deep tissue Candida infections, Invasive aspergillosis, Scedosporiosis and Fusariosis
Administration
Should be taken on an empty stomach. Take at least 1 hr before or after meals.
Infuse IV over 1-2 hr, not to exceed 3 mg/kg/hr
Adult Dose
Adult
Invasive Aspergillosis, Candidemia, Serious Fungal Infections
6 mg/kg IV q12hr for first 24 hours, then 4 mg/kg IV q12hr
or 200 mg PO q12hr
Esophageal Candidiasis
Candida albicans, Candida glabrata, Candida krusei
200 mg PO q12hr
Hepatic impairment: Mild to moderate (Child-Pugh category A and B): Standard loading dose but maintenance doses should be reduced by 50%.
Child Dose
12 years
Invasive Aspergillosis, Candidemia, Serious Fungal Infections
6 mg/kg IV q12hr for first 24 hours, then 4 mg/kg IV q12hr
or 200 mg PO q12hr
Esophageal Candidiasis
Candida albicans, Candida glabrata, Candida krusei
200 mg PO q12hr
Contraindication
Hypersensitivity. Co-admin w/ CYP3A4 substrates, terfenadine, astemizole, cisapride, pimozide, quinidine, rifampicin, carbamazepine, long-acting barbiturates (e.g. phenobarbital, mephobarbital), ergot alkaloids (e.g. ergotamine and dihydroergotamine), efavirenz (≥400 mg once daily), ritonavir (≥400 mg bid), sirolimus, rifabutin, St John's wort.
Mode of Action
Voriconazole is a triazole antifungal agent which inhibits cytochrome P450-dependent enzymes thereby inhibiting ergosterol synthesis in fungal cell membranes. It has a broad spectrum of activity against all Candida spp. including strains resistant to fluconazole), Aspergillus spp., Scedosporium spp., and Fusarium spp.
Precaution
Patient w/ potentially proarrhythmic conditions, risk for acute pancreatitis. Correct electrolyte disturbances e.g. hypokalaemia, hypomagnesaemia and hypocalcaemia prior to treatment. Hepatic and renal impairment. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Avoid intense or prolonged exposure to direct sunlight. Monitoring Parameters Monitor hepatic (prior and during treatment) and renal (during treatment) function, serum electrolytes, visual and pancreatic function.
Lactation: Not known if excreted in breast milk, a decision should be made whether to discontinue nursing or drug; weigh risk/benefit
Side Effect
>10%
Visual changes (photophobia, color changes, increased or decreased visual acuity, or blurred vision occur in 21%)
1-10%
Tachycardia,Hypertension,Hypotension,Vasodilation,Peripheral edema,Fever,Chills,Headache,Hallucinations,Dizziness,Rash,Pruritus,Photosensitizing skin reactions,Hypokalemia,Hypomagnesemia,Nausea,Vomiting,Abdominal pain,Diarrhea,Xerostomia,Thrombocytopenia,Alkaline phosphatase increased,Serum transaminases increased, ALT/AST increased,Cholestatic jaundice,ARF
Interaction
Increased prothrombin time w/ oral anticoagulants. May increase plasma concentrations of ciclosporin and tacrolimus, long-acting opiates (e.g. oxycodone, methadone), NSAIDs (e.g. ibuprofen, diclofenac), omeprazole, short-acting opiates (e.g. alfentanil, fentanyl). Decreased voriconazole plasma concentration and increased phenytoin plasma concentrations when used concomitantly. May increase plasma concentration w/ oral contraceptives. Potentially Fatal: May increase risk of QT prolongation or torsades de pointes w/ astemizole, cisapride, pimozide, quinidine and terfenadine. May increase risk of ergotism w/ ergot alkaloids (e.g. ergotamine and dihydroergotamine). May significantly increase plasma concentrations of sirolimus. Decreased plasma concentrations w/ rifampicin, carbamazepine, long-acting barbiturates (e.g. phenobarbital, mephobarbital), efavirenz (?400 mg...
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