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Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Nebiren 5. Please consult your doctor.
CONSULT YOUR DOCTOR
Nebiren 5 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Nebiren 5 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Nebiren 5 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Nebiren 5 should be used with caution in patients with severe kidney disease. Dose adjustment of Nebiren 5 may be needed. Please consult your doctor.
CAUTION
Nebiren 5 should be used with caution in patients with liver disease. Dose adjustment of Nebiren 5 may be needed. Please consult your doctor.
Use of Nebiren 5 is not recommended in patients with severe liver disease.
Medicine Overview of Nebiren 5mg Tablet
Introduction
Nebiren 5 belongs to a group of medicines called beta-blockers. It is used to treat high blood pressure (hypertension), and heart failure. It also helps to prevent future heart attacks and stroke and to prevent migraine. Nebiren 5 is also used to relieve the symptoms caused by an overactive thyroid gland. It may be prescribed alone or together with other medications. The dose and frequency depend on what you are taking it for and the severity of your condition. It may be taken empty stomach or with a meal, but take it regularly at the same time each day to...
... Show moreUses of Nebiren 5
- Hypertension (high blood pressure)
Side effects of Nebiren 5
Common
- Nausea
- Headache
- Fatigue
- Constipation
- Diarrhea
- Dizziness
- Cold extremities
How to use Nebiren 5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nebiren 5 may be taken with or without food, but it is better to take it at a fixed time.
How Nebiren 5 works
Nebiren 5 is a beta blocker that works specifically on the heart. It works by slowing down the heart rate and makes the heart more efficient at pumping blood around the body.
Quick Tips
- Nebiren 5 lowers your blood pressure and makes it easier for your heart to pump blood around your body.
- Lowering high blood pressure helps prevent stroke and heart attack.
- It may cause dizziness. If this happens to you, get up slowly when rising from a sitting or lying position.
- It can hide symptoms of low blood sugar if you are diabetic. Monitor your blood sugar levels regularly.
- Do not stop taking Nebiren 5 suddenly as it can cause your blood pressure to rise suddenly, thereby increasing the risk of heart attack and stroke.
Brief Description
Indication
Heart failure, Hypertension
Administration
May be taken with or without food.
Adult Dose
Oral
Hypertension
Adult: Initially, 5 mg once daily. May increase dose at intervals of 2 wk if needed. Max: 40 mg once daily.
Elderly: >65 yr Initially, 2.5 mg once daily increased to 5 mg once daily if required.
Oral
Heart failure
Adult: Initially, 1.25 mg once daily. May double dose every 1-2 wk if tolerated. Max: 10 mg once daily.
Hepatic impairment
2.5 mg/day PO initially; increased cautiously
Renal Dose
Renal impairment: CrCl <30 mL/min: Initially, 2.5 mg once daily. Maintenance: Increased to 5 mg once daily if required.
Contraindication
Hepatic impairment, sick sinus syndrome, 2nd and 3rd degree heart block (without a pacemaker), history of asthma, metabolic acidosis, severe peripheral arterial disease, severe bradycardia, cardiogenic shock or decompensated heart failure, untreated phaeochromocytoma. Pregnancy and lactation.
Mode of Action
Nebivolol exhibits high selectivity for beta1-adrenergic receptors and has vasodilating activity due to a direct action on the endothelium, involving nitric oxide release. It lacks intrinsic sympathomimetic and membrane-stabilising activity.
Precaution
Patients w/ inadequate cardiac function, well-compensated heart failure, myasthenia gravis. Patients undergoing major surgery involving general anaesth. May mask signs and symptoms of hypoglycaemia and hyperthyroidism. Abrupt withdrawal may exacerbate angina symptoms and/or precipitate MI and ventricular arrhythmias in patients w/ coronary artery disease. Pregnancy and lactation. Monitoring Parameters Monitor ECG, BP and blood glucose in diabetic patients.
Lactation: Not known whether drug is excreted into breast milk; use not recommended
Side Effect
1-10%
Headache (6-9%),Fatigue (2-5%),Dizziness (2-4%),Diarrhea (2-3%),Nausea (1-3%),Increased triglyceride levels and insulin resistance, decreased high-density lipoprotein (HDL) levels (1%),Insomnia (1%),Peripheral edema (1%),Weakness (1%)
<1%
Bradycardia.Chest pain,Dyspnea
Potentially Fatal: Anaphylaxis.
Interaction
Increased plasma concentrations w/ potent CYP2D6 inhibitors (e.g. paroxetine, fluoxetine, propafenone, thioridazine, quinidine). Concomitant use w/ antiarrhythmic drugs (e.g. amiodarone, disopyramide) or nondihydropyridine Ca channel blockers (e.g. diltiazem, verapamil) may cause conduction disturbance. Additive negative effects on AV conduction and heart rate w/ other beta-adrenergic blocking agents or digoxin. Concurrent admin w/ catecholamine-depleting agents (e.g. reserpine) may result in additive hypotension or bradycardia. Abrupt withdrawal of clonidine may increase risk of rebound HTN.
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