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Mavixen
Everest Pharmaceuticals Ltd.
Generic: Glecaprevir + Pibrentasvir
Medicine Overview of Mavixen 100mg+40mg Tablet
বাংলা
English
Indication
Chronic Hepatitis C
Administration
Take with food at the same time once daily
Adult Dose
Chronic Hepatitis C Treatment-naïve adults and adolesents with chronic hepatitis C virus (HCV) genotypes 1-6 without cirrhosis or with compensated cirrhosis Treatment-experienced patients with HCV genotype 1 who have been previously treated with a regimen containing either an NS5A inhibitor or an NS3/4A protease inhibitor, but not both 3 tablets (ie, 300 mg/120 mg total dose) PO once daily with food Recommended duration for treatment-naïve patients Genotypes 1-6, no cirrhosis: 8 wk Genotypes 1-6, compensated cirrhosis (Child-Pugh A): 12 wk Recommended duration for treatment-experienced patients No cirrhosis Genotype 1 and NS5A inhibitor prior treatment: 16 wk Genotype 1 and NS3/4A...
... Show moreRenal Dose
Renal impairment
Mild, moderate, or severe, including patients on dialysis: No dosage adjustment required
Contraindication
Severe hepatic impairment (Child-Pugh C)
Coadministration with atazanavir or rifampin
Mode of Action
Glecaprevir: HCV NS3/4A protease inhibitor; necessary for the proteolytic cleavage of the HCV-encoded polyprotein (into mature forms of the NS3, NS4A, NS4B, NS5A, and NS5B proteins) and is essential for viral replication
Pibrentasvir: HCV NS5A inhibitor; essential for viral RNA replication and virion assembly
Precaution
Hepatitis B virus reactivation in patients coinfected with HCV/HBV may occur
Side Effect
>10%
Headache (9-17%)
Fatigue (11-14%)
Nausea (6-12%)
1-10%
Diarrhea (3-7%)
Increased bilirubin, ≥2x ULN (3.5%)
Pruritus (7%)
Pregnancy Category Note
Pregnancy No adequate human data are available to establish whether or not glecaprevir/pibrentasvir poses a risk to pregnancy outcomes Animal studies No adverse developmental effects were observed when glecaprevir and pibrentasvir were administered separately during organogenesis at exposures up to 53 times (rats; glecaprevir) or 51 and 1.5 times (mice and rabbits, respectively; pibrentasvir) the human exposures at the recommended dose Lactation Unknown if distributed in human breast milk When administered to lactating rodents, glecaprevir and pibrentasvir were present in milk, without effect on growth and development observed in the nursing pups Consider the developmental and health benefits of breastfeeding...
... Show moreInteraction
Coadministration is contraindicated with rifampin or atazanavir
Coadministration is not recommended with carbamazepine, efavirenz, or St John’s wort
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