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Xorest 0.5
Everest Pharmaceuticals Ltd.
Generic: Clonazepam
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Xorest 0.5.
CONSULT YOUR DOCTOR
Xorest 0.5 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Xorest 0.5 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Xorest 0.5 may cause side effects which could affect your ability to drive.
CAUTION
Xorest 0.5 should be used with caution in patients with kidney disease. Dose adjustment of Xorest 0.5 may be needed. Please consult your doctor.
Use of Xorest 0.5 can cause excessive sleepiness in patients with end stage kidney disease.
CAUTION
Xorest 0.5 should be used with caution in patients with liver disease. Dose adjustment of Xorest 0.5 may be needed. Please consult your doctor.
Medicine Overview of Xorest 0.5 0.5mg Tablet
Introduction
Xorest 0.5 is a prescription medicine used to treat epilepsy (seizures), panic and anxiety disorder. It helps to decrease the abnormal and excessive activity of the nerve cells and calms the brain. Xorest 0.5 may be taken with or without food. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it has a high potential of habit-forming. If you have missed a dose, take it as soon as you remember it and finish...
... Show moreUses of Xorest 0.5
- Anxiety disorder
- Epilepsy/Seizures
Side effects of Xorest 0.5
Common
- Depression
- Dizziness
- Drowsiness
- Fatigue
- Impaired coordination
How to use Xorest 0.5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Xorest 0.5 may be taken with or without food, but it is better to take it at a fixed time.
How Xorest 0.5 works
Xorest 0.5 is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain.
What if you forget to take Xorest 0.5?
If you miss a dose of Xorest 0.5, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- The addiction / habit-forming potential of this medicine is very high. Take it only as per the dose and duration advised by your doctor
- It may cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you.
- Avoid consuming alcohol as it may increase dizziness and drowsiness.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
- Inform your doctor if you experience worsen anxiety, depression angry, or violent behavior and mania while taking this medicine.
- Do not stop taking medication suddenly without talking to your doctor as that may lead to nausea, anxiety, agitation, flu-like symptoms, sweating, tremor, and confusion.
Brief Description
Indication
Epilepsy, Anxiety disorders, Panic disorder, Status epilepticus, Social phobia, Migraines, Parasomnia, Restless legs syndrome, Rapid eye movement, Behavior disorder, Spasticity, Resistant depression, Trigeminal neuralgia, Nocturnal myoclonus, Post traumatic stress disorder, Insomnia and sleep disturbances, Burning Mouth Syndrome
Administration
May be taken with or without food.
Adult Dose
Oral
Epilepsy
Adult: Initially, 1 mg given at night for 4 days, gradually increased over 2-4 wk. Maintenance: 4-8 mg/day. Max: 20 mg/day.
Elderly: Initially, 0.5 mg at night for 4 days.
Panic disorder
Adult: Initially, 0.25 mg bid, increased after 3 days up to 1 mg/day. Max: 4 mg/day.
Intravenous
Emergency management of status epilepticus
Adult: 1 mg by slow IV inj over at least 2 min or by infusion, repeated if necessary. Max: 20 mg.
Hepatic impairment: Dosage adjustment may be needed.
Child Dose
Oral
Epilepsy
Child: <10 yr or <30 kg: Initially, 0.01-0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in 2 or 3 divided doses. May be increased by no more than 0.25-0.5 mg every 3rd day until seizure control is achieved.
Maintenance: 0.1-0.2 mg/kg/day divided 3 times daily. Max: 0.2 mg/kg/day.
Intravenous
Emergency management of status epilepticus
Child: 500 mcg by slow IV inj or by infusion.
Contraindication
Hypersensitivity to benzodiazepines, acute pulmonary insufficiency, acute narrow angle glaucoma.
Mode of Action
Clonazepam reduces the nerve transmission in the motor cortex which suppresses the spike and wave discharge in absence seizures. Its mechanism is believed to be related to its ability to enhance the activity of GABA. Clinically, it improves focal epilepsy and generalised seizures.
Precaution
Neonates, chronic pulmonary insufficiency, hepatic/renal dysfunction, porphyria, elderly; pregnancy and lactation.
Lactation: Excreted in breast milk; not recommended
Side Effect
>10%
Somnolence (37%)
1-10%
Abnormal coordination (5-10%),Ataxia (5-10%),Depression (5-10%),Dizziness (5-10%),Fatigue (5-10%),Memory impairment (5-10%),Upper respiratory infection (5-10%),Confusion (1-5%),Dysarthria (1-5%),Rhinitis (1-5%),Coughing (1-5%),Urinary frequency (1-5%),Impotence (1-5%),Decreased libido (1-5%)
Frequency Not Defined
Increased salivation,Worsening tonic-clonic seizures
Potentially Fatal: Salivary or bronchial hypersecretion leading to respiratory problems (children). May produce diminished reflexes or coma. Rarely, blood dyscrasias.
Pregnancy Category Note
Pregnancy There are no adequate and well-controlled studies of Klonopin in pregnant women; available human data on risk of teratogenicity are inconclusive; there is insufficient evidence in humans to assess effect of benzodiazepine exposure during pregnancy on neurodevelopment; administration of benzodiazepines immediately prior to or during childbirth can result in a syndrome of hypothermia, hypotonia, respiratory depression, and difficulty feeding; in addition, infants born to mothers who have taken benzodiazepines during later stages of pregnancy can develop dependence, and subsequently withdrawal, during the postnatal period Data for other benzodiazepines suggest possibility of adverse developmental effects (long-term effects on neurobehavioral and...
... Show moreInteraction
Additive depressant effect w/ TCAs, MAOIs, sedative and hypnotics, barbiturates, anxiolytics, antipsychotics, opiate agonists. May increase serum phenytoin levels.
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