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Buflex 500
Beximco Pharmaceuticals Ltd.
Generic: Nabumetone
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Buflex 500.
CONSULT YOUR DOCTOR
Buflex 500 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Buflex 500 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Buflex 500 may cause side effects which could affect your ability to drive.
As may feel dizzy, tired, have problems with your vision or have headaches after taking Buflex 500 and this may affect your ability to drive.
CAUTION
Buflex 500 should be used with caution in patients with kidney disease. Dose adjustment of Buflex 500 may be needed. Please consult your doctor.
Kidney function tests and some other blood tests may advised when you will start with this therapy and then at regular intervals while you are taking this medicine.
CAUTION
Buflex 500 should be used with caution in patients with liver disease. Dose adjustment of Buflex 500 may be needed. Please consult your doctor.
Use of Buflex 500 is not recommended in patients with severe liver disease.
Medicine Overview of Buflex 500mg Tablet
Introduction
Buflex 500 is a pain relieving medicine. It effectively alleviates pain and inflammation in conditions like rheumatoid arthritis and osteoarthritis. Buflex 500 should be taken in the dose and duration as advised by your doctor. It should be taken with food or milk to prevent stomach upset. Inform your doctor if you have any history of heart disease or stroke. Vomiting, stomach pain, nausea and indigestion are some of the common side effects that might be observed on taking this medicine. It may also cause dizziness, drowsiness or visual disturbances. Your doctor may regularly monitor your kidney function, liver function...
... Show moreUses of Buflex 500
- Pain relief
Side effects of Buflex 500
Common
- Vomiting
- Stomach pain/epigastric pain
- Nausea
- Indigestion
- Loss of appetite
- Diarrhea
- Heartburn
How to use Buflex 500
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Buflex 500 is to be taken with food.
How Buflex 500 works
Buflex 500 is a non-steroidal anti-inflammatory drugs (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).
Quick Tips
- You have been prescribed Buflex 500 to relieve pain and inflammation.
- Take it with food or milk to prevent upset stomach.
- Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.
- It may cause dizziness, drowsiness or visual disturbances. Use caution while driving or doing anything that requires concentration.
- Avoid consuming alcohol while taking Buflex 500 as it can cause excessive drowsiness and increase your risk of stomach problems.
- Inform your doctor if you have a history of heart disease or stroke.
- Your doctor may regularly monitor your kidney function, liver function and levels of blood components, if you are taking this medicine for long-term treatment.
Brief Description
Indication
Pain and inflammation associated with musculoskeletal and joint disorders, Osteoarthritis, Rheumatoid Arthritis
Administration
Should taken with food.
Adult Dose
Oral
Adult
Osteoarthritis
1g PO once daily initially; maintenance: 1-2 g/day PO in single daily dose or divided q12hr; not to exceed 2 g/day
Rheumatoid Arthritis
1 g PO once daily initially; maintenance: 1-2 g/day PO in single daily dose or divided q12hr; not to exceed 2 g/day
Elderly: 500 mg daily may be adequate in certain patients. Max: 1 g daily.
Child Dose
Not recommended
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
30-49 Max initial dose: 750 mg once daily. Increase if needed to a max dose of 1.5 g daily.
<30 Max initial dose: 500 mg once daily. Increase if needed to a max dose of 1 g daily.
Contraindication
Absolute: Aspirin allergy, severe renal impairment; perioperative pain in setting of coronary artery bypass graft (CABG) surgery
Relative: Duodenal/gastric/peptic ulcer, stomatitis, systemic lupus erythematosus, ulcerative colitis, late pregnancy (may cause premature closure of ductus arteriosus)
Mode of Action
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase (COX) isoenzymes, COX-1 and COX-2
May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to anti-inflammatory activity
Precaution
Pre-existing CV risk factors or disease; fluid retention, CHF, hypertension. History of GI disease (bleeding or ulcers). Elderly or debilitated patients. Other forms of asthma. Hepatic impairment; closely monitor patients with any abnormal LFT. Renal impairment; rehydrate patient prior to therapy and closely monitor renal function. Withhold for at least 4-6 half-lives prior to surgical or dental procedures.
Side Effect
>10%
Diarrhea (14%),Dyspepsia (13%),Abdominal pain (12%)
1-10%
Constipation (3-9%),Dizziness (3-9%),Edema (3-9%),Flatulence (3-9%),Headache (3-9%),Nausea (3-9%),Positive stool guaiac (3-9%),Pruritus (3-9%),Rash (3-9%),Tinnitus (3-9%),Dry mouth (1-3%),Fatigue (1-3%),Gastritis (1-3%),Increased sweating (1-3%),Insomnia (1-3%),Nervousness (1-3%),Somnolence (1-3%),Stomatitis (1-3%),Vomiting (1-3%)
Pregnancy Category Note
Pregnancy category: C; D if used for prolonged periods or near term (premature closure of ductus arteriosus)
Interaction
Antihypertensive effects of hypotensive agents may be reduced. May increase ciclosporin levels. Increased risk of seizures with fluoroquinolones. May reduce efficacy of diuretics. May diminish the cardioprotective effect of acetylated salicylates. Alcohol may enhance gastric mucosal irritation.
Potentially Fatal: Increased risk of bleeding with anticoagulants (e.g. warfarin, heparin, LMWHs) and antiplatelet agents (e.g. ticlopidine, clopidogrel, aspirin, abciximab, dipyridamole, eptifibatide, tirofiban).
Increased risk of GI ulceration with corticosteroids. Severe bone marrow suppression, aplastic anaemia and GI toxicity may occur with methotrexate.
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