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Zolium XR 2
Incepta Pharmaceuticals Ltd.
Generic: Alprazolam
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Zolium XR 2.
CONSULT YOUR DOCTOR
Zolium XR 2 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Zolium XR 2 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Zolium XR 2 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Zolium XR 2 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Zolium XR 2 may not be needed in these patients. Please consult your doctor.
CAUTION
Zolium XR 2 should be used with caution in patients with liver disease. Dose adjustment of Zolium XR 2 may be needed. Please consult your doctor.
Medicine Overview of Zolium XR 2mg Tablet
Introduction
Zolium XR 2 belongs to a class of medicines known as benzodiazepines. It is a prescription medicine used to treat anxiety. It alters brain activity, calms it and provides relief from panic attacks by relaxing the nerves. Zolium XR 2 may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it has a high potential of habit-forming. If you have missed a dose,...
... Show moreUses of Zolium XR 2
- Anxiety
Side effects of Zolium XR 2
Common
- Lightheadedness
- Drowsiness
How to use Zolium XR 2
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zolium XR 2 may be taken with or without food, but it is better to take it at a fixed time.
How Zolium XR 2 works
Zolium XR 2 is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain.
What if you forget to take Zolium XR 2?
If you miss a dose of Zolium XR 2, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- The addiction / habit-forming potential of this medicine is very high. Take it only as per the dose and duration advised by your doctor
- It may cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you.
- Avoid consuming alcohol as it may increase dizziness and drowsiness.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
- Do not stop taking medication suddenly without talking to your doctor as that may lead to nausea, anxiety, agitation, flu-like symptoms, sweating, tremor, and confusion.
Brief Description
Indication
Oral
Short-term management of anxiety
Adult: 0.25-0.5 mg tid, increased to 3-4 mg daily if necessary.
Elderly: Initially, 0.25 mg bid/tid.
Panic attacks
Adult
Immediate-release
0.5 mg PO q8hr; may increase q3-4Days by ?1 mg/day
Average dose: 5-6 mg/day PO
May require up to 10 mg/day PO divided q8hr
Extended-release
0.5-1 mg PO qDay; may increase q3-4Days by <1 mg/day
Average dose: 3-6 mg PO qDay
Anxiety Associated With Depression
1-4 mg/day PO divided q8hr
Hepatic impairment: Avoid in severe impairment.
Administration
Potentiates action of alcohol and CNS depressants. Reduced conc with cigarette smoking by 50%.
Potentially Fatal: Cimetidine and fluoxetine reduce the clearance of alprazolam. Alprazolam enhances activity of imipramine and desipramine.
Adult Dose
Dosage reduction or gradual withdrawal. Dependence. Geriatric or debilitated patients. Muscle weakness, impaired hepatic or renal function; arteriosclerosis; obesity; depression particularly suicidal tendency; chronic pulmonary insufficiency. May impair ability to drive or operate machinery. Children <18 yr.
Lactation: Enters breast milk/not recommended
Renal Dose
Alprazolam has anxiolytic, muscle-relaxant, anticonvulsant, antidepressant and sleep-modifying effects. It binds to the ? aminobutyric acid (GABA)-specific sites throughout the CNS, leading to an increase in the inhibitory effect of GABA on neuronal excitability. Increased neuronal permeability to chloride ions thus results in hyperpolarisation and stabilisation.
Contraindication
<18 years old: Not recommended
Mode of Action
Administration May be taken with or without food. Side effects eg sleepiness/drowsiness may be reduced if taken immediately after meals.
Precaution
Anxiety disorders, Panic disorders, Nausea due to chemotherapy
Side Effect
Renal impairment: Use caution; not studied
Pregnancy Category Note
>10% (4 mg dose)
Drowsiness (41%),Depression (10-15%),Headache (10-15%),Constipation (10-15%),Diarrhea (10-15%),Dry mouth (10-15%)
>10% (10 mg dose)
Drowsiness (77%),Impaired coordination (40-50%),Increased appetite (30-35%),Fatigue (30-35%),Memory impairment (30-35%),Irritability (30-35%),Decreased salivation (30-35%),Cognitive disorders (20-30%),Insomnia (20-30%),Dcreased appetite (20-30%),Headache (20-30%),Lightheadedness (20-30%),Dysarthria (20-30%),Diarrhea, constipation, and nausea/vomiting (20-30%),Weight change (20-30%),Nasal congestion (15-20%),Decreased or increased libido (10-15%),Menstrual disorder (10-15%),Difficult micturition (10-15%)
1-10% (4 mg dose)
Tachycardia (5-10%),Confusion (5-10%),Insomnia (5-10%),Nausea/vomiting (5-10%),Blurred vision (5-10%),Nasal congestion (5-10%),Hypotension (1-5%),Syncope (1-5%),Akathisia (1-5%),Dizziness (1-5%),Increased salivation (1-5%),Nervousness (1-5%),Tremor (1-5%),Weight change (1-5%)
1-10% (10 mg dose)
Increased salivation (5-10%),Talkativeness (1-5%),Incontinence (1-5%)
Potentially Fatal: Blood dyscrasias.
Interaction
Acute narrow-angle glaucoma, preexisting CNS depression or coma, resp depression, acute pulmonary insufficiency or sleep apnoea; severe hepatic impairment; pregnancy, lactation.
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