12-24 Hours
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Metazine MR
Beximco Pharmaceuticals Ltd.
Generic: Trimetazidine Dihydrochloride
Safety Advices
বাংলা
English
UNSAFE
Metazine MR may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Information regarding the use of Metazine MR during pregnancy is not available. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Metazine MR during breastfeeding is not available. Please consult your doctor.
UNSAFE
Metazine MR may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Metazine MR should be used with caution in patients with kidney disease. Dose adjustment of Metazine MR may be needed. Please consult your doctor.
Use of Metazine MR is not recommended in patients with severe kidney disease.
CONSULT YOUR DOCTOR
There is limited information available on the use of Metazine MR in patients with liver disease. Please consult your doctor.
Medicine Overview of Metazine MR 35mg Tablet
Introduction
Metazine MR is an anti-anginal medicine used for treating heart-related chest pain (angina). It prevents new attacks of angina but does not stop an acute attack once it has started. It can be used alone or in combination with some other medicines. Metazine MR should be taken regularly as advised by the doctor. You should take it with or without food and at a fixed time. Your doctor will decide how often you should take this medicine. This may change from time to time depending on how well it is working. You should take this medicine regularly to get the...
... Show moreUses of Metazine MR
- Angina (heart-related chest pain)
Side effects of Metazine MR
Common
- Constipation
- Dizziness
- Headache
- Nausea
- Vomiting
- Weakness
How to use Metazine MR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Metazine MR may be taken with or without food, but it is better to take it at a fixed time.
How Metazine MR works
Metazine MR is an anti-anginal medication. It decreases the oxygen requirement of the heart by shifting its metabolism from fats to glucose. As a result, the heart works more efficiently.
What if you forget to take Metazine MR?
If you miss a dose of Metazine MR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Metazine MR prevents new attacks of angina but does not stop an acute attack.
- Does not affect heart rate, blood pressure at rest or during exercise.
- Improves HbA1c and blood sugar levels in diabetes patients.
- Avoid driving or using machinery if you feel dizzy after taking Metazine MR.
Brief Description
Indication
Ischaemic heart disease, Angina pectoris, Coronary heart disease
Administration
Should be taken with food.
Adult Dose
Oral
Angina pectoris
Adult: 40-60 mg daily in 2-3 divided doses.
Modified-release tab: 35 mg bid.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<30 Contraindicated.
30-60 20 mg bid. Modified-release: 35 mg once daily.
Contraindication
Hypersensitivity to Trimetazidine Dihydrochloride.
Mode of Action
Trimetazidine is a cellular acting anti-ischaemic agent. It has 3 main properties by which it acts as a cytoprotective agent. It inhibits the anaerobic glycolysis and fatty acid metabolism, thus allowing only aerobic glycolysis. This action helps to restore the energy balance in the cell. It inhibits acidosis and free radical accumulation in the cell. All these action help the cell to restore the normal ionic and metabolic balance.
Precaution
Moderate renal impairment (CrCl 30-60 mL/min). Pregnancy. Patient Counselling May cause dizziness and drowsiness, if affected, do not drive or operate machinery. Although teratological studies have not shown any drug related adverse effects on the course and outcome of pregnancy, the use in pregnant women is not recommended.
It is not known whetherTrimetazidine passes into breast milk or not. This medication should be used while breast feeding only if the potential benefits outweigh risks to the nursing infants.
Side Effect
Dizziness, headache, abdominal pain, dyspepsia, diarrhoea, nausea, vomiting, pruritus, rash, urticaria, asthenia. Rarely, tachycardia, palpitations, extrasystoles, orthostatic hypotension, arterial hypotension, flushing.
Interaction
MAOIs, nifedipine. May potentiate the effects of other antianginals.
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