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Chloramphenicol
Hudson Pharmaceuticals Ltd.
Generic: Chloramphenicol
Safety Advices
বাংলা
English
UNSAFE
Consuming alcohol while taking Chloramphenicol may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
CONSULT YOUR DOCTOR
Chloramphenicol may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Chloramphenicol is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Chloramphenicol may cause blurring of your vision for a short time just after its use. Do not drive until your vision is clear.
SAFE IF PRESCRIBED
Chloramphenicol is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Chloramphenicol may not be needed in these patients. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Chloramphenicol in patients with liver disease. Please consult your doctor.
Medicine Overview of Chloramphenicol 250mg Capsule
Introduction
Chloramphenicol is an antibiotic that fights bacteria. It is used to treat certain types of serious infections caused by bacteria when other antibiotics cannot be used. It works by killing the bacteria that cause these problems. However, it will not treat a viral infection. Chloramphenicol may be effective even when bacteria have developed resistance to other antibiotics. It should be taken on an empty stomach. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose...
... Show moreUses of Chloramphenicol
- Bacterial infections
Side effects of Chloramphenicol
Common
- Vomiting
- Nausea
- Diarrhea
- Taste change
How to use Chloramphenicol
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Chloramphenicol is to be taken empty stomach.
How Chloramphenicol works
Chloramphenicol is an antibiotic which stops the growth of bacteria. It does so by preventing synthesis of essential proteins required by bacteria to carry out vital functions. This does not directly kill the bacteria, but prevents them from increasing in numbers, and eventually clears up the infection.
Quick Tips
- Your doctor has prescribed Chloramphenicol to cure your infection and improve your symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
- Your doctor may get blood tests done to check your blood cells before starting treatment and regularly thereafter.
- Do not use Chloramphenicol if you are pregnant, planning to conceive, or breastfeeding.
- Inform your doctor if you have liver or kidney disease.
Brief Description
Indication
Tetracycline-resistant cholera, typhoid, brain abscesses, meningitis, Granuloma inguinale, Anthrax, Listeriosis, Gas gangrene, Whipple's disease, gastroenteritis, melioidosis, Plague, Psittacosis, Q fever, Tularaemia
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Adult Dose
Adult: PO Susceptible infections 50 mg/kg/day in 4 divided doses, may increase to 100 mg/kg/day in more severe infections.
Hepatic impairment: Dose reduction may be required.
Child Dose
PO Susceptible infections
Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses.
Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses.
Children: 50-75 mg/kg/day in 4 divided doses increased to 75-100 mg/kg/day for meningitis or severe infections.
Renal Dose
Renal impairment: Dose reduction may be required.
Contraindication
History of hypersensitivity or toxic reaction to the drug; pregnancy, lactation; porphyria; parenteral admin for minor infections or as prophylaxis; preexisting bone marrow depression or blood dyscrasias.
Mode of Action
Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.
Precaution
Impaired renal or hepatic function; premature and full-term neonates. Monitor plasma concentrations to avoid toxicity.
Lactation: enters breast milk; discontinue drug or do not nurse
Side Effect
<1%
Nightmares,Headache,Rash,Diarrhea,Stomatitis,Enterocolitis,Nausea,Vomiting,Bone marrow suppression,Aplastic anemia,Peripheral neuropathy,Optic neuritis,Gray syndrome
Potentially Fatal: Bone marrow suppression and irreversible aplastic anaemia. Neutropenia, thrombocytopenia. Grey baby syndrome. Rarely, anaphylaxis.
Pregnancy Category Note
Pregnancy Category: C
Lactation: enters breast milk; discontinue drug or do not nurse
Interaction
Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives.
Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function.
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