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Avapag 20
Everest Pharmaceuticals Ltd.
Generic: Avatrombopag
Medicine Overview of Avapag 20mg Tablet
বাংলা
English
Indication
Thrombocytopenia
Administration
Take with food
Adult Dose
Thrombocytopenia Patients with chronic liver disease Indicated for thrombocytopenia in adults with chronic liver disease who are scheduled to undergo a procedure Taken orally once daily for 5 consecutive days with food Initiate dosing 10-13 days prior to the scheduled procedure Patients should undergo their procedure 5-8 days after the last dose Dose based on preprocedure platelet count Platelet count 400 x10^9/L: Stop avatrombopag and increase platelet monitoring to twice weekly; may reinitiated by decreasing 1 dose level when platelets 400 x10^9/L after 2 weeks at 20 mg/week: Discontinue avatrombopag Dose levels for titration in ITP Dose level 6: 40...
... Show moreRenal Dose
Renal impairment
Mild-to-moderate (CrCl ?30 mL/min): No dose adjustment required; minimally excreted by the kidneys
Severe (CrCl <30 mL/min) or hemodialysis: Unknown
Mode of Action
Second-generation orally administered thrombopoietin receptor agonist (TPO-RA)
Stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells, resulting in an increased production of platelets
Does not compete with TPO for binding to the TPO receptor and has an additive effect with TPO on platelet production
Precaution
Thrombotic/thromboembolic complications Thrombopoietin (TPO) receptor agonists associated with thrombotic and thromboembolic complications in patients with chronic liver disease or chronic ITP Portal vein thrombosis reported with chronic liver disease in patients treated with thrombopoietin (TPO) receptor agonists (ADAPT-1 and ADAPT-2 clinical trials) Consider the potential increased thrombotic risk when administering to patients with known risk factors for thromboembolism, including genetic prothrombotic conditions (eg, factor V Leiden, prothrombin 20210A, antithrombin deficiency, or protein C or S deficiency) Not to be administered to patients with chronic liver disease or chronic immune thrombocytopenia in an attempt to normalize platelet counts; thromboembolic events (arterial...
... Show moreSide Effect
>10%
Pyrexia (8-11%)
1-10%
Abdominal pain (6-7%)
Nausea (6-7%)
Headache (4-7%)
Fatigue (3-4%)
Peripheral edema (3-4%)
<1%
Hyponatremia (0.7%)
Pregnancy Category Note
Pregnancy Based on findings from animal reproduction studies, may cause fetal harm when administered to pregnant women In animal reproduction studies, administration resulted in adverse developmental outcomes when administered during organogenesis in rabbits and during organogenesis and the lactation period in rats However, these findings were observed at exposures based on AUC substantially higher than the AUC observed in patients at the recommended dose of 60 mg once daily Advise pregnant women of the potential risk to a fetus Lactation No data are available regarding the presence of the drug in human milk, the effects on the breastfed child, or...
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