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Hexirest 2
Everest Pharmaceuticals Ltd.
Generic: Trihexyphenidyl Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
Hexirest 2 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Hexirest 2 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Hexirest 2 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Hexirest 2 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Hexirest 2 can cause blurring of vision, dizziness, mild nausea, and mental confusion in some cases. This may affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Hexirest 2 in patients with kidney disease. Please consult your doctor.
Patients with kidney disease should be closely monitored by a doctor while taking this medicine.
CONSULT YOUR DOCTOR
There is limited information available on the use of Hexirest 2 in patients with liver disease. Please consult your doctor.
Medicine Overview of Hexirest 2mg Tablet
Introduction
Hexirest 2 is used with other medicines to treat Parkinson’s disease. It’s also used to treat severe movement side effects caused by certain drugs (drug-induced movemnet disorder). Hexirest 2 should be taken empty stomach as it reduces the side effects of this medicine. It should be taken at the same time each day, this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the...
... Show moreUses of Hexirest 2
- Parkinson's disease
- Drug induced abnormal movements
Side effects of Hexirest 2
Common
- Dryness in mouth
- Nausea
- Vomiting
- Constipation
- Blurred vision
- Dizziness
- Upset stomach
- Headache
- Difficulty in urination
- Nervousness
How to use Hexirest 2
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Hexirest 2 is to be taken empty stomach.
How Hexirest 2 works
Hexirest 2 is an anticholinergic medication. It works by decreasing the activity of a chemical messenger (acetylcholine) in the brain. This improves muscle control and reduces stiffness in Parkinson's disease. It also improves movement disorder (restlessness, involuntary movements or muscle spasm) caused by certain other medicines.
Quick Tips
- Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
- It may cause dry eyes. Avoid wearing contact lenses and inform your doctor if it bothers you.
- It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Monitoring of intraocular pressure is required while taking this medicine, as an increase in eye pressure may cause blurry vision.
- Inform your doctor if you suffer from glaucoma or if you have trouble passing urine.
Brief Description
Indication
Extrapyramidal symptoms, Parkinsonism (postencephalitic, arteriosclerotic & idiopathic)
Administration
Should be taken with food. Best taken w/ meals. Take before meals if dry mouth occurs, after meals if drooling/nausea occurs. Take at the same time each day.
Adult Dose
Oral
Drug-induced extrapyramidal symptoms
Adult: 5-15 mg/day PO divided q6-8hr
Parkinson Disease
Adult: Initially, 1 mg daily, gradually increased at intervals of 3-5 days by increments of 2 mg until 6-10 mg daily in 3-4 divided doses.
Maintenance: 5-15 mg/day PO divided q6-8hr
Parkinsonism
Adult: 5-15 mg/day PO divided q6-8hr
Elderly: May require lower doses.
Child Dose
Safety and efficacy not established
Contraindication
Patients with closed-angle glaucoma, chronic pulmonary disease, sick sinus syndrome, thyrotoxicosis, cardiac failure with tachycardia.
Mode of Action
Trihexyphenidyl HCl is a tertiary amine antimuscarinic which exerts a direct inhibitory effect on the parasympathetic nervous system. It also exhibits a direct spasmolytic action on smooth muscle, weak mydriatic, antisialagogue and cardiovagal blocking effects.
Precaution
Patient w/ arteriosclerosis, history of drug idiosyncrasy. CV disease, glaucoma, GI obstruction, prostatic hyperplasia and/or urinary stricture. Not intended for treatment of tardive dyskinesia. Avoid abrupt withdrawal. Hepatic and renal impairment. Elderly. Pregnancy and lactation. Patient Counselling May impair mental or physical abilities e.g. operating machinery or driving. Monitoring Parameters Perform gonioscopic examination prior to initiation of therapy. Monitor intraocular pressure at regular intervals during prolonged treatment.
Side Effect
>10%
Anticholinergic side effects (30-50%), Rash
<1%
Suppurative parotitis,Hallucination,Paralytic ileus
Interaction
Increased antimuscarinic side effects w/ phenothiazines, clozapine, antihistamines, disopyramide, nefopam and amantadine. Synergistic effect when concomitantly used w/ TCAs. Concurrent admin w/ MAOIs may cause dry mouth, blurred vision, urinary hesitancy or retention and constipation. May antagonise effect of metoclopramide and domperidone on GI function. Reduced absorption of levodopa. May antagonise effect of parasympathomimetics.
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