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Nilonix 200
Beacon Pharmaceuticals PLC
Generic: Nilotinib
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Nilonix 200 does not cause any harmful side effects.
CONSULT YOUR DOCTOR
Nilonix 200 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Nilonix 200 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Nilonix 200 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Nilonix 200 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Nilonix 200 may not be needed in these patients. Please consult your doctor.
CAUTION
Nilonix 200 should be used with caution in patients with liver disease. Dose adjustment of Nilonix 200 may be needed. Please consult your doctor.
Medicine Overview of Nilonix 200mg Capsule
Introduction
Nilonix 200 is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects. Nilonix 200 should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take...
... Show moreUses of Nilonix 200
- Blood cancer (Chronic myeloid leukaemia)
Side effects of Nilonix 200
Common
- Headache
- Nausea
- Abdominal pain
- Rash
- Itching
- Hair loss
- Muscle pain
- Fatigue
How to use Nilonix 200
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Nilonix 200 is to be taken empty stomach.
How Nilonix 200 works
Nilonix 200 is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
What if you forget to take Nilonix 200?
If you miss a dose of Nilonix 200, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Nilonix 200 is used for the treatment of thyroid cancer.
- Take it with or without food, preferably at the same time each day.
- Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
- Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
- It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
- Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
Brief Description
Indication
Chronic myelogenous leukaemia
Administration
Should be taken on an empty stomach. Avoid food at least 2 hr before & at least 1 hr after a dose. Swallow whole, do not chew/crush. Avoid grapefruit products.
Adult Dose
Oral Chronic Myeloid Leukemia (CML), Newly Diagnosed Indicated for initial treatment of newly diagnosed Philadelphia chromosome positive chronic phase chronic myeloid leukemia (Ph+ CP-CML) 300 mg PO q12hr Chronic Myeloid Leukemia (CML), Resistant/Intolerant Indicated for treatment of chronic phase and accelerated pase Ph+ CML in patients resistant to or intolerant to prior therapy that included imatinib 400 mg PO q12hr Hepatic Impairment Newly diagnosed Ph+ CML (chronic phase at 300 mg BID) Mild, moderate, or severe hepatic impairment: Start initial dose at 200 mg BID; if tolerated, may increase to 300 mg BID Resistant or intolerant Ph+ CML (chronic phase...
... Show moreChild Dose
<18 years old: Not recommended
Contraindication
Patients with hypokalaemia, hypomagnaesemia or long QT syndrome. Pregnancy.
Mode of Action
Nilotinib is a potent inhibitor of BCR-ABL tyrosine kinase. It binds to and stabilises the inactive conformation of the kinase domain of Abl protein.
Precaution
Patient w/ history of pancreatitis, w/ total gastrectomy. Hepatic impairment. Maintain adequate hydration and correct uric acid levels, hypomagnesaemia, hypokalaemia and other electrolyte imbalances prior to therapy. Pregnancy and lactation. Monitoring Parameters Monitor ECG, CBC, hepatic function, serum lipase regularly. Monitor electrolyte periodically during therapy.
Lactation: not known if excreted in breast milk; do not nurse
Side Effect
>10%
Rash (33%),Headache (31%),Nausea (31%),Pruritus (29%),Fatigue (28%),Pyrexia (24%),Diarrhea (22%),Constipation (21%),Vomiting (21%),Arthralgia (18%),Cough (17%),Extremity pain (16%),Asthenia (14%),Muscle spasms (14%),Myalgia (14%),Abdominal pain (13%),Bone pain (13%),Back pain (12%),Dyspnea (11%),Nasopharyngitis (11%),Peripheral edema (11%)
1-10% (selected)
Dizziness,Insomnia,Paresthesia,QT interval prolongation,HTN,Palpitations,QT interval prolongation,Hyperglycemia,Hyperkalemia,Hypomagnesemia,Neutropenia,Pancytopenia
<1%
Peripheral arterial occlusive disease,Tumor lysis syndrome,Aortic valve sclerosis,Abscess,Amnesia,Dehydration
Potentially Fatal: QT prolongation and sudden deaths.
Interaction
Drugs that inhibit gastric acid secretion (e.g. PPIs) may reduce solubility and bioavailability of nilotinib.
Potentially Fatal: Concomitant use w/ potent CYP3A4 inhibitors or antiarrhythmics (e.g. amiodarone, disopyramide, quinidine, sotalol, ketoconazole, clarithromycin, atazanavir) and other QT prolonging drugs (e.g. chloroquine, haloperidol, methadone, moxifloxacin, pimozide) may increase nilotinib serum levels and/or increase the risk of QT prolongation. Concomitant use w/ potent CYP3A4 inducers (e.g. rifampcin, phenobarbital, carbamazepine, phenytoin) may decrease nilotinib serum levels.
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