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Semglee
Beximco Pharmaceuticals Ltd.
Generic: Insulin Glargine
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Semglee.
CONSULT YOUR DOCTOR
Semglee may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Semglee is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
CAUTION
Semglee should be used with caution in patients with kidney disease. Dose adjustment of Semglee may be needed. Please consult your doctor.
Regular monitoring of blood glucose levels is recommended for dose adjustment.
CAUTION
Semglee should be used with caution in patients with liver disease. Dose adjustment of Semglee may be needed. Please consult your doctor.
Regular monitoring of glucose levels is recommended for dose adjustment.
Medicine Overview of Semglee 100IU/ml SC Injection
Introduction
Semglee is a long-acting type of insulin used to treat types 1 and 2 diabetes mellitus in both adults and children. It provides a steady level of insulin in the body for an entire day and helps control blood sugar levels. This helps to prevent complications of diabetes. Semglee can be prescribed alone or along with fast-acting insulin or other diabetes medicines. Your doctor or nurse will teach you the correct way of injecting it under the skin. You should use this medicine regularly as per the dose advised to get the maximum benefit. If you stop taking it, your...
... Show moreUses of Semglee
- Diabetes mellitus (Type 1 & Type 2)
Side effects of Semglee
Common
- Hypoglycemia (low blood glucose level)
- Injection site allergic reaction
- Lipodystrophy (skin thickening or pits at the injection site)
How to use Semglee
Your doctor or nurse will guide you how to use this medicine.
How Semglee works
Semglee is a long-acting insulin that provides consistent, all-day sugar control. It works like your body's natural insulin. Insulin facilitates reuptake of sugar in muscle and fat cells and also suppresses the production of sugar in the liver.
Quick Tips
- Lantus 100IU/ml Solution for Injection is injected under the skin. It needs to be injected once daily, at the same time every day.
- Injection below the skin of the abdomen results in faster absorption than other injection sites.
- Injection sites must be rotated to prevent hard lumps from developing at one site.
- Exercise regularly, eat a healthy diet and take your other diabetes medicines (if prescribed) alongside.
- Hypoglycemia (low blood sugar level) is a common side effect. Hence, regular monitoring of blood sugar levels is required while taking this medicine.
- Always carry some high sugar food such as sugar candy or glucose candy, fruit juice and glucose/glucon-D with you so that you can take it when you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremors, weakness, and anxiety.
- Opened vials/cartridge stay good at room temperature for up to 4 weeks, while unopened vials must be placed in the refrigerator (2°C–8°C).
- Do not use if the preparation is no longer clear and colorless, or if it contains particles.
Brief Description
Indication
Diabetes mellitus
Administration
Administer subcutaneously in the upper arm, thigh or abdominal wall. A subcutaneous injection into the abdominal wall results in a faster absorption than from other injection sites.
Should not be administered IV or via an insulin pump; IV administration of the usual SC dose could result in severe hypoglycemia
Adult Dose
Subcutaneous Type 1 or 2 Diabetes Mellitus Initial dose Type 1 diabetes mellitus: Starting dose should be approximately one third of the total daily insulin requirements; short-acting, premeal insulin should be used to satisfy the remaining two thirds of the daily insulin requirements; insulin glargine should be used in combination with a short-acting or rapid-acting insulin; Type 2 diabetes mellitus: Starting dose in patients who are not currently treated with insulin is 10 units (or 0.2 unit/kg) once daily Dosage should be individualized in accordance with the needs of the patient and adjusted according to blood glucose measurement Converting from...
... Show moreChild Dose
Type 1 Diabetes Mellitus
It is a long-acting human insulin analogue indicated to improve glycemic control in children with type 1 diabetes mellitus;
6 years: Approximately one third of the total daily insulin requirements SC; rapid-acting or short-acting, premeal insulin should be used to satisfy the remaining two thirds of the daily insulin requirements; usual daily maintenance range in adolescents is <1.2 units/kg/day during growth spurts
Renal Dose
Renal impairment: Dose adjustments may be needed.
Contraindication
Hypoglycaemia; IV route.
Mode of Action
Insulin glargine, a long-acting analog of human insulin, regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal.
Precaution
Renal or hepatic impairment; pregnancy; lactation; child <6 yrs. Transferring from other insulin. Monitor serum glucose, potassium, electrolytes, HbA1c and lipid profile. Concomitant illness esp infections; hypokalaemia.
Lactation: Considered safe for use while breast feeding
Side Effect
Hypoglycaemia, lipodystrophy, pruritus, rash, wt gain, sodium retention and oedema. Inj site reactions e.g. pain, itching, hives, swelling and inflammation. Influenza-like symptoms, Pallor, Palpitation, Tachycardia, Mental confusion, Weakness, Blurred vision, Itching, Hunger, Nausea.
Interaction
Effects may be increased by: oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog (e.g. octreotide), sulfonamide antibiotics. Effects may be decreased by: corticosteroids, niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazine derivatives, somatropin, thyroid hormones, oral contraceptives, lithium. Signs of hypoglycaemia may be masked by beta-blockers, clonidine.
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