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Ranola ER 500
General Pharmaceuticals Ltd.
Generic: Ranolazine
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Ranola ER 500. Please consult your doctor.
CONSULT YOUR DOCTOR
Ranola ER 500 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Ranola ER 500 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
CONSULT YOUR DOCTOR
It is not known whether Ranola ER 500 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CAUTION
Ranola ER 500 should be used with caution in patients with kidney disease. Dose adjustment of Ranola ER 500 may be needed. Please consult your doctor.
Use of Ranola ER 500 is not recommended in patients with severe kidney disease.
CAUTION
Ranola ER 500 should be used with caution in patients with liver disease. Dose adjustment of Ranola ER 500 may be needed. Please consult your doctor.
Use of Ranola ER 500 is not recommended in patients with moderate to severe liver disease.
Medicine Overview of Ranola ER 500mg Tablet
Introduction
Ranola ER 500 is a medicine used for the management of angina (heart-related chest pain). It helps to prevent new attacks of angina, but it does not stop an acute attack, once it has started. It relieves chest pain by making the heart work more efficiently. Ranola ER 500 should be taken in the dose as advised by your doctor, at the same time each day. It should be taken with food to avoid stomach upset. Your doctor will decide how often you should take this medicine. This may change from time to time depending on how well it is...
... Show moreUses of Ranola ER 500
- Angina (heart-related chest pain)
Side effects of Ranola ER 500
Common
- Nausea
- Vomiting
- Headache
- Dizziness
- Constipation
- Weakness
How to use Ranola ER 500
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ranola ER 500 is to be taken with food.
How Ranola ER 500 works
Ranola ER 500 is an anti-anginal medication. It works by decreasing the oxygen requirement of the heart by relaxing heart muscle.
What if you forget to take Ranola ER 500?
If you miss a dose of Ranola ER 500, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- It should be taken with food to avoid stomach upset.
- It improves HbA1c and blood sugar levels in diabetes patients.
- It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Notify your doctor if you are taking any other medications along with Ranozex Tablet ER
- It may produce changes in the ECG (QTc interval prolongation). It is recommended to get an ECG done within 1 to 2 weeks of starting the medication.
Brief Description
Indication
Chronic angina
Administration
May be taken with or without food.
Adult Dose
Oral
Chronic angina
500 mg PO BID initially; may increase to 1,000 mg PO BID, if needed
Hepatic Impairment: Mild: Dose titration needed. Moderate to severe: Contraindicated.
Renal Dose
Renal Impairment
Mild to moderate (CrCl 30-80 mL/min): Dose titration needed. Severe (CrCl <30 mL/min): Contraindicated.
Contraindication
Taking strong inhibitors of CYP3A (e.g., ketoconazole, clarithromycin, nelfinavir) Taking inducers of CYP3A (e.g., phenobarbital, rifampicin)Significant hepatic impairment
Mode of Action
Ranolazine exert its antianginal and anti-ischaemic effects through concentration-, voltage-, and frequency-dependent inhibition of the late Na current and other cardiac ion channels and transporters. It may decrease the magnitude of the late Na current resulting in a net reduction in intracellular Na concentrations, reversal of Ca overload, restoration of ventricular pump function, and prevention of ischaemia-induced arrhythmias. Its antianginal effects are not dependent upon reductions in heart rate or BP and QT interval prolongation effect is caused by inhibition of rapid delayed rectifier K current (IKr), which prolongs the ventricular action potential.
Precaution
Heart rhythm problems (e.g., bradycardia, QT prolongation, ventricular tachycardia), liver problems, certain uncorrected mineral imbalances (low potassium/magnesium levels), severe kidney problems.
Lactation: Unknown if excreted in breast milk; discontinue or do not nurse
Side Effect
>10%
Dizziness (5-13%)
1-10%
Nausea (4-9%),Constipation (5-8%),Headache (3-6%),Syncope (3%)
Frequency Not Defined
Palpitations,Bradycardia,Peripheral edema,Prolonged QT interval,Abdominal pain,Dry mouth,Dyspepsia,Anorexia,Vomiting,Hematuria,Dyspnea,Tinnitus,Vertigo,Blurred vision,Vasovagal syncope,Confusional state,Hematuria,Hyperhidrosis
Interaction
Increased plasma levels w/ moderate CYP3A4 inhibitors (e.g. diltiazem, fluconazole, erythromycin), P-glycoprotein inhibitors (e.g. verapamil, ciclosporin) and CYP2D6 inhibitors (e.g. paroxetine). May increase plasma digoxin concentrations. May increase risk of rhabdomyolysis w/ simvastatin. May increase plasma concentrations of atorvastatin, other statins (e.g. lovastatin) and CYP3A4 substrates w/ narrow therapeutic range (e.g. tacrolimus, sirolimus, everolimus). May increase plasma exposure of metformin. Increased risk of ventricular arrhythmias w/ other drugs that prolong QT interval (e.g. terfenadine, astemizole, mizolastine). Potentially Fatal: Increased plasma concentrations leading to increased adverse effects w/ CYP3A4 inhibitors (e.g. itraconazole, ketoconazole, HIV protease inhibitors, clarithromycin, telithromycin, nefazodone). Decreased plasma...
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