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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Ragil 1.
CONSULT YOUR DOCTOR
Ragil 1 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Ragil 1 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Ragil 1 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Ragil 1 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Ragil 1 may not be needed in these patients. Please consult your doctor.
CAUTION
Ragil 1 should be used with caution in patients with liver disease. Dose adjustment of Ragil 1 may be needed. Please consult your doctor.
Use of Ragil 1 is not recommended in patients with moderate and severe liver disease.
Medicine Overview of Ragil 1mg Tablet
Introduction
Ragil 1 is a medicine used to treat Parkinson's disease. It helps to provide better control of body movements and prevents excessive shaking and stiffness. It increases the concentration of a chemical in the brain called dopamine that plays a major role in movement control. Ragil 1 can be taken alone or in combination with other medicines. It may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as...
... Show moreUses of Ragil 1
- Parkinson's disease
Side effects of Ragil 1
Common
- Joint pain
- Insomnia (difficulty in sleeping)
- Indigestion
- Flu-like symptoms
- Depression
- Cough
- Peripheral edema
How to use Ragil 1
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ragil 1 may be taken with or without food, but it is better to take it at a fixed time.
How Ragil 1 works
Ragil 1 works by increasing the amount of dopamine, a chemical messenger that is needed to control movement in the brain.
Quick Tips
- You have been prescribed Ragil 1 to treat your symptoms of Parkinson's disease.
- It can be taken with or without food or as directed by your doctor.
- Be cautious while driving or doing anything that requires concentration as Ragil 1 can make you very sleepy.
- Ragil 1 can make you dizzy or lightheaded, especially when you suddenly stand up from sitting or laying down.
- Let your doctor know if you are also taking medicines for depression or mood disorders.
- Do not stop taking Ragil 1 suddenly. Sudden stopping may cause confusion, stiff muscles and a high fever.
- As a precaution, foods high in tyramine (e.g. aged cheeses, air-dried meat, soy sauce, tap/draft beers and red wine) should be avoided when taking Ragil 1, as it may cause an unsafe rise in your blood pressure.
Brief Description
Indication
Parkinson Disease
Administration
May be taken with or without food. Avoid tyramine-rich foods, beverages or dietary supplements & amines (from cough/cold prep).
Adult Dose
Parkinson Disease
Monotherapy: 1 mg PO qDay
Adjunct without levodopa: 1 mg PO qDay
Adjunct to levodopa: 0.5 mg PO qDay initially, may increase to 1 mg/day if needed and tolerated; consider reducing levodopa dose
Hepatic impairment
Mild (Child-Pugh A): Not to exceed 0.5 mg/day
Moderate-to-severe (Child-Pugh B/C): Do not use
Child Dose
<18 years: Safety and efficacy not established
Renal Dose
Renal impairment: No dosage adjustment required for mild-to-moderate; not studied in severe
Contraindication
Severe hepatic impairment. Concomitant use w/ other MAOIs and pethidine w/in 14 days after discontinuation of therapy; St John's wort.
Mode of Action
Rasagiline is a potent, irreversible monoamine oxidase (MAO)-B selective inhibitor which may cause an increase in extracellular levels of dopamine in the striatum, leading to reduced symptomatic motor deficits of Parkinson's disease.
Precaution
May cause hypertension (including severe hypertensive syndromes) at recommended doses May exacerbate hypertension; antihypertensive drugs may require dosage adjustment May cause hypotension, especially orthostatic May cause serotonin syndrome when used with antidepressants Daytime drowsiness and somnolence reported during activities of daily living May cause or exacerbate dyskinesia; decreasing the levodopa dose may lessen or eliminate this side effect Hallucinations and psychotic-like behavior reported Impulse control/compulsive behaviors reported; case reports describe patients with intense urges to gamble, increased sexual urges, intense urges to spend money, or binge eat Withdrawal-emergent hyperpyrexia and confusion reported with rapid dose reduction of drugs that increase...
... Show moreSide Effect
>10%
EPS (dyskinesia/dystonia) (18%)
Headache (14%)
Nausea (10-12%)
1-10%
Postural hypotension (6-9%)
Constipation (4-9%)
Weight loss (2-9%)
Arthralgia (7%)
Dyspepsia (7%)
Xerostomia (2-6%)
Depression (5%)
Fall (5%)
Flu-like syndrome (5%)
Hallucination (4-5%)
Conjunctivitis (3%)
Fever (3%)
Gastroenteritis (3%)
Rhinitis (3%)
Arthritis (2%)
Bruising (2%)
Malaise (2%)
Neck pain (2%)
Parasthesia (2%)
Vertigo (2%)
<1%
CV
MI
Bundle branch block
Gastrointestinal hemorrhage
Interaction
Increased plasma levels w/ potent CYP1A2 inhibitors (e.g. ciprofloxacin). Increased clearance w/ entacapone.
Potentially Fatal: Increased risk of non-selective MAO inhibition w/ other MAOIs and pethidine that may lead to hypertensive crises.
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