Methicap

It is used for the treatment and prevention of- Liver disease, (non-alcoholic & alcoholic) , Liver cirrhosis, (non-alcoholic & alcoholic) Infectious hepatitis, Drug-induced hepatitis, Liver disease secondary to diabetes mellitus, Toxicity of narcotics, Fatty liver, Jaundice.

Administered only orally as advised by the physician.

1 to 3 capsule(s) should be taken into 2 to 3 times daily or medication should be continued until the relief of symptoms according to the advice of physician.

It should not be given to children without advice of physician. Uses for below 12 years recommended after discussion with registered physician.

It should be used with caution in patients with kidney disease. Dose adjustment of Silymarin [Milk thistle] may be needed. Please consult your doctor.

Contraindicated in patient with a known hypersensitivity to silymarin.

Different mechanisms of action of silymarin are as follow: Increasing the regenerative ability of the liver cells by enhancing the synthesis of DNA and RNA, as silymarin has a steroid structure; Altering the structure of the hepatocyte external membrane, that prevents entrance of the xenobiotics into the cell (poisoning with Amanita mushroom is a noteworthy example of such mechanism); Scavenging free radicals and increasing the cellular content of glutathione that leads to the inhibition of lipid peroxidation; Another mechanism of action of silymarin is modifying the transporters and receptors of cell membranes such as ABC transporters (P-gp), organic anion uptake transporter peptides (OATP), bile salt export pump, and TNF-α-dependent transporters.

Over doses may mildly elevate blood pressure. Safety in young children or individuals with severe hepatic or renal disease is not known.

Occasionally a mild laxative effect may observe. Well tolerated in the recommended dose.

Therefore, if needed Silymarin should be taken with caution according to the physician’s advice. No established evidence is available about the use of Silymarin during pregnancy and lactation.

Concomitant use of silymarin and butyrophenones or phenothiazines has resulted in the reduction of lipid peroxidation.

Store in a cool & dry place, away from light & moisture. Keep out of reach of children.