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Azobrin Plus
Healthcare Pharmaceuticals Ltd.
Generic: Brinzolamide 1% + Brimonidine Tartrate 0.2% eye prep
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
Azobrin Plus may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Azobrin Plus is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Azobrin Plus may cause side effects which could affect your ability to drive.
Azobrin Plus may cause blurred or abnormal vision. This effect may seem worse at night or in reduced lighting and this may affect the ability to drive.
Medicine Overview of Azobrin Plus 1%+0.2% Drop
Introduction
Azobrin Plus is a prescription medicine having a combination of medicines that is used to treat glaucoma. It works by decreasing the pressure of fluid in the eye (aqueous humor), which helps in lowering the increased eye pressure. Azobrin Plus is to be used only in the affected eye in the dose and duration as advised by the doctor. Wash your hands before using this medicine. It is advised to check the label for directions before use. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may...
... Show moreUses of Azobrin Plus
- Glaucoma
Side effects of Azobrin Plus
Common
- Irritation
- Burning sensation in eye
- Stinging sensation
- Blurred vision
- Eye redness
- Tiredness
- Drowsiness
- Headache
- Dryness in mouth
- Taste change
How to use Azobrin Plus
This medicine is for external use only. Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid.
How Azobrin Plus works
Azobrin Plus is a combination of two medicines: Brinzolamide and Brimonidine. Brinzolamide is a carbonic anhydrase inhibitor while Brimonidine is a sympathomimetic. They work by decreasing the production of aqueous humour (fluid in the eye), thereby lowering the increased eye pressure.
Quick Tips
- Azobrin Plus is a combination of two medicines that lowers high pressure in the eye and reduces the risk of vision loss.
- Apply pressure on the corner of the eye (close to the nose) for about 1 minute, immediately after instilling the drop.
- If you wear soft contact lenses, remove them before putting in these eye drops and wait at least 15 minutes before putting your lenses back in.
- Do not touch the tip of the dropper to any surface, or to your eye, to avoid contaminating the eye drops.
- Wait for at least 5-10 minutes before delivering the next medication in the same eye to avoid dilution.
- It may cause short term blurring of vision when first used. Use caution before driving or using machines.
- It may cause temporary burning or itching sensation in the eye. Inform your doctor if this does not go away.
- Make sure to use within 4 weeks of opening the bottle.
Brief Description
Indication
Open-angle glaucoma, Ocular hypertension
Administration
Shake well before use
If more than 1 ophthalmic drop is administered, the drugs should be administered at least 5 minutes apart
Adult Dose
The recommended dose is one drop in the affected eye(s) 2-3 times daily.
Child Dose
2 years: Instill 1 drop in the affected eye(s) 2-3 times daily.
Contraindication
This eye drops are contraindicated in patients who are hypersensitive to any component of this product.
Mode of Action
Brinzolamide is a carbonic anhydrase inhibitor that decreases secretion of aqueous humor thus reducing intraocular pressure.
Brimonidine is an alpha 2-adrenoceptor agonist which works to reduce aqueous humor production and increase uveoscleral flow.
Precaution
Hepatic and renal impairment; pregnancy. Efficacy has not been established in angle-closure glaucoma. Ensure an interval of at least 10 minutes between admin of different ophthalmic solutions. Patients wearing soft contact lenses should wait for at least 15 min after instilling brimonidine tartrate before inserting soft contact lenses. General Brimonidine ophthalmic solution 0.2% should be used with caution in patients with known hypersensitivity to other alpha-adrenoceptor agonists. Although brimonidine had minimal effect on blood pressure and heart rate of patients in clinical studies, caution should be exercised in treating patients with severe cardiovascular disease. Lactation: Unknown whether distributed in human...
... Show moreSide Effect
>10% (brimonidine) Somnolence in children (50-83%),Xerostomia (10-30%),Ocular hyperemia (10-30%),Burning and stinging (10-30%),Headache (10-30%),Blurring (10-30%),Foreign body sensation (10-30%),Fatigue/drowsiness (10-30%),Conjunctival follicles (10-30%),Ocular allergic reactions (10-30%),Ocular pruritus (10-30%) 1-10% (brinzolamide) Blurred vision (5-10%),Dysgeusia (5-10%),Blepharitis (1-5%),Dermatitis (1-5%),Dry eye (1-5%),Foreign body sensation (1-5%),Headache (1-5%),Hyperemia (1-5%),Ocular discharge (1-5%),Ocular discomfort (1-5%),Ocular keratitis (1-5%),Ocular pain (1-5%),Ocular pruritus (1-5%),Rhinitis (1-5%) 1-10% (brimonidine) Corneal staining/erosion (3-9%),Photophobia (3-9%),Eyelid erythema (3-9%),Ocular ache/pain (3-9%),Ocular dryness (3-9%),Tearing (3-9%),Upper respiratory symptoms (3-9%),Eyelid edema (3-9%),Conjunctival edema (3-9%),Dizziness (3-9%),Blepharitis (3-9%),Ocular (3-9%),Irritation (3-9%),Gastrointestinal symptoms (3-9%),Asthenia (3-9%),Conjunctival blanching (3-9%),Abnormal vision (3-9%) Muscular pain (3-9%),Lid crusting (<3%),Conjunctival hemorrhage (<3%),Abnormal taste (<3%),Insomnia (<3%),Conjunctival discharge (<3%),Depression (<3%),Hypertension (<3%),Anxiety (<3%),Palpitations/arrhythmias (<3%),Nasal dryness (<3%),Syncope...
... Show morePregnancy Category Note
Pregnancy Category: C
Lactation: Unknown whether distributed in human breast milk; do not breast feed
Interaction
Brinzolamide: Concurrent use w/ oral carbonic anhydrase inhibitors may lead to additive systemic effects. Concurrent use w/ high-dose salicylates may lead to toxicity.
Brimonidine Tartrate: Possibility of an additive or potentiating effect with CNS depressants e.g. alcohol, barbiturates, opiates, sedatives or anaesthetics. Caution when used with ?-blockers (ophthalmic and systemic), antihypertensives or cardiac glycosides. TCAs can affect the metabolism and uptake of circulating amines.
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