12-24 Hours
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Synamet 275
Healthcare Pharmaceuticals Ltd.
Generic: Carbidopa + Levodopa
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Synamet 275.
CONSULT YOUR DOCTOR
Synamet 275 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Synamet 275 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Partial to complete suppression of lactation was seen in mothers on the treatment with Synamet 275, but when the treatment was stopped, lactation returned to normal levels.
UNSAFE
Synamet 275 may cause side effects which could affect your ability to drive.
As Synamet 275 may cause dizziness, drowsiness, double vision, which may affect your ability to react which may affect your ability to drive.
SAFE IF PRESCRIBED
Synamet 275 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Synamet 275 may not be needed in these patients. Please consult your doctor.
CAUTION
Synamet 275 should be used with caution in patients with liver disease. Dose adjustment of Synamet 275 may be needed. Please consult your doctor.
Medicine Overview of Synamet 275 25mg+250mg Tablet
Introduction
Synamet 275 is a combination of two medicines used to treat Parkinson’s disease. It is one of the most effective medications to relives symptoms of Parkinson’s disease such as tremor, muscle stiffness and difficulty moving. Synamet 275 can be taken without food but it is better to avoid high protein diet and dairy products while taking this medicine. However, it is advised to take it at the same time each day as this helps to maintain consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor and if you have missed...
... Show moreUses of Synamet 275
- Parkinson's disease
Side effects of Synamet 275
Common
- Nausea
- Vomiting
- Dryness in mouth
- Constipation
- Dizziness
- Sleepiness
- Headache
- Abnormal dreams
- Anxiety
- Insomnia (difficulty in sleeping)
- Abnormality of voluntary movements
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
How to use Synamet 275
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Synamet 275 is to be taken empty stomach.
Avoid Synamet 275 with high protein meals such as cottage cheese, Swiss cheese, protein powder, eggs and milk.
How Synamet 275 works
Synamet 275 is a combination of two medicines: Levodopa and Carbidopa which treats Parkinsonism. Levodopa is a dopamine precursor which gets converted to dopamine, a chemical messenger that controls movement in the brain. Carbidopa is a peripheral decarboxylase inhibitor which prevents breakdown of levodopa allowing it to enter the brain and increase dopamine levels.
Quick Tips
- You have been prescribed Synamet 275 to treat your symptoms of Parkinson's disease.
- It can be taken with or without food or as directed by your doctor.
- Reduce/avoid a high-protein diet (e.g. meat, poultry, and dairy products) while you are taking the medicine as it can reduce the amount of medication absorbed by your body.
- Be cautious while driving or doing anything that requires concentration as Synamet 275 can make you very sleepy.
- When you start the medication, get out of bed slowly, as the medication may cause dizziness, lightheadedness or fainting.
- Do not stop taking the medication without talking to your doctor. It may result in a serious syndrome that causes fever, stiff muscles, unusual body movements, sweating, and confusion.
- Talk to your doctor in case you develop hallucinations or other changes in your behavior.
Brief Description
Indication
Parkinson's disease.
Adult Dose
Parkinson Disease & Parkinson like Disorders
Adult: PO: Immediate release: 25 mg/100 mg q8hr or 10 mg/100 mg PO q6-8hr initially; levodopa may be increased by 100 mg/day every 1-2 days
Carbidopa should be 70-100 mg/day but not to exceed 200 mg/day; levodopa not to exceed 800 mg/day
CR tablet: 50 mg/200 mg PO q12hr initially; may be increased up to 1600 mg/day of levodopa; doses must be given at least 6 hours apart
Hepatic impairment: Safety and efficacy not established; use with caution
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Safety and efficacy not established; use with caution
Contraindication
Lactation, narrow angle glaucoma, melanoma, psychosis, severely decompensated endocrine.
Mode of Action
Levodopa is the metabolic precurosor of dopamine, it crosses the blood-brain barrier and is converted to dopamine in the brain. Carbidopa increases the amount of levodopa that is transported into the CNS by inhibiting the decarboxylation of peripheral levodopa.
Precaution
Heart disease, liver disease, dementia, psychosis, pregnancy, elderly, heart disease. Regular monitoring of renal and hepatic function is reccomended.
Lactation: Drug inhibits lactation; use with caution
Side Effect
Edema,Agitation, anxiety, ataxia, bruxism, confusion, daytime somnolence decreased attention span, dyskinesia, dystonia, euphoria, insomnia, fainting, fatigue, increased trembling of hands, insouciance, malaise, memory loss, nightmares, nervousness, restlessness, trismus, vivid dreams,Alopecia, hot flushes, increased &/or dark perspiration, skin eruptions,Abdominal pain & discomfort, burning feeling in tongue, constipation, diarrhea, dysgeusia, dry mouth, dysphagia, hiccups, meteorism, sialorrhea, nausea, weight loss,Muscular spasms, muscular cramp,Hematuria, dark urine, incontinence, priapism, urine retention,Blurred vision, diplopia, dilated pupil, oculogyric problems.
Potentially Fatal: Severe postural hypotension in elderly.
Pregnancy Category Note
Pregnancy category: C
Lactation: Drug inhibits lactation; use with caution
Interaction
Pyridoxine reverses effects of levodopa. Type-B MAOIs have synergistic effect. Effect reduced by phenothiazines, haloperidol, reserpine, pyridoxine, diazepam, oxazepam, chlordiazepoxide, phenobarbitone. Effects of levodopa enhanced by carbidopa, amantadine, anticholinergics, amphetamine. Effects of sympathomimetic agents enhanced.
Potentially Fatal: Enhances hypotensive effects of bethanidine, bretylium, guanethidine. Hypertensive crises with furazolidone or MAO inhibitors.
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