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Twindopa 125

Tablet-(25mg+100mg)
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Incepta Pharmaceuticals Ltd.

Generic: Carbidopa + Levodopa

10 Tablets (1 Strip)
৳ 72
৳ 80
10% OFF
Alternative Brands For Twindopa 125

Medicine Overview of Twindopa 125mg+100mg Tablet

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Introduction

Twindopa 125 is a combination of two medicines used to treat Parkinson’s disease. It is one of the most effective medications to relives symptoms of Parkinson’s disease such as tremor, muscle stiffness and difficulty moving. Twindopa 125 can be taken without food but it is better to avoid high protein diet and dairy products while taking this medicine. However, it is advised to take it at the same time each day as this helps to maintain consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor and if you have missed a dose, take it as soon as you remember it. You should never skip any doses and try to finish the full course of treatment even if you feel better. Do not stop taking medicine until told by your doctor as it can cause harmful effects. This medicine may cause side effects like nausea, vomiting, dryness in mouth, constipation, and headache. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, so it's better to rise slowly if you have been sitting or lying down. It causes a sudden onset of dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Take caution while taking medicine if you are suffering from liver or kidney disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Uses of Twindopa 125

  • Parkinson's disease

Side effects of Twindopa 125

Common
  • Nausea
  • Vomiting
  • Dryness in mouth
  • Constipation
  • Dizziness
  • Sleepiness
  • Headache
  • Abnormal dreams
  • Anxiety
  • Insomnia (difficulty in sleeping)
  • Abnormality of voluntary movements
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)

How to use Twindopa 125

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Twindopa 125 is to be taken empty stomach. Avoid Twindopa 125 with high protein meals such as cottage cheese, Swiss cheese, protein powder, eggs and milk.

How Twindopa 125 works

Twindopa 125 is a combination of two medicines: Levodopa and Carbidopa which treats Parkinsonism. Levodopa is a dopamine precursor which gets converted to dopamine, a chemical messenger that controls movement in the brain. Carbidopa is a peripheral decarboxylase inhibitor which prevents breakdown of levodopa allowing it to enter the brain and increase dopamine levels.

Quick Tips

  • You have been prescribed Twindopa 125 to treat your symptoms of Parkinson's disease.
  • It can be taken with or without food or as directed by your doctor.
  • Reduce/avoid a high-protein diet (e.g. meat, poultry, and dairy products) while you are taking the medicine as it can reduce the amount of medication absorbed by your body.
  • Be cautious while driving or doing anything that requires concentration as Twindopa 125 can make you very sleepy.
  • When you start the medication, get out of bed slowly, as the medication may cause dizziness, lightheadedness or fainting.
  • Do not stop taking the medication without talking to your doctor. It may result in a serious syndrome that causes fever, stiff muscles, unusual body movements, sweating, and confusion.
  • Talk to your doctor in case you develop hallucinations or other changes in your behavior.

Brief Description

Indication

Parkinson's disease.

Adult Dose

Parkinson Disease & Parkinson like Disorders Adult: PO: Immediate release: 25 mg/100 mg q8hr or 10 mg/100 mg PO q6-8hr initially; levodopa may be increased by 100 mg/day every 1-2 days Carbidopa should be 70-100 mg/day but not to exceed 200 mg/day; levodopa not to exceed 800 mg/day CR tablet: 50 mg/200 mg PO q12hr initially; may be increased up to 1600 mg/day of levodopa; doses must be given at least 6 hours apart Hepatic impairment: Safety and efficacy not established; use with caution

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment: Safety and efficacy not established; use with caution

Contraindication

Lactation, narrow angle glaucoma, melanoma, psychosis, severely decompensated endocrine.

Mode of Action

Levodopa is the metabolic precurosor of dopamine, it crosses the blood-brain barrier and is converted to dopamine in the brain. Carbidopa increases the amount of levodopa that is transported into the CNS by inhibiting the decarboxylation of peripheral levodopa.

Precaution

Heart disease, liver disease, dementia, psychosis, pregnancy, elderly, heart disease. Regular monitoring of renal and hepatic function is reccomended. Lactation: Drug inhibits lactation; use with caution

Side Effect

Edema,Agitation, anxiety, ataxia, bruxism, confusion, daytime somnolence decreased attention span, dyskinesia, dystonia, euphoria, insomnia, fainting, fatigue, increased trembling of hands, insouciance, malaise, memory loss, nightmares, nervousness, restlessness, trismus, vivid dreams,Alopecia, hot flushes, increased &/or dark perspiration, skin eruptions,Abdominal pain & discomfort, burning feeling in tongue, constipation, diarrhea, dysgeusia, dry mouth, dysphagia, hiccups, meteorism, sialorrhea, nausea, weight loss,Muscular spasms, muscular cramp,Hematuria, dark urine, incontinence, priapism, urine retention,Blurred vision, diplopia, dilated pupil, oculogyric problems. Potentially Fatal: Severe postural hypotension in elderly.

Pregnancy Category Note

Pregnancy category: C Lactation: Drug inhibits lactation; use with caution

Interaction

Pyridoxine reverses effects of levodopa. Type-B MAOIs have synergistic effect. Effect reduced by phenothiazines, haloperidol, reserpine, pyridoxine, diazepam, oxazepam, chlordiazepoxide, phenobarbitone. Effects of levodopa enhanced by carbidopa, amantadine, anticholinergics, amphetamine. Effects of sympathomimetic agents enhanced. Potentially Fatal: Enhances hypotensive effects of bethanidine, bretylium, guanethidine. Hypertensive crises with furazolidone or MAO inhibitors.

Buy Twindopa 125 from Arogga

In Bangladesh, you can get the original Twindopa 125. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Twindopa 125 in Bangladesh?

The latest price of Twindopa 125 in Bangladesh is 72৳. You can buy Twindopa 125 at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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UNSAFE
It is unsafe to consume alcohol with Twindopa 125.
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CONSULT YOUR DOCTOR
Twindopa 125 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
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SAFE IF PRESCRIBED
Twindopa 125 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. Partial to complete suppression of lactation was seen in mothers on the treatment with Twindopa 125, but when the treatment was stopped, lactation returned to normal levels.
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UNSAFE
Twindopa 125 may cause side effects which could affect your ability to drive. As Twindopa 125 may cause dizziness, drowsiness, double vision, which may affect your ability to react which may affect your ability to drive.
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SAFE IF PRESCRIBED
Twindopa 125 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Twindopa 125 may not be needed in these patients. Please consult your doctor.
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CAUTION
Twindopa 125 should be used with caution in patients with liver disease. Dose adjustment of Twindopa 125 may be needed. Please consult your doctor.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.