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Lecaren 100
General Pharmaceuticals Ltd.
Generic: Carbidopa + Entacapone + Levodopa
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Lecaren 100.
CONSULT YOUR DOCTOR
Lecaren 100 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Lecaren 100 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Lecaren 100 may cause side effects which could affect your ability to drive.
Caution is advised when driving or operating machinery.
SAFE IF PRESCRIBED
Lecaren 100 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Lecaren 100 may not be needed in these patients. Please consult your doctor.
CAUTION
Lecaren 100 should be used with caution in patients with liver disease. Dose adjustment of Lecaren 100 may be needed. Please consult your doctor.
Medicine Overview of Lecaren 100 25mg+200mg+100mg Tablet
Introduction
Lecaren 100 is a prescription medicine used in the treatment of Parkinson's disease. This medicine helps to reduce excessive shaking by slowing down the body movements. It works by increasing the amount of chemical messenger that is needed to control abnormal movements. Lecaren 100 is taken with or without food, but better to avoid high protein meal and dairy products. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor and if...
... Show moreUses of Lecaren 100
- Parkinson's disease
Side effects of Lecaren 100
Common
- Nausea
- Vomiting
- Constipation
- Urine discoloration
- Headache
- Dryness in mouth
- Insomnia (difficulty in sleeping)
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Anxiety
- Dizziness
- Abnormality of voluntary movements
- Abnormal dreams
How to use Lecaren 100
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lecaren 100 may be taken with or without food, but it is better to take it at a fixed time.
Avoid Lecaren 100 with high protein meals such as cottage cheese, Swiss cheese, protein powder, eggs and milk.
How Lecaren 100 works
Lecaren 100 is a combination of three medicines: Levodopa, Carbidopa and Entacapone which treat Parkinsonism. Levodopa is a Carbidopa precursor which gets converted to dopamine, a chemical messenger that controls movement in the brain. Carbidopa is a peripheral decarboxylase inhibitor which prevents the breakdown of Levodopa allowing it to enter the brain and increase dopamine levels. Entacapone is COMT inhibitor which causes higher and more sustained levels of levodopa in blood, leading to greater relief from the symptoms of Parkinson’s disease.
Quick Tips
- You have been prescribed Lecaren 100 to treat your symptoms of parkinson's disease.
- Avoid a high-protein diet (eg.meat, poultry, and dairy products) while you are taking this medicine as that can reduce the amount of medication absorbed by your body.
- It may cause dizziness or sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Do not stop taking the medication suddenly without talking to your doctor. It may result in a serious syndrome that causes fever, stiff muscles, unusual body movements, sweating and confusion.
- Talk to your doctor in case you develop hallucinations or notice other changes in your behavior.
Brief Description
Indication
Parkinson's disease and 'end of dose' motor fluctuations
Administration
May be taken with or without food. Keep a consistent diet. A change in diet to foods high in protein may delay levodopa absorption & reduce amount taken up in circulation. Excessive acidity also delays stomach emptying & thus delays levodopa absorption. Fe salts (eg in multivit prep) may also reduce amount of levodopa available to the body. Swallow whole.
Adult Dose
Parkinson's disease
Adult: PO: Each tab contains levodopa and carbidopa in a ratio of 4:1 and entacapone 200 mg: Initial: 1 tab/day. Titrate dose according to patient's response. Recommended to take only 1 tab per dose administration. Max: 8 tabs/day.
Hepatic impairment: Severe: Contraindicated.
Child Dose
Safety & efficacy not established
Contraindication
Hypersensitivity. Narrow angle glaucoma. Should not be used in patients with suspicious, undiagnosed skin lesions or a history ot melanoma.
Mode of Action
Levodopa is the metabolic precurosor of dopamine, it crosses the blood-brain barrier and is converted to dopamine in the brain. Carbidopa increases the amount of levodopa that is transported into the CNS by inhibiting the decarboxylation of peripheral levodopa. Entacapone is a selective inhibitor of catechol-o-methyltransferase. Given concurrently, entacapone results in greater and more substained plasma levels of levodopa, leading to greater control of parkinsonism symptoms.
Precaution
Periodic monitoring of hepatic, renal, haematopoietic and CV functions in patients on prolonged therapy. Monitor for changes in IOP in patients with chronic wide-angle glaucoma. Caution when used in patients with biliary obstruction. Caution when interpreting plasma and urine levels of catecholamines and their metabolites. Withdrawal should be gradual.
Lactation: not known if excreted in breast milk; use caution
Side Effect
>10% Entacapone Dyskinesia (25%),Nausea (14%),Diarrhea (10%),Hyperkinesia (10%),Urine discoloration (10%) 1-10% Entacapone Hypokinesia (9%), dizziness (8%), Fatigue (6%), hallucinations (1-4%), anxiety (2%), somnolence (2%), asthenia (2%), agitation (1%),Increased sweating (2%),Purpura (2%),Abdominal pain (8%), constipation (6%), vomiting (4%), dry mouth (3%), dyspepsia (2%), flatulence (2%), taste perversion (1%), gastritis (1%),Back pain (4%),Dyspnea (3%),Bacterial infection (1%) Frequency Not Defined Levodopa/Carbodopa Edema,Agitation, anxiety, ataxia, bruxism, confusion, daytime somnolence decreased attention span, dyskinesia, dystonia, euphoria, insomnia, fainting, fatigue, increased trembling of hands, insouciance, malaise, memory loss, nightmares, nervousness, restlessness, trismus, vivid dreams,Alopecia, hot flushes, increased &/or dark perspiration, skin eruptions,Abdominal pain & discomfort, burning feeling...
... Show morePregnancy Category Note
Pregnancy Category: C
Lactation: not known if excreted in breast milk; use caution
Interaction
Increased risk of postural hypotension when used concurrently with hypotensive drugs. Severe orthostatic hypotension may result from concurrent usage with MAOIs. Dopamine D2 receptor antagonists, phenytoin or papaverine may reduce the efficacy of levodopa. Iron salts may reduce the bioavailability. Concurrent usage with drugs that interfere with biliary excretion may lead to increased plasma levels of entacapone. May depress prolactin secretion and increase growth hormone levels.
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