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Medicine Overview of Clinorel 200mg Tablet
বাংলা
English
Indication
Rheumatoid arthritis, Osteoarthritis, Acute gouty arthritis, Ankylosing spondylitis, Acute painful shoulder
Administration
Should be taken with food.
Adult Dose
Oral
Ankylosing spondylitis; Osteoarthritis; Rheumatoid arthritis
Adult: For symptomatic treatment: 150 mg bid; may adjust subsequent doses based on response. Max: 400 mg/day.
Acute painful shoulder
Adult: For symptomatic treatment: 200 mg bid; may reduce dose after satisfactory response achieved. Max: 400 mg/day. Treatment duration: 7-14 days is usually adequate.
Acute gouty arthritis
Adult: For symptomatic treatment: 200 mg bid; may reduce dose after satisfactory response achieved. Max: 400 mg/day. Treatment duration: 7 days is usually adequate.
Hepatic impairment: Acute and chronic hepatic disease: May need dosage reduction.
Child Dose
Safety & efficacy not established
Renal Dose
Renal impairment: May need dosage reduction. Not recommended in severe renal impairment.
Contraindication
Hypersensitivity. Pregnancy (3rd trimester), treatment of peri-operative pain in CABG surgery .
Mode of Action
Sulindac is a prodrug which undergoes reversible reduction to its active sulfide metabolites. It inhibits prostaglandin synthesis by decreasing cyclooxygenase activity.
Precaution
Use at lowest effective dose for shortest duration possible. NSAIDs may increase risk of severe cardiovascular (CV) thrombotic events, myocardial infarction, and stroke. Risk may be increased with duration of use or pre-existing CV disease or risk factors. Treatment has been associated with new onset hypertension or worsening of pre-existing hypertension. May cause fluid retention and oedema; caution in heart failure. NSAIDs can cause serious GI adverse events including GI inflammation, ulceration, bleeding, and perforation. Caution in patients with history of GI disease; concomitant use of aspirin, anticoagulants and/or oral corticosteroids; smoking, use of alcohol, elderly or debilitated patients. Anaemia...
... Show moreSide Effect
1-10%
GI pain (10%),Constipation (3-9%),Diarrhea (3-9%),Dizziness (3-9%),Dyspepsia (3-9%),Headache (3-9%),Nausea (3-9%),Rash (3-9%),Abdominal cramps (1-3%),Anorexia (1-3%),Edema (1-3%),Nervousness (1-3%),Pruritus (1-3%),Tinnitus (1-3%),Vomiting (1-3%)
<1%
Hypersensitivity reactions,Thrombocytopenia,Ecchymosis,Purpura,Leukopenia,Agranulocytosis,Neutropenia,Bone marrow depression,CHF (<1%),Hematuria (<1%),Renal impairment (including renal failure),Interstitial nephritis,Nephrotic syndrome
Potentially Fatal: Anaphylaxis reactions; cross-sensitivity reactions in patients with known aspirin triad reactions; Steven-Johnson Syndrome and toxic epidermal necrolysis.
Pregnancy Category Note
Pregnancy Category: C; D in 3rd trimester.
Interaction
Concomittent use with dimethyl sulfoxide may result in peripheral neuropathy. Increased nephrotoxicity with ciclosporin; increased risk of methotrexate toxicity; increased risk of bleeding with other NSAIDs, warfarin and thrombolytic agents. Antagonises effect of antihypertensives. Unpredictable interactions with lithium.
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