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Clobex
Beximco Pharmaceuticals Ltd.
Generic: Cloxacillin
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Clobex does not cause any harmful side effects.
SAFE IF PRESCRIBED
Clobex is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Clobex is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Clobex does not usually affect your ability to drive.
CAUTION
Clobex should be used with caution in patients with kidney disease. Dose adjustment of Clobex may be needed. Please consult your doctor.
Regular monitoring of kidney function tests is advised while taking this medicine.
CAUTION
Clobex should be used with caution in patients with liver disease. Dose adjustment of Clobex may be needed. Please consult your doctor.
Regular monitoring of liver function tests is advised while taking this medicine.
Medicine Overview of Clobex 500mg Capsule
Introduction
Clobex is an antibiotic used to treat various bacterial infections. It is effective in infections of the throat, ear, nasal sinuses, respiratory tract, and skin and soft tissue. It mainly fights and stops the growth of the gram-positive type of bacteria. Clobex should be taken on an empty stomach. For best results, it should be used regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. Do not skip any doses and finish the full course of treatment even if you...
... Show moreUses of Clobex
- Bacterial infections
Side effects of Clobex
Common
- Rash
- Vomiting
- Allergic reaction
- Nausea
- Diarrhea
How to use Clobex
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clobex is to be taken empty stomach.
How Clobex works
Clobex is an antibiotic. It kills bacteria by preventing them from forming their own protective covering (cell wall) which is needed for them to survive.
Quick Tips
- You have been prescribed Myoclox CV 625mg Tablet for the treatment of bacterial infections.
- Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
- Take it with food and plenty of fluids to avoid an upset stomach.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
- Inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking this medicine.
Brief Description
Indication
Staphylococcal infections resistant to benzylpenicillin
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Reconstitution: IM: The contents of each vial should be dissolved in 1.5 mL of water for inj.
IV: 500 mg to be dissolved in 10-20 mL of water for inj, added to suitable IV fluids if given for i
Adult Dose
Oral
Adult: 250-500 mg 4 times/day.
Parenteral
Adult: 1-2 g 6 hrly. For more severe infections (e.g. meningitis, endocarditis), 2 g 4 hrly.
Child Dose
Oral
Child: 50-100 mg/kg in divided doses every 6 hr.
Contraindication
Hypersensitivity to cloxacillin and other penicillins.
Mode of Action
Cloxacillin inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
Precaution
Patient w/ allergies esp β-lactam allergy, asthma, history of seizure disorder. Renal impairment. Pregnancy and lactation. Monitoring Parameters Observe for signs and symptoms of anaphylaxis during 1st dose. Monitor CBC w/ differential (prior to initiating therapy and wkly thereafter), periodic BUN, creatinine, hepatic function.
Side Effect
Hypotension, confusion, fever, lethargy, seizure, pruritus, rash, urticaria, abdominal pain, black or hairy tongue, diarrhoea, flatulence, nausea, oral candidiasis, pseudomembranous colitis, stomatitis, vomiting, agranulocytosis, bone marrow depression, eosinophilia, granulocytopenia, haemolytic anaemia, leucopenia, neutropenia, thrombocytopenia, increased alkaline phosphatase, ALT and AST, hepatotoxicity, thrombophlebitis, arthralgia, myalgia, myoclonus, hematuria, interstitial nephritis, proteinuria, renal insufficiency, renal tubular damage, bronchospasm, laryngeal oedema, laryngospasm, sneezing, wheezing, angioedema, allergic reaction, serum sickness-like reaction.
Potentially Fatal: Anaphylaxis.
Interaction
May diminish the effect of BCG and typhoid vaccine. May increase risk of methotrexate toxicity. May diminish the therapeutic effect of Na picosulfate. May decrease serum concentrations of mycophenolate. May prolong bleeding time w/ anticoagulants. Increased serum concentrations w/ probenecid. Tetracycline may antagonise the bactericidal effect of cloxacillin.
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