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Pimponil
Kumudini Pharma Ltd.
Generic: Clindamycin Phosphate 1.2% + Tretinoin 0.025% Topical
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
Pimponil may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Pimponil is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Medicine Overview of Pimponil 15gm Gel
Introduction
Pimponil is a combination of two medicines, used to treat acne, which appears as spots or pimples on your face, chest or back. This medicine works by attacking the germs that cause them and rejuvenates sun damaged skin. Pimponil is only meant for external use and should be used as advised by your doctor. You should normally wash and dry the affected area before applying a thin layer of the medicine. It should not be applied to broken or damaged skin. Avoid contact with your eyes, nose or mouth. Rinse it off with water if you accidentally get it in...
... Show moreUses of Pimponil
- Acne
Side effects of Pimponil
Common
- Application site reactions (burning, irritation, itching and redness)
- Dryness
- Skin peeling
- Dermatitis
How to use Pimponil
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.
How Pimponil works
Pimponil is a combination of two medicines: Clindamycin and Tretinoin, which treats pimples (acne). Clindamycin is an antibiotic which works by penetrating into the skin and killing acne-causing bacteria. Tretinoin is a form of vitamin A which reduces oil production in the skin, replenishes the skin and helps keep your pores open.
Quick Tips
- Retino AC Gel should be Applied as a thin layer onto clean, dry, unbroken skin affected by acne.
- Clean the area to be treated with water and a non-medicated soap, and let it dry for 20-30 minutes before applying the medicine.
- It may cause minor burning, stinging, or irritation when applied. Inform your doctor if this does not go away.
- Avoid contact with your eyes, nose or mouth. Rinse it off with water if you accidentally get the cream in these areas.
- Avoid exposure to sunlight while using Retino AC Gel as it increases the sensitivity of your skin. Use protective measures such as sun-cream or protective clothing.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Acne vulgaris
Administration
At first wash the face or affected area gently with warm water or soap.
When the skin is completely dried (about 30 minutes later) apply a pea-size amount of gel to your fingertip and spread it over your face.
Adult Dose
Acne Vulgaris
Topical
Apply a pea-size amount of gel once daily preferably at bed time.
Treatment should be continued for 12 weeks.
Child Dose
12 years: Apply a pea-size amount of gel once daily preferably at bed time.
Contraindication
Contraindicated in patients with hypersensitivity to clindamycin or tretinoin or any of the ingredients of these medicine.
Mode of Action
Clindamycin: Antibacterial agent that binds to the 50S ribosomal subunits of susceptible bacteria and prevents elongation of peptide chains by interfering with peptidyl transfer, thereby suppressing protein synthesis; reduces surface fatty acids on skin; exact mechanism of action in treating acne unknown
Tretinoin: Exact mechanism unknown; appears to cohesiveness of follicular epithelial cells with decrease microcomedo formation; also increases turnover of follicular cells to cause extrusion of comedones
Precaution
Clindacin plus gel is not for oral, ophthalmic, or Intravaginal use.
Avoid exposure to sunlight and sunlamps. Wear sunscreen daily.
Lactation: excretion in milk unknown; use with caution
Side Effect
>10%
Erythema (21-35%),Scaling (13-19%),Itching (15-17%)
1-10%
Dryness (6%),Irritation (5%),Exfoliation (5%),Erythema (4%),Pruritus (2%),Stinging (2%),Burning (2%),Sunburn (1%),Dermatitis (1%)
Pregnancy Category Note
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
Interaction
Clindamycin: May enhance the action of neuromuscular blocking agents (e.g. atracurium). May antagonise the effects of parasympathomimetics. May competitively inhibit the effects of macrolides, ketolides, streptogramins, linezolid and chloramphenicol. Increased coagulation tests (prothrombin time/INR) and/or bleeding w/ vit K antagonists (e.g. warfarin, acenocoumarol, fluindione).
Tretinoin: Enhances percutaneous absorption of minoxidil. Increased risk of fatal thrombotic complications with antifibrinolytic. Increased tretinoin concentrations with azole antifungals. Enhances peeling action of sulphur, resorcinol, benzoyl peroxide, salicylic acid. Increased photosensitivity with photosensitising medications eg, thiazides, tetracyclines, fluoroquinolones, phenothiazines and sulfonamides.
Potentially Fatal: Increased risk of intracranial pressure with tetracyclines.
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