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Clozosone
Unimed Unihealth Pharmaceuticals Ltd.
Generic: Betamethasone 0.1% + Clotrimazole 1% Topical
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
Clozosone may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Clozosone is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Medicine Overview of Clozosone 0.1%+1% Cream
Introduction
Clozosone is a combination medicine. It is used to treat various types of skin infections usually the fungal type of skin infections. It minimizes symptoms of inflammation such as redness, swelling, and itching. It also acts against the infection-causing microorganisms. Clozosone is only meant for external use and should be used as advised by your doctor. A thin layer of the medicine should be applied only to the affected areas of the skin with clean and dry hands. If it gets into your eyes, nose, mouth, or vagina rinse with water. It may take several days to weeks for your...
... Show moreUses of Clozosone
- Skin infections
Side effects of Clozosone
Common
- Application site reactions (burning, irritation, itching and redness)
- Thinning of skin
- Skin peeling
How to use Clozosone
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.
How Clozosone works
Clozosone is a combination of two medicines: Betamethasone and Clotrimazole which treat skin infections. Betamethasone is a steroid which blocks the production of certain chemical messengers (prostaglandins) that make the skin red, swollen and itchy. Clotrimazole is an antifungal which stops the growth of fungi on the skin by preventing them from forming their own protective covering.
Quick Tips
- You have been prescribed Clozosone for the treatment of fungal skin infections.
- It is for use on skin only. Do not use it in your eyes, mouth, or vagina. Rinse with cold water if you accidentally get it in these areas.
- Do not cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects.
- If you think the area of skin you are treating has become more irritated and infected, you should stop using Clozosone and consult your doctor.
- Do not use this medicine more often or for longer than advised by your doctor. Inform your doctor if the treated skin area does not improve after 2 weeks of treatment.
Brief Description
Indication
Tinea pedis, tinea cruris, tinea corporis, ringworm, athlete's foot, jock itch.
Adult Dose
Tinea Pedis, Tinea Cruris, & Tinea Corporis
Apply to infected area q12hr for 2 weeks for tinea cruris and tinea corporis; 4 weeks for tinea pedis
Allergic or Inflammatory Diseases
Apply to affected area in the morning and evening
Child Dose
<17 years: Safety and efficacy not established
Contraindication
Patients who are sensitive to clotrimazole, betamethasone dipropionate, other corticosteroids or imidazoles, or to any ingredient in these preparations.
Mode of Action
Betamethasone is a corticosteroid with mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein synthesis, depressing the migration of polymorphonuclear leukocytes and fibroblasts, and reversing capillary permeability and lysosomal stabilisation.
Clotrimazole is an antifungal agent that binds to phospholipids in the fungal cell membrane. It causes loss of essential intracellular components by altering cell wall permeability.
Precaution
Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment. Manifestations of Cushing's syndrome, hyperglycemia, and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids while on treatment. Conditions which augment systemic absorption include use over large surface areas, prolonged use, and use under occlusive dressings. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent corticosteroid. Pediatric patients may be more susceptible to systemic toxicity...
... Show moreSide Effect
1-10%
Dry skin (2%),Paresthesia (2%),Local burning (2%)
2 wk)
Pregnancy Category Note
Pregnancy There are no available data on topical betamethasone dipropionate or clotrimazole use in pregnant women to identify drug associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes; observational studies suggest an increased risk of low birthweight infants with use of potent or very potent topical corticosteroid during pregnancy Advise pregnant women that therapy may increase risk of having a low birthweight infant and to use drug on the smallest area of skin and for shortest duration possible Animal data In an animal reproduction study, betamethasone dipropionate caused malformations (ie, umbilical hernias, cephalocele, and cleft palate)...
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